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Conti_GE_2025
conti_ge_2025_RNAseq
Commits
f9b173e7
Commit
f9b173e7
authored
May 05, 2025
by
Stefano Beretta
Browse files
Added GSEA results.
parent
0fb7de9c
Changes
24
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paired_stranded24h/GE_24h-RNP_NEG_24h-gsea-h.all.v7.2.symbols.txt
0 → 100755
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f9b173e7
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paired_stranded24h/GE_24h-RNP_NEG_24h-gsea-sasp.txt
0 → 100755
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f9b173e7
ID Description setSize enrichmentScore NES pvalue p.adjust qvalues rank leading_edge core_enrichment
CLASSICAL_SASP CLASSICAL_SASP 34 0.612796711526193 1.54493831994222 0.0145713317519485 0.029142663503897 0.0153382439494195 2579 tags=56%, list=15%, signal=47% KITLG/IFNB1/CCL2/CCL20/CXCL1/BGN/EFEMP1/FGF2/SERPINE1/CXCL8/EGF/COL1A1/GDNF/FN1/MMP9/CSF1/THBS1/FGF7/MMP2
SASP_SCHLEICH SASP_SCHLEICH 72 0.376571539180343 1.07869973389838 0.321864594894562 0.321864594894562 0.169402418365559 2104 tags=35%, list=13%, signal=30% KITLG/CSF2/CCL2/CCL20/CXCL1/MMP10/FGF2/SERPINE1/CCL1/EGF/FAS/MIF/SERPINB2/CXCR2/GEM/NGF/IGFBP3/ITPKA/CPE/IGFBP4/FN1/BHLHE40/AREG/MMP14/ICAM1
paired_stranded24h/GE_24h-RNP_NEG_24h-gsea-senescence_signatures.txt
0 → 100755
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f9b173e7
ID Description setSize enrichmentScore NES pvalue p.adjust qvalues rank leading_edge core_enrichment
SenMayo SenMayo 105 0.494062558817424 1.49098181229325 0.00622761949244901 0.0245983935742972 0.0147960262101036 2579 tags=40%, list=15%, signal=34% IL32/GDF15/MMP1/KITLG/EDN1/CSF2/PGF/VGF/CCL2/CCL20/CST4/ANGPTL4/CXCL1/MMP10/CCL26/FGF2/CCL1/CXCL8/EGF/FAS/MIF/TNFRSF10C/CCL3/CXCR2/CXCL16/GEM/CXCL3/IGFBP3/SPP1/ITPKA/INHA/MMP9/IL10/AREG/MMP14/ICAM1/CSF1/CCL5/SEMA3F/FGF7/PTGES/MMP2
Purcell Purcell 46 0.607478753460442 1.61417952061729 0.0070281124497992 0.0245983935742972 0.0147960262101036 3750 tags=48%, list=22%, signal=37% CCDC80/IL32/COL17A1/BATF2/CLDN1/IDO1/ATF3/CD163L1/IFI30/ICAM1/IFI27/CD82/CYP1A1/PLAU/HERC5/C3/TNFAIP6/OASL/IL1A/CTSS/ISG20/LGALS9
FRIDMAN_SENESCENCE_UP FRIDMAN_SENESCENCE_UP 72 0.508109527176229 1.45835158515664 0.0221432034911912 0.0516674748127795 0.031078180338514 3183 tags=42%, list=19%, signal=34% MMP1/CDKN1A/MDM2/CXCL14/TFAP2A/SERPINE1/SERPINB2/TGFB1I1/IGFBP3/IGFBP4/RRAS/RHOB/FN1/ISG15/IRF7/FILIP1L/CCN2/GSN/OPTN/RABGGTA/THBS1/CCND1/COL1A2/CDKN1C/S100A11/IGFBP2/CD44/SMPD1/VIM/CDKN2D
Casella Casella 49 0.442870332400748 1.19344447551846 0.202120609675282 0.353711066931743 0.212758536500296 3190 tags=29%, list=19%, signal=23% RND3/CLSTN2/CLDN1/DIO2/TNFRSF10C/JCAD/SLCO2B1/SRPX2/FILIP1L/LRP10/KIAA1671/PDLIM1/TMEM30A/TAP1
Sencan Sencan 30 0.465591747853587 1.14761909975994 0.269982847341338 0.377975986277873 0.227353976708495 1076 tags=30%, list=6%, signal=28% MMP1/TAC3/CSF2/EBI3/MMP10/FOLR3/SBSN/CCL3/SERPINB2
Pribluda_SENESCENCE_INFLAMMATORY_GENES Pribluda_SENESCENCE_INFLAMMATORY_GENES 92 0.348227137681198 1.03141315716905 0.40684168655529 0.474648634314505 0.285502937933537 2104 tags=25%, list=13%, signal=22% CDKN1A/CSF2/CCL20/CXCL1/TNFRSF10B/SERPINE1/CPA2/FAS/CD14/HIF3A/MIF/CCL3/FAIM2/GEM/CXCL3/OLR1/IGFBP3/ITPKA/CPE/IGFBP4/BHLHE40/CD276/ICAM1
Hernandez Hernandez 54 0.304873526413206 0.834987412953941 0.755496776326666 0.755496776326666 0.454434151173934 2924 tags=19%, list=18%, signal=15% PDLIM4/PLK3/P4HA2/GDNF/DGKA/SLC16A3/CCND1/B4GALT7/GBE1/TOLLIP
paired_stranded24h/GE_ANAK_24h-GE_24h-gsea-h.all.v7.2.symbols.txt
0 → 100755
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f9b173e7
ID Description setSize enrichmentScore NES pvalue p.adjust qvalue rank leading_edge core_enrichment
HALLMARK_XENOBIOTIC_METABOLISM HALLMARK_XENOBIOTIC_METABOLISM 183 0.459805600916652 1.27707268858001 0.0385852090032154 1 1 1697 tags=14%, list=10%, signal=13% PDK4/CYP17A1/DDC/HSD17B2/GSTT2/CYP1A1/ALDH3A1/TTPA/CYP2C18/ITIH1/HGFAC/UPB1/HNF4A/PTGDS/IGF1/ANGPTL3/RAP1GAP/CYP27A1/FMO1/MPP2/GCKR/PC/LCAT/DDT/ATOH8/IL1R1
HALLMARK_PI3K_AKT_MTOR_SIGNALING HALLMARK_PI3K_AKT_MTOR_SIGNALING 103 -0.478223065234319 -1.26338005815696 0.075744859420898 1 1 1392 tags=11%, list=8%, signal=10% TBK1/CSNK2B/NCK1/MAPK10/CAMK4/SFN/NGF/FASLG/PRKAA2/PITX2/FGF22
HALLMARK_MYOGENESIS HALLMARK_MYOGENESIS 180 -0.419438611355658 -1.18358906600833 0.0944115156646909 1 1 1720 tags=19%, list=10%, signal=17% LARGE1/MYL4/REEP1/DTNA/AK1/SSPN/PYGM/NCAM1/DAPK2/KLF5/CDH13/NAV2/GJA5/CASQ1/ACTN2/CACNA1H/SLC6A8/MYL3/IGFBP3/SH3BGR/EFS/FXYD1/HRC/GPX3/TNNI1/SLN/MYH8/PPP1R3C/HSPB8/CKMT2/CHRNG/FGF2/KCNH1/COX7A1
HALLMARK_BILE_ACID_METABOLISM HALLMARK_BILE_ACID_METABOLISM 100 0.427940922358138 1.11169283830078 0.236021300874857 1 1 2801 tags=24%, list=17%, signal=20% ABCG4/CYP8B1/CYP39A1/SULT2B1/ABCA4/NR3C2/CYP27A1/ABCA6/HSD17B6/RBP1/APOA1/SLC22A18/ABCA1/CYP7B1/HSD3B7/EPHX2/LIPE/MLYCD/BCAR3/ABCA2/FDXR/PEX11G/NUDT12/GNMT
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION 190 -0.386661749679486 -1.09720275532243 0.215264600463841 1 1 2067 tags=19%, list=12%, signal=17% CRLF1/COL1A2/GEM/MAGEE1/SPP1/ITGA2/PDLIM4/RHOB/PFN2/TGM2/MGP/MATN2/BGN/TFPI2/CALD1/COL16A1/CCN2/SERPINE1/OXTR/APLP1/SLC6A8/LAMC2/IGFBP3/COL5A3/DCN/TNC/CCN1/FOXC2/COMP/BDNF/COL12A1/THBS2/SLIT3/FGF2/CADM1/MSX1
HALLMARK_UV_RESPONSE_DN HALLMARK_UV_RESPONSE_DN 141 0.382101393234356 1.03407994544629 0.357264633453306 1 1 1904 tags=13%, list=11%, signal=12% AMPH/PTPN21/IGFBP5/GJA1/HAS2/EFEMP1/IRS1/CAV1/COL1A1/MET/COL3A1/BMPR1A/F3/SLC22A18/NRP1/TJP1/CACNA1A/LPAR1/SCN8A
HALLMARK_KRAS_SIGNALING_DN HALLMARK_KRAS_SIGNALING_DN 162 0.372569266779811 1.02250332040682 0.386161137440758 1 1 1630 tags=22%, list=10%, signal=20% KCNE2/KRT13/ABCG4/CYP39A1/IL5/SLC6A3/OXT/EDN2/SCGB1A1/SHOX2/GDNF/TG/RYR2/TCF7L1/EDN1/KRT5/HTR1B/NOS1/P2RY4/WNT16/KCNN1/LYPD3/SNCB/MYO15A/UPK3B/VPREB1/CALCB/MYH7/ABCB11/TCL1A/GP1BA/ZC2HC1C/PDCD1/ARPP21/TAS2R4
HALLMARK_COMPLEMENT HALLMARK_COMPLEMENT 198 0.364777205826473 1.02063569945842 0.389836935912021 1 1 2142 tags=14%, list=13%, signal=12% COL4A2/ITIH1/C4BPB/HNF4A/MMP8/MT3/F2/CASP5/ANG/ADRA2B/KLKB1/C1QC/C3/LTF/PCSK9/GP1BA/F3/DGKG/PRSS36/F7/SCG3/LGALS3/DOCK9/CP/GNGT2/RASGRP1/CPM
HALLMARK_APICAL_JUNCTION HALLMARK_APICAL_JUNCTION 190 0.365181088662444 1.01802587750112 0.390758699372504 1 1 1773 tags=13%, list=11%, signal=11% CDH8/NFASC/CLDN19/CLDN5/ACTG2/PCDH1/DSC1/ACTN3/NRTN/GRB7/ACTA1/CLDN4/WNK4/MADCAM1/CRB3/CDH6/CADM2/IRS1/MMP9/CDH1/SDC3/IKBKG/TRAF1/TJP1
HALLMARK_ESTROGEN_RESPONSE_EARLY HALLMARK_ESTROGEN_RESPONSE_EARLY 195 0.357273813347631 0.998034817158959 0.442607373622197 1 1 2350 tags=21%, list=14%, signal=18% MLPH/RHOD/KRT13/TMPRSS3/SYBU/SULT2B1/FRK/SYT12/CA12/GJA1/KLK10/CXCL12/IL17RB/MSMB/INHBB/TUBB2B/TPBG/GREB1/ANXA9/RET/SLC7A2/TPD52L1/MYBL1/PRSS23/WWC1/OLFML3/ADCY9/BCL11B/SEMA3B/SCNN1A/TBC1D30/AREG/ABAT/P2RY2/KRT15/MINDY1/RASGRP1/OPN3/STC2/ZNF185/KAZN
HALLMARK_PANCREAS_BETA_CELLS HALLMARK_PANCREAS_BETA_CELLS 28 -0.466035798329655 -0.99679942268301 0.468370080362662 1 1 1242 tags=21%, list=7%, signal=20% PKLR/SCGN/NKX6-1/CHGA/INSM1/ABCC8
HALLMARK_SPERMATOGENESIS HALLMARK_SPERMATOGENESIS 116 0.376341331450745 0.99396520851578 0.45164960182025 1 1 1941 tags=17%, list=12%, signal=15% CFTR/HBZ/LDHC/TULP2/ACRV1/TSSK2/GSG1/CRISP2/NOS1/SCG5/PACRG/IL13RA2/PCSK4/PCSK1N/ZC2HC1C/CHRM4/SCG3/OAZ3/CNIH2/NPHP1
HALLMARK_TGF_BETA_SIGNALING HALLMARK_TGF_BETA_SIGNALING 54 0.4190162914214 0.993742304734135 0.458220502901354 1 1 3420 tags=22%, list=20%, signal=18% BMP2/LEFTY2/CDH1/BMPR1A/TJP1/NOG/BCAR3/ACVR1/TGFB1/SMAD7/NCOR2/JUNB
HALLMARK_WNT_BETA_CATENIN_SIGNALING HALLMARK_WNT_BETA_CATENIN_SIGNALING 41 0.433879088139048 0.984548466750106 0.479033816425121 1 1 2062 tags=17%, list=12%, signal=15% DKK4/WNT6/HEY1/HEY2/TCF7/PTCH1/JAG2
HALLMARK_ESTROGEN_RESPONSE_LATE HALLMARK_ESTROGEN_RESPONSE_LATE 188 -0.346914523520234 -0.983667678907933 0.486480777355302 1 1 1720 tags=13%, list=10%, signal=12% LARGE1/MYOF/MAPK13/EMP2/CHST8/PLAC1/DHRS2/TFPI2/PLAAT3/SCUBE2/SFN/FOXC1/TRIM29/HR/CYP4F11/LAMC2/CCN5/PKP3/AGR2/MAPT/GPER1/CXCL14/SOX3/HSPB8/PTGES
HALLMARK_KRAS_SIGNALING_UP HALLMARK_KRAS_SIGNALING_UP 188 -0.346179331024572 -0.981583058499365 0.492817912970004 1 1 1332 tags=15%, list=8%, signal=14% GABRA3/SPP1/SNAP25/ITGA2/PPBP/PTGS2/SPON1/TMEM158/RBP4/ALDH1A2/CCL20/MPZL2/NAP1L2/EPHB2/WNT7A/SNAP91/CFB/NGF/IGFBP3/MMP10/PDCD1LG2/ITGBL1/H2BC3/GFPT2/PIGR/TMEM100/BTC/ANO1/CXCL10
HALLMARK_CHOLESTEROL_HOMEOSTASIS HALLMARK_CHOLESTEROL_HOMEOSTASIS 72 0.392442360458316 0.973123520261416 0.493731918997107 1 1 1777 tags=10%, list=11%, signal=9% MAL2/ERRFI1/GPX8/GLDC/CYP51A1/SEMA3B/LGALS3
HALLMARK_NOTCH_SIGNALING HALLMARK_NOTCH_SIGNALING 31 -0.435228322908106 -0.949198867002775 0.541263634492694 1 1 3554 tags=32%, list=21%, signal=25% FZD7/FZD5/ST3GAL6/TCF7L2/JAG1/PSEN2/HES1/NOTCH3/FZD1/HEYL
HALLMARK_COAGULATION HALLMARK_COAGULATION 127 -0.35052235511006 -0.947961766212196 0.578780177890724 1 1 1433 tags=14%, list=9%, signal=13% DCT/TFPI2/PDGFB/MMP7/SERPINE1/THBD/CPB2/PROC/MASP2/CFB/F9/F11/MMP10/RGN/COMP/CTSE/F2RL2/OLR1
HALLMARK_MYC_TARGETS_V1 HALLMARK_MYC_TARGETS_V1 199 -0.326922403610754 -0.932093848742393 0.662869198312236 1 1 6871 tags=56%, list=41%, signal=33% CCT2/NME1/HDDC2/G3BP1/CDC20/SSBP1/HSP90AB1/RNPS1/NOP56/RPS2/ODC1/EEF1B2/COPS5/KPNB1/PRPS2/PSMA7/TOMM70/TRA2B/CTPS1/RAD23B/SERBP1/C1QBP/RSL1D1/SRSF3/DDX21/PPIA/CLNS1A/HNRNPD/ILF2/SNRPA/RPL6/EXOSC7/RAN/LSM2/RPL14/MYC/CCT4/SRPK1/STARD7/CDC45/NAP1L1/RPS6/EIF2S2/KARS1/DHX15/PTGES3/SLC25A3/UBE2E1/SNRPG/LDHA/CCT5/PSMD1/ABCE1/NPM1/CUL1/CCNA2/YWHAE/GNL3/SSB/SNRPD3/VBP1/HSPD1/IARS1/PA2G4/TYMS/BUB3/EIF4E/PRDX4/XPO1/MCM6/EIF1AX/EIF4G2/RPL34/RFC4/SNRPB2/UBE2L3/TCP1/AP3S1/KPNA2/ETF1/DEK/PCNA/RANBP1/RRP9/EIF2S1/ORC2/CBX3/CNBP/XPOT/YWHAQ/SRSF2/HDAC2/SYNCRIP/VDAC1/PSMA4/GLO1/UBA2/COX5A/GOT2/HPRT1/MRPL9/PSMC6/PSMA1/USP1/ERH/IFRD1/TXNL4A/AIMP2/GSPT1/HSPE1/NDUFAB1
HALLMARK_IL6_JAK_STAT3_SIGNALING HALLMARK_IL6_JAK_STAT3_SIGNALING 80 -0.357819986797312 -0.910323330042261 0.635772698678968 1 1 2872 tags=18%, list=17%, signal=15% IRF9/PF4/CD38/LEPR/SOCS1/TNFRSF12A/IL10RB/IL13RA1/EBI3/IL7/OSMR/INHBE/DNTT/CXCL10
HALLMARK_G2M_CHECKPOINT HALLMARK_G2M_CHECKPOINT 198 -0.317721598826269 -0.904970753874623 0.7667089678511 1 1 5664 tags=36%, list=34%, signal=24% MCM3/HUS1/RAD21/CCND1/MKI67/SUV39H1/TPX2/CUL1/CCNT1/UBE2C/CENPF/CCNA2/CDC7/TRAIP/RACGAP1/MEIS2/CDK1/JPT1/MAPK14/BUB1/FANCC/MEIS1/CDKN3/TOP2A/KIF20B/TENT4A/CKS2/BUB3/STMN1/FBXO5/SMC2/BIRC5/XPO1/CUL3/MCM6/PLK4/KIF11/E2F3/KPNA2/SMC4/CCNB2/MTF2/PRC1/SQLE/SRSF2/CDC6/RPS6KA5/SMC1A/MARCKS/SYNCRIP/CDC27/DKC1/CTCF/BRCA2/PTTG1/POLQ/BARD1/HMMR/CASP8AP2/CENPE/GSPT1/PBK/AURKA/STIL/DMD/PRIM2/TTK/HIRA/DBF4/CENPA/EGF/EFNA5
HALLMARK_PEROXISOME HALLMARK_PEROXISOME 98 -0.340693122206157 -0.893714324221646 0.694975825099853 1 1 1675 tags=8%, list=10%, signal=7% DHRS3/ALB/NR1I2/CRABP2/DIO1/ABCD2/CADM1/ABCC8
HALLMARK_INFLAMMATORY_RESPONSE HALLMARK_INFLAMMATORY_RESPONSE 188 0.318624799338539 0.887559875801682 0.784738041002278 1 1 2161 tags=17%, list=13%, signal=15% LTA/HPN/VIP/EDN1/HAS2/MARCO/CCL17/CSF3/CXCL11/KCNJ2/TPBG/FFAR2/MET/APLNR/CMKLR1/IL1A/SLC7A2/GP1BA/F3/ICOSLG/CCL24/IL1R1/ABCA1/SLC4A4/CD40/RGS16/IL15RA/LPAR1/ADGRE1/P2RY2/RASGRP1/ADM
HALLMARK_UV_RESPONSE_UP HALLMARK_UV_RESPONSE_UP 154 0.318896906547614 0.869628409380144 0.816249050873197 1 1 458 tags=4%, list=3%, signal=4% BMP2/CYP1A1/CDKN2B/C4BPB/NTRK3/SHOX2
HALLMARK_TNFA_SIGNALING_VIA_NFKB HALLMARK_TNFA_SIGNALING_VIA_NFKB 199 -0.304872296580046 -0.869226425462633 0.872151898734177 1 1 2926 tags=21%, list=18%, signal=17% EGR1/CCRL2/JAG1/CCL5/PANX1/TIPARP/NINJ1/RCAN1/NFKBIE/TNFAIP6/CXCL2/ID2/NFKB2/BTG3/EGR2/NR4A3/BHLHE40/DNAJB4/CEBPB/DUSP2/HES1/MSC/BCL2A1/GEM/CLCF1/ICAM1/RHOB/TNFRSF9/PTGS2/DUSP4/ZBTB10/IL12B/SLC2A6/FJX1/CCL20/SERPINE1/TNC/CCN1/GFPT2/OLR1/CXCL10
HALLMARK_E2F_TARGETS HALLMARK_E2F_TARGETS 200 -0.303815549910775 -0.866354100037336 0.87891617273497 1 1 5833 tags=44%, list=35%, signal=29% MYC/EXOSC8/RAD51AP1/CHEK2/NAP1L1/MCM3/HUS1/NUP205/MELK/RAD21/MKI67/SUV39H1/CNOT9/PRPS1/WEE1/EED/PAICS/RACGAP1/CDK1/JPT1/CDKN3/NUDT21/TOP2A/GINS4/BUB1B/POLD3/PA2G4/CKS2/DCLRE1B/MMS22L/STMN1/TFRC/PRKDC/PRDX4/BIRC5/XPO1/MCM6/SMC6/PLK4/KPNA2/SMC4/NUP153/MSH2/RFC1/DEK/PCNA/CCNB2/RANBP1/EIF2S1/ORC2/UBE2T/DCTPP1/TCF19/RRM2/SRSF2/MTHFD2/SMC1A/RAD51C/SMC3/ASF1B/CSE1L/RBBP7/SYNCRIP/SLBP/CTCF/ATAD2/DLGAP5/UNG/POP7/CDCA8/BRCA2/PSMC3IP/PTTG1/DIAPH3/BARD1/USP1/HMMR/RPA3/DSCC1/ASF1A/DONSON/HELLS/CENPE/GSPT1/TRIP13/AURKA/PRIM2/SPC25
HALLMARK_ANGIOGENESIS HALLMARK_ANGIOGENESIS 32 -0.393596428262813 -0.863409040134241 0.686137392019745 1 1 1333 tags=16%, list=8%, signal=14% LPL/THBD/VTN/OLR1/MSX1
HALLMARK_HEDGEHOG_SIGNALING HALLMARK_HEDGEHOG_SIGNALING 36 -0.384689269241352 -0.863202078362388 0.695232223592273 1 1 1628 tags=14%, list=10%, signal=13% RTN1/SHH/L1CAM/NKX6-1/UNC5C
HALLMARK_HEME_METABOLISM HALLMARK_HEME_METABOLISM 196 0.305986626406691 0.855148849762451 0.879012345679012 1 1 2435 tags=11%, list=15%, signal=9% HBZ/ACKR1/SELENBP1/AHSP/GYPA/ACSL6/RAP1GAP/C3/MOCOS/CA1/ALAS2/OSBP2/PC/DMTN/FN3K/FTCD/RHCE/HAGH/ACP5/P4HA2/H1-0
HALLMARK_ANDROGEN_RESPONSE HALLMARK_ANDROGEN_RESPONSE 98 -0.324472441198325 -0.851163846913926 0.805549716207694 1 1 829 tags=13%, list=5%, signal=13% PGM3/ELL2/SELENOP/IDI1/KRT8/SRP19/ABCC4/ANKH/ADAMTS1/ZBTB10/STEAP4/BMPR1B/AZGP1
HALLMARK_APICAL_SURFACE HALLMARK_APICAL_SURFACE 40 -0.37070692781029 -0.846959276167778 0.726242011956298 1 1 1416 tags=22%, list=8%, signal=21% SHROOM2/GSTM3/GATA3/MAL/SRPX/SLC2A4/CX3CL1/EFNA5/SLC34A3
HALLMARK_DNA_REPAIR HALLMARK_DNA_REPAIR 148 -0.306160948532172 -0.844392100504928 0.890928270042194 1 1 4816 tags=24%, list=29%, signal=17% POLR2H/NUDT21/TAF9/POLD3/TYMS/TMED2/POLR3C/RALA/SRSF6/RFC4/EIF1B/CMPK2/PCNA/NT5C/MRPL40/TAF12/TARBP2/CANT1/UMPS/PDE6G/ARL6IP1/NT5C3A/RRM2B/HPRT1/MPC2/TAF10/RPA3/ERCC4/NPR2/POLR2K/BCAM/TAF13/POLB/AK1/CCNO/VPS37D
HALLMARK_INTERFERON_ALPHA_RESPONSE HALLMARK_INTERFERON_ALPHA_RESPONSE 97 -0.320841477905515 -0.840314181253404 0.83385711292688 1 1 3161 tags=18%, list=19%, signal=14% PSMA3/SAMD9L/TRIM5/OAS1/CCRL2/IRF9/PROCR/SAMD9/NCOA7/C1S/LAMP3/ISG15/IFI44L/IFI27/IL7/BATF2/CXCL10
HALLMARK_IL2_STAT5_SIGNALING HALLMARK_IL2_STAT5_SIGNALING 196 -0.291177179075664 -0.828483174767549 0.948701709943002 1 1 1963 tags=10%, list=12%, signal=9% SPP1/SCN9A/CCR4/EEF1AKMT1/MYO1E/SH3BGRL2/RHOB/TNFRSF9/TGM2/MUC1/DHRS3/SHE/APLP1/IL10/ITIH5/MAP6/PTH1R/GPR83/F2RL2/CXCL10
HALLMARK_HYPOXIA HALLMARK_HYPOXIA 194 0.287465400835857 0.802653623145422 0.967337637675655 1 1 2059 tags=12%, list=12%, signal=11% HAS1/PPARGC1A/LDHC/EDN2/SULT2B1/SELENBP1/ERRFI1/CA12/GCK/CAV1/GPC4/TPBG/ALDOA/PPFIA4/F3/SDC3/PGAM2/MIF/STBD1/PGF/CP/CSRP2/TMEM45A
HALLMARK_INTERFERON_GAMMA_RESPONSE HALLMARK_INTERFERON_GAMMA_RESPONSE 197 -0.27906176152195 -0.793899948309489 0.983276883996613 1 1 1882 tags=10%, list=11%, signal=9% TNFAIP6/LYSMD2/C1S/SOCS1/CFH/ARL4A/ICAM1/PTGS2/ISG15/IFI44L/CD274/IFI27/IL7/SSPN/BATF2/KLRK1/GBP6/CFB/IDO1/CXCL10
HALLMARK_GLYCOLYSIS HALLMARK_GLYCOLYSIS 191 0.277330326279178 0.773975304685705 0.98503220917014 1 1 2440 tags=15%, list=15%, signal=13% CHST6/LDHC/CLDN3/GPR87/ANG/GPC4/TPBG/MET/TGFA/HS6ST2/ALDOA/PPFIA4/LCT/SDC3/PC/PGAM2/MIF/SPAG4/NOL3/EGLN3/SDC1/CAPN5/SLC25A10/STC2/B4GALT2/EXT1/P4HA2/NT5E
HALLMARK_MYC_TARGETS_V2 HALLMARK_MYC_TARGETS_V2 57 -0.318440394844921 -0.769755609526944 0.897355819279617 1 1 5443 tags=47%, list=33%, signal=32% MYC/WDR74/RCL1/NPM1/GNL3/IPO4/GRWD1/BYSL/HSPD1/PA2G4/PLK4/NIP7/SUPV3L1/RRP9/DCTPP1/CBX3/TMEM97/TFB2M/EXOSC5/UNG/HK2/UTP20/WDR43/AIMP2/HSPE1/NDUFAF4/DUSP2
HALLMARK_ADIPOGENESIS HALLMARK_ADIPOGENESIS 194 -0.263428764431139 -0.74865560569999 0.996621621621622 1 1 2455 tags=10%, list=15%, signal=9% COX6A1/SLC66A3/JAGN1/NDUFA5/PHLDB1/ARL4A/NDUFAB1/ME1/COL15A1/PPARG/FZD4/SSPN/SNCG/LPL/MTARC2/MRAP/ADIPOQ/GPX3/ITIH5/HSPB8
HALLMARK_UNFOLDED_PROTEIN_RESPONSE HALLMARK_UNFOLDED_PROTEIN_RESPONSE 111 -0.269185414896422 -0.717421289481871 0.992003367003367 1 1 5490 tags=41%, list=33%, signal=27% EXOSC10/EXOSC2/NPM1/XBP1/DNAJA4/CEBPG/HSP90B1/HSPA9/EXOSC9/IARS1/SEC11A/LSM1/EIF4E/ERO1A/SRPRB/BAG3/ATF4/SERP1/RRP9/EIF2S1/NFYB/HERPUD1/CNOT2/XPOT/HSPA5/MTHFD2/SPCS3/PREB/SLC30A5/EXOSC5/DKC1/SDAD1/PSAT1/NFYA/CNOT6/CNOT4/SPCS1/PAIP1/DNAJC3/EIF4EBP1/EXOSC4/EIF2AK3/POP4/CEBPB/KDELR3
HALLMARK_FATTY_ACID_METABOLISM HALLMARK_FATTY_ACID_METABOLISM 146 0.264116193500027 0.715507911584325 0.995803128576879 1 1 2879 tags=12%, list=17%, signal=10% CYP1A1/ALDH3A1/INMT/PTPRG/ACADL/FMO1/ALDOA/MIF/CD1D/LTC4S/EPHX1/CEL/MLYCD/NTHL1/RDH16/CRAT/REEP6/GCDH
HALLMARK_ALLOGRAFT_REJECTION HALLMARK_ALLOGRAFT_REJECTION 189 -0.243192246418741 -0.689668588511864 0.999577435030636 1 1 1573 tags=6%, list=9%, signal=5% IL12B/CD28/IL7/NCR1/CD8A/IL11/CD247/FASLG/IL10/TGFB2/RPL3L
HALLMARK_P53_PATHWAY HALLMARK_P53_PATHWAY 197 0.244520963593379 0.684024319880532 1 1 1 3355 tags=17%, list=20%, signal=14% BMP2/TP63/CDKN2B/INHBB/TGFA/IL1A/TAX1BP3/TCHH/TPD52L1/RGS16/SDC1/IFI30/ABAT/JAG2/EPHX1/CDKN2A/PERP/EPS8L2/CDK5R1/FDXR/TM4SF1/NHLH2/RRAD/TGFB1/HSPA4L/PLXNB2/NDRG1/HBEGF/TNFSF9/SLC19A2/PLK2/ST14/DEF6
HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY 49 0.267681875777573 0.626605964682727 0.989048991354467 1 1 3629 tags=22%, list=22%, signal=18% SRXN1/SBNO2/FES/G6PD/TXNRD2/PTPA/HMOX2/ERCC2/JUNB/MPO/IPCEF1
HALLMARK_APOPTOSIS HALLMARK_APOPTOSIS 161 0.223888019232829 0.613989954042942 1 1 1 1185 tags=3%, list=7%, signal=3% BMP2/LUM/PLPPR4/F2/CAV1
HALLMARK_OXIDATIVE_PHOSPHORYLATION HALLMARK_OXIDATIVE_PHOSPHORYLATION 199 0.201069867977897 0.562376777786111 1 1 1 18 tags=1%, list=0%, signal=1% PDK4
HALLMARK_PROTEIN_SECRETION HALLMARK_PROTEIN_SECRETION 94 0.208732361541479 0.53761905583606 1 1 1 193 tags=1%, list=1%, signal=1% TSPAN8
HALLMARK_MITOTIC_SPINDLE HALLMARK_MITOTIC_SPINDLE 199 -0.188100204953471 -0.536295592005572 1 1 1 5076 tags=28%, list=30%, signal=20% RACGAP1/ALS2/YWHAE/CDK1/ANLN/LRPPRC/BUB1/SOS1/DOCK4/TOP2A/STAU1/KIF20B/PCM1/FBXO5/BIRC5/FARP1/ARL8A/KIF11/ITSN1/SMC4/RFC1/PCGF5/CCNB2/BCL2L11/PPP4R2/KIFAP3/PRC1/CDC42BPA/SMC1A/WASL/SMC3/MARCKS/CDC27/ARHGEF7/KNTC1/TLK1/KIF3C/CTTN/DLGAP5/BRCA2/PIF1/CDC42EP4/TUBD1/RAPGEF5/CENPE/CD2AP/SHROOM2/AURKA/NCK1/TTK/FGD4/MYO1E/BCAR1/SYNPO/ARHGAP29/SORBS2
HALLMARK_MTORC1_SIGNALING HALLMARK_MTORC1_SIGNALING 200 0.151399117600693 0.423853924469258 1 1 1 1453 tags=2%, list=9%, signal=2% IGFBP5/FKBP2/CYP51A1/ALDOA/CFP
paired_stranded24h/GE_ANAK_24h-GE_24h-gsea-sasp.txt
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ID Description setSize enrichmentScore NES pvalue p.adjust qvalue rank leading_edge core_enrichment
SASP_SCHLEICH SASP_SCHLEICH 72 -0.387547016140745 -0.971109402017876 0.507071547420965 0.689079054604727 0.689079054604727 1488 tags=22%, list=9%, signal=20% BHLHE40/ID1/GEM/ITGA2/ICAM1/IL7/CXCR2/CCL20/SERPINE1/EGF/NGF/IGFBP3/MMP10/CCL25/PTGES/FGF2
CLASSICAL_SASP CLASSICAL_SASP 34 -0.388676419212055 -0.863003357059923 0.689079054604727 0.689079054604727 0.689079054604727 1557 tags=24%, list=9%, signal=21% IFNB1/IL7/BGN/CCL20/SERPINE1/EGF/DCN/FGF2
paired_stranded24h/GE_ANAK_24h-GE_24h-gsea-senescence_signatures.txt
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ID Description setSize enrichmentScore NES pvalue p.adjust qvalue rank leading_edge core_enrichment
Purcell Purcell 46 -0.448418933010803 -1.05201859385196 0.364540182270091 0.728807806533729 0.728807806533729 1882 tags=17%, list=11%, signal=15% ICAM1/CD163L1/IFI27/BATF2/CCDC80/COL17A1/IDO1/CLDN1
Casella Casella 49 -0.425678649317532 -1.00671638282452 0.437199582027168 0.728807806533729 0.728807806533729 1542 tags=18%, list=9%, signal=17% SLCO2B1/RND3/SRPX2/JCAD/SRPX/CLSTN2/DIO2/CLDN1/SMCO3
SenMayo SenMayo 105 -0.371011413072123 -0.980013796494082 0.490046590427785 0.728807806533729 0.728807806533729 1998 tags=17%, list=12%, signal=15% GEM/CXCL16/SPP1/ITGA2/ICAM1/IL7/CXCR2/CCL20/VGF/EGF/IGFBP3/MMP10/IL10/CCL26/CST4/PTGES/FGF2/CXCL10
Sencan Sencan 30 -0.448697542232008 -0.974413846891742 0.49419328079635 0.728807806533729 0.728807806533729 1888 tags=37%, list=11%, signal=33% PPBP/EBI3/TREM2/COL6A5/CILP/SLAMF1/IGFL2/MMP10/COL10A1/CLCA2/CXCL10
Pribluda_SENESCENCE_INFLAMMATORY_GENES Pribluda_SENESCENCE_INFLAMMATORY_GENES 92 -0.370876020899505 -0.962883254883348 0.52057700466695 0.728807806533729 0.728807806533729 1998 tags=16%, list=12%, signal=14% GEM/ITGA2/ICAM1/NXN/IL7/LPO/CCL20/SERPINE1/IGFBP3/FAIM2/CPA2/HIF3A/OLR1/PTGES/CXCL10
FRIDMAN_SENESCENCE_UP FRIDMAN_SENESCENCE_UP 72 0.326911972400938 0.810110132996128 0.859578544061303 0.987336914811972 0.987336914811972 861 tags=6%, list=5%, signal=5% ALDH1A3/CDKN2B/IGFBP5/MMP1
Hernandez Hernandez 54 0.266956582893172 0.634791414912951 0.987336914811972 0.987336914811972 0.987336914811972 2973 tags=15%, list=18%, signal=12% GDNF/NOL3/POFUT2/P4HA2/BCL2L2/TOLLIP/PLXNA3/SLC16A3
paired_stranded24h/GE_ANAK_24h-RNP_NEG_24h-gsea-h.all.v7.2.symbols.txt
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paired_stranded24h/GE_ANAK_24h-RNP_NEG_24h-gsea-sasp.txt
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ID Description setSize enrichmentScore NES pvalue p.adjust qvalue rank leading_edge core_enrichment
CLASSICAL_SASP CLASSICAL_SASP 34 0.572294234109075 1.50354157794762 0.0318471337579618 0.0636942675159236 0.0335232986925914 2340 tags=53%, list=14%, signal=46% KITLG/EFEMP1/GDNF/CXCL1/CCL2/COL1A1/IFNB1/MMP9/BGN/CCL20/CXCL8/IL1A/SERPINE1/MMP3/FN1/FGF7/CSF1/MMP2
SASP_SCHLEICH SASP_SCHLEICH 72 0.329814613808138 0.982023528052211 0.488050314465409 0.488050314465409 0.256868586560741 3260 tags=42%, list=20%, signal=34% CSF2/KITLG/CCL1/CXCL1/CCL2/MIF/CCL20/FAS/AREG/SERPINB2/ITPKA/IGFBP4/IL1A/SERPINE1/MMP3/MMP14/MMP10/FN1/CPE/FGF7/GEM/EGF/BHLHE40/IGFBP2/TIMP1/CD9/PLAUR/CXCR2/PLAU/TGFB1
paired_stranded24h/GE_ANAK_24h-RNP_NEG_24h-gsea-senescence_signatures.txt
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ID Description setSize enrichmentScore NES pvalue p.adjust qvalue rank leading_edge core_enrichment
Purcell Purcell 46 0.582800525737968 1.61062350453097 0.00575942076682574 0.0291117388575016 0.0175108203654145 1579 tags=22%, list=9%, signal=20% CCDC80/IL32/CYP1A1/COL17A1/ATF3/C3/BATF2/IFI30/IL1A/CD163L1
FRIDMAN_SENESCENCE_UP FRIDMAN_SENESCENCE_UP 72 0.511061604461729 1.52292427683317 0.00831763967357188 0.0291117388575016 0.0175108203654145 4095 tags=46%, list=25%, signal=35% MMP1/CDKN1A/MDM2/CDKN2B/ALDH1A3/SERPINB2/IGFBP4/SERPINE1/TGFB1I1/IRF7/TFAP2A/FN1/GSN/FILIP1L/RABGGTA/RRAS/OPTN/IGFBP2/THBS1/CCND1/AOPEP/CLTB/GUK1/RHOB/VIM/SMPD1/CD44/S100A11/ISG15/RGL2/CDKN1C/HSPA2/TNFAIP3
SenMayo SenMayo 105 0.462074789986812 1.45294909082542 0.0157386785449146 0.0367235832714675 0.0220893733963714 1440 tags=26%, list=9%, signal=24% MMP1/EDN1/CSF2/IL32/KITLG/GDF15/BMP2/PGF/CCL1/CXCL1/CCL2/ANGPTL4/MIF/MMP9/VGF/CCL20/FAS/CXCL8/CCL3/C3/TNFRSF10C/PAPPA/AREG/ITPKA/INHA/CXCL3/IL1A
Sencan Sencan 30 0.400840183294514 1.02745997632464 0.426248941574936 0.666641264034954 0.40098722648719 1998 tags=43%, list=12%, signal=38% MMP1/CSF2/TAC3/EBI3/SBSN/LUM/FOLR3/CCL3/SERPINB2/IL1A/CD163/MMP3/MMP10
Casella Casella 49 0.340334017020599 0.951193739345845 0.544359433501546 0.666641264034954 0.40098722648719 3705 tags=31%, list=22%, signal=24% RND3/CLSTN2/ELMOD1/PTCHD4/TNFRSF10C/DIO2/LRP10/KIAA1671/FILIP1L/JCAD/PDLIM1/SLCO2B1/TAP1/TMEM30A/POFUT2
Pribluda_SENESCENCE_INFLAMMATORY_GENES Pribluda_SENESCENCE_INFLAMMATORY_GENES 92 0.306785882768314 0.945588937639565 0.571406797744246 0.666641264034954 0.40098722648719 1495 tags=16%, list=9%, signal=15% CSF2/CDKN1A/CXCL1/CDKN2B/TNFRSF10B/MIF/CCL20/FAS/CD14/CCL3/ITPKA/IGFBP4/CXCL3/IL1A/SERPINE1
Hernandez Hernandez 54 0.286102975966119 0.812132302824116 0.796007084205442 0.796007084205442 0.478801253657409 2249 tags=15%, list=13%, signal=13% PDLIM4/GDNF/P4HA2/PLK3/DGKA/SLC16A3/NOL3/TOLLIP
paired_stranded24h/RNP_NEG_ANAK_24h-RNP_NEG_24h-gsea-h.all.v7.2.symbols.txt
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ID Description setSize enrichmentScore NES pvalue p.adjust qvalue rank leading_edge core_enrichment
HALLMARK_APICAL_JUNCTION HALLMARK_APICAL_JUNCTION 190 0.529898601730887 1.55529019956848 0.000206398348813209 0.0103199174406605 0.0103199174406605 1519 tags=15%, list=9%, signal=14% CDH15/CDH3/PDZD3/CRB3/NFASC/VCAM1/WNK4/MADCAM1/CADM2/NRTN/CD209/ACTN3/CDH11/CLDN6/CLDN4/GRB7/SHROOM2/NECTIN4/CDH4/COL9A1/ITGA10/ACTA1/ACTG2/CD99/NRXN2/ALOX15B/CALB2/COL16A1
HALLMARK_WNT_BETA_CATENIN_SIGNALING HALLMARK_WNT_BETA_CATENIN_SIGNALING 41 -0.592610923315101 -1.3952228697155 0.0515443635648239 1 1 2302 tags=24%, list=14%, signal=21% FZD8/PSEN2/AXIN2/HEY1/DLL1/PTCH1/FRAT1/NOTCH4/WNT1/WNT6
HALLMARK_ANGIOGENESIS HALLMARK_ANGIOGENESIS 32 0.53450037502072 1.20863168072213 0.194137723348725 1 1 1520 tags=19%, list=9%, signal=17% CXCL6/COL3A1/MSX1/LUM/STC1/THBD
HALLMARK_IL6_JAK_STAT3_SIGNALING HALLMARK_IL6_JAK_STAT3_SIGNALING 80 -0.449711553596591 -1.17465374962606 0.169982272995864 1 1 1802 tags=16%, list=11%, signal=15% LTB/TNFRSF12A/ACVRL1/SOCS1/IL17RB/IL1R2/TNF/CXCL10/CNTFR/IL6/CXCL1/CXCL11/INHBE
HALLMARK_PI3K_AKT_MTOR_SIGNALING HALLMARK_PI3K_AKT_MTOR_SIGNALING 103 0.429022177988009 1.16822122705439 0.152439024390244 1 1 1276 tags=7%, list=8%, signal=6% CAMK4/SFN/FASLG/IL4/ADCY2/GNGT1/PITX2
HALLMARK_APICAL_SURFACE HALLMARK_APICAL_SURFACE 40 0.491016172544116 1.15511365170819 0.234517766497462 1 1 1747 tags=28%, list=10%, signal=25% PCSK9/RTN4RL1/NTNG1/SHROOM2/GAS1/SLC34A3/CD160/LYPD3/GHRL/SRPX/SLC2A4
HALLMARK_NOTCH_SIGNALING HALLMARK_NOTCH_SIGNALING 31 -0.500820914665494 -1.11862486182403 0.294141012909633 1 1 3368 tags=32%, list=20%, signal=26% FZD7/JAG1/ST3GAL6/LFNG/NOTCH3/PSEN2/DLL1/DTX1/HES1/WNT5A
HALLMARK_TGF_BETA_SIGNALING HALLMARK_TGF_BETA_SIGNALING 54 -0.446916437155794 -1.10245379130363 0.291279414672731 1 1 3020 tags=39%, list=18%, signal=32% ARID4B/BMPR1A/MAP3K7/TGIF1/NOG/SMURF2/SMAD1/PPM1A/ACVR1/KLF10/CDKN1C/SKI/THBS1/CDH1/ID1/SMAD7/LTBP2/SMAD6/SKIL/LEFTY2/TJP1
HALLMARK_ADIPOGENESIS HALLMARK_ADIPOGENESIS 194 0.373262594058335 1.09700753102716 0.218174291037052 1 1 3841 tags=24%, list=23%, signal=19% SNCG/LIFR/LAMA4/ME1/SSPN/ABCA1/REEP6/APOE/ITIH5/SPARCL1/SLC25A10/ALDOA/C3/NDUFB7/ESRRA/PPARG/BCKDHA/PHLDB1/TOB1/PEMT/ACADS/VEGFB/GPX4/ECH1/SQOR/PTGER3/TST/ETFB/PFKL/PREB/UCK1/CD151/SLC25A1/CRAT/CYC1/SCARB1/TKT/QDPR/MGLL/COX8A/PEX14/COQ9/UCP2/BCL6/CDKN2C/CAVIN2/JAGN1
HALLMARK_BILE_ACID_METABOLISM HALLMARK_BILE_ACID_METABOLISM 100 -0.406930646429752 -1.09568076133571 0.26928361138371 1 1 712 tags=10%, list=4%, signal=10% PEX12/EPHX2/CYP8B1/ABCA4/ABCG4/CYP7A1/ALDH8A1/CYP27A1/NR0B2/ABCD2
HALLMARK_XENOBIOTIC_METABOLISM HALLMARK_XENOBIOTIC_METABOLISM 183 -0.374671331452941 -1.08230078368299 0.254263565891473 1 1 1305 tags=11%, list=8%, signal=10% ARG2/ITIH4/PDK4/CYB5A/RBP4/DDC/CYP17A1/VTN/TGFB2/FABP1/CES1/CYP27A1/PTGES/PTGDS/HGFAC/HSD17B2/TTPA/ABCD2/F11/IGF1
HALLMARK_COAGULATION HALLMARK_COAGULATION 127 -0.387371116251198 -1.07360808848448 0.296623478602277 1 1 1766 tags=18%, list=11%, signal=16% CRIP2/C1S/PROZ/MMP7/THBS1/LGMN/TF/FN1/GP1BA/OLR1/C2/PROC/LEFTY2/SERPINC1/SERPINA1/PDGFB/CTSE/FGA/PLAT/F2RL2/APOC2/F2/F11
HALLMARK_HYPOXIA HALLMARK_HYPOXIA 194 -0.362328005553881 -1.05397677686704 0.311351769483659 1 1 2011 tags=16%, list=12%, signal=14% CHST3/TPD52/HS3ST1/VEGFA/CDKN1C/SELENBP1/BHLHE40/KDELR3/IDS/DCN/ADM/TMEM45A/GAPDHS/CAV1/GPC1/PYGM/PPFIA4/CCN2/GCK/CA12/MT1E/PDGFB/LALBA/ANGPTL4/HAS1/GPC4/IL6/STBD1/HOXB9/NCAN/TKTL1
HALLMARK_PANCREAS_BETA_CELLS HALLMARK_PANCREAS_BETA_CELLS 28 0.47585961040904 1.0521003333319 0.377019748653501 1 1 1983 tags=36%, list=12%, signal=32% CHGA/SLC2A2/PAX4/NKX6-1/PCSK1/HNF1A/MAFB/PAX6/ABCC8/PKLR
HALLMARK_FATTY_ACID_METABOLISM HALLMARK_FATTY_ACID_METABOLISM 146 0.363897851724662 1.03639267672501 0.355785123966942 1 1 2595 tags=13%, list=16%, signal=11% CA4/BMPR1B/CYP1A1/ME1/MIF/REEP6/ALDH3A1/CYP4A22/FMO1/ALDOA/SLC22A5/IL4I1/ACADS/LGALS1/ACOT2/ACOT8/MAOA/ECH1/NTHL1
HALLMARK_ANDROGEN_RESPONSE HALLMARK_ANDROGEN_RESPONSE 98 0.374634114323728 1.01255582656134 0.420999187652315 1 1 474 tags=4%, list=3%, signal=4% AZGP1/BMPR1B/SPDEF/LIFR
HALLMARK_IL2_STAT5_SIGNALING HALLMARK_IL2_STAT5_SIGNALING 196 -0.341666066699156 -0.994834580865642 0.470576848625629 1 1 2529 tags=18%, list=15%, signal=15% LRIG1/FLT3LG/MAP6/NRP1/ABCB1/CDKN1C/PRKCH/MUC1/ADAM19/MYO1E/BHLHE40/ITGA6/TNFRSF9/SPRED2/LTB/TLR7/NOP2/ENPP1/SOCS1/BATF3/PTCH1/IL1R2/DHRS3/IL13/RGS16/GPR83/SERPINC1/TNFSF11/CXCL10/PTH1R/IL10/F2RL2/DRC1/CTLA4/APLP1
HALLMARK_KRAS_SIGNALING_DN HALLMARK_KRAS_SIGNALING_DN 162 0.334306238822269 0.963888624633383 0.540518305224188 1 1 2146 tags=27%, list=13%, signal=23% EDN1/PRODH/MYH7/BMPR1B/P2RY4/MEFV/IL5/OXT/ITIH3/RYR2/EGF/TG/WNT16/DLK2/VPREB1/HTR1B/CD40LG/KCNQ2/PAX3/SCN10A/PAX4/NGB/COL2A1/KRT13/HNF1A/KCNN1/CYP39A1/SCGB1A1/MYO15A/IL12B/LYPD3/P2RX6/UPK3B/FGF16/TCL1A/CPB1/SLC12A3/CKM/SERPINB2/CCDC106/CALCB/IDUA/PDCD1
HALLMARK_MYOGENESIS HALLMARK_MYOGENESIS 180 0.329322906459046 0.960749038028542 0.557620817843866 1 1 1462 tags=14%, list=9%, signal=13% GJA5/COL4A2/MYH7/TNNC1/ACTN3/SPDEF/LDB3/CDH13/COX7A1/MB/PPP1R3C/FGF2/EFS/COL3A1/STC2/DTNA/COL1A1/SSPN/CASQ1/SGCA/ACTA1/SGCD/TNNT2/CTF1/NCAM1/GNAO1
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION 190 0.326739650532833 0.959004184242454 0.560990712074303 1 1 1805 tags=17%, list=11%, signal=15% CAP2/VCAM1/COL4A2/CXCL6/BGN/FMOD/PDLIM4/CDH11/COMP/FGF2/PTHLH/COL3A1/ECM2/MSX1/GAS1/LUM/COL1A1/NT5E/IL32/COL12A1/SLIT3/LRRC15/SGCD/TFPI2/LOXL2/COL16A1/HTRA1/PDGFRB/EFEMP2/CCN1/COL6A2/SFRP4
HALLMARK_SPERMATOGENESIS HALLMARK_SPERMATOGENESIS 116 0.339411058779654 0.939884452464947 0.590927583401139 1 1 1397 tags=12%, list=8%, signal=11% CAMK4/HBZ/PCSK1N/SHE/ODF1/ELOVL3/LDHC/DPEP3/ALOX15/CFTR/NAA11/ACTL7B/DDX25/PAPOLB
HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY 49 0.384326844088521 0.938526984210394 0.565226212213431 1 1 5141 tags=31%, list=31%, signal=21% SRXN1/JUNB/LSP1/GPX4/FTL/G6PD/ATOX1/PRDX2/FES/NDUFB4/PDLIM1/TXNRD2/HMOX2/ABCC1/SBNO2
HALLMARK_ESTROGEN_RESPONSE_EARLY HALLMARK_ESTROGEN_RESPONSE_EARLY 195 0.316917343933298 0.932034168507085 0.649151841125362 1 1 2282 tags=18%, list=14%, signal=16% BCL11B/KCNK15/LAD1/TJP3/SFN/MAPT/FOXC1/RHOD/ELOVL2/ELF3/RAB17/STC2/OLFM1/WFS1/INHBB/PDLIM3/SLC1A1/THSD4/KLK10/KRT13/TUBB2B/MSMB/CALB2/CELSR1/FRK/KRT19/SYBU/TPBG/TOB1/MYOF/WWC1/SLC22A5/KDM4B/MINDY1/MPPED2/CLDN7
HALLMARK_ESTROGEN_RESPONSE_LATE HALLMARK_ESTROGEN_RESPONSE_LATE 188 -0.317345780120535 -0.918845826081244 0.689420458965383 1 1 2142 tags=17%, list=13%, signal=15% CYP4F11/SCNN1A/TPD52L1/PERP/AREG/CXCL14/EGR3/LSR/GPER1/CAV1/PDZK1/CDH1/PRLR/PLAAT3/IL17RB/ANXA9/DHRS2/HR/RET/CELSR2/CA12/SERPINA1/SCUBE2/CALCR/OVOL2/GJB3/LTF/PLAC1/PTGES/CXCL12/CYP26B1/TFAP2C
HALLMARK_COMPLEMENT HALLMARK_COMPLEMENT 198 0.309171127178872 0.910964769421487 0.722486062358043 1 1 2602 tags=21%, list=16%, signal=18% C1QC/PCSK9/COL4A2/APOA4/CDH13/MT3/C4BPB/PLA2G7/ME1/KLKB1/GP9/ZFPM2/CD40LG/C9/PLG/F10/TMPRSS6/IRF7/PHEX/TFPI2/PRSS3/C3/CDA/CTSV/S100A12/CR2/C1QA/LCK/KCNIP3/MMP15/SERPINB2/MSRB1/BRPF3/FCN1/CTSD/SPOCK2/SERPINE1/S100A9/HSPA1A/MAFF/DGKG/F5
HALLMARK_KRAS_SIGNALING_UP HALLMARK_KRAS_SIGNALING_UP 188 0.307537179625293 0.902049832268966 0.746913580246914 1 1 1729 tags=12%, list=10%, signal=11% IL33/PCSK1N/TMEM100/EPHB2/RELN/ADGRL4/BMP2/GABRA3/GPRC5B/CSF2/PIGR/PTPRR/SNAP25/WNT7A/SPARCL1/ARG1/TNNT2/USH1C/FGF9/CLEC4A/ADAMDEC1/GFPT2/MAFB
HALLMARK_HEDGEHOG_SIGNALING HALLMARK_HEDGEHOG_SIGNALING 36 -0.388051327815782 -0.890685249182058 0.647909649296612 1 1 2584 tags=36%, list=15%, signal=31% TLE1/NRP1/VEGFA/SHH/CRMP1/HEY1/THY1/RTN1/PTCH1/CDK5R1/GLI1/UNC5C/CNTFR
HALLMARK_PROTEIN_SECRETION HALLMARK_PROTEIN_SECRETION 94 0.316875155970688 0.851378549650966 0.802353896103896 1 1 2656 tags=10%, list=16%, signal=8% SSPN/ABCA1/TSPAN8/VAMP7/SH3GL2/SGMS1/COPE/CAV2/KRT18
HALLMARK_INFLAMMATORY_RESPONSE HALLMARK_INFLAMMATORY_RESPONSE 188 0.286864600780612 0.84141424894817 0.909670781893004 1 1 2432 tags=17%, list=15%, signal=15% EDN1/CXCL6/MEFV/VIP/LTA/HPN/ICOSLG/ABCA1/CCL2/PCDH7/CXCR6/SLC28A2/NDP/MARCO/IRF7/LAMP3/CD14/NMUR1/MSR1/IL12B/IL1R1/LCK/FFAR2/TPBG/OSMR/EBI3/CCRL2/SCN1B/SERPINE1/IL10RA/CCR7/INHBA
HALLMARK_UV_RESPONSE_DN HALLMARK_UV_RESPONSE_DN 141 -0.296450373890538 -0.8315820857484 0.885420705699884 1 1 2500 tags=20%, list=15%, signal=17% NRP1/APBB2/AGGF1/INPP4B/RASA2/BHLHE40/NEK7/ERBB2/PRKCE/PIK3R3/MAGI2/CAV1/DDAH1/ID1/PTPN21/SCN8A/COL1A2/FBLN5/IRS1/SMAD7/MET/LPAR1/MT1E/ADGRL2/BDNF/TJP1/IGFBP5/PTGFR
HALLMARK_UV_RESPONSE_UP HALLMARK_UV_RESPONSE_UP 154 0.290176113189334 0.831071927582352 0.904821022139458 1 1 2881 tags=19%, list=17%, signal=16% CDKN2B/BMP2/CYP1A1/C4BPB/SLC6A12/MSX1/OLFM1/FGF18/PDLIM3/COL2A1/FMO1/ALDOA/TCHH/GAL/CTSV/H2AX/MRPL23/SPR/JUNB/GRINA/NAT1/MAOA/HSPA2/HLA-F/CDC34/BSG/TST/HTR7/IGFBP2/KCNH2
HALLMARK_APOPTOSIS HALLMARK_APOPTOSIS 161 -0.289179534456507 -0.823969048808464 0.91495145631068 1 1 2068 tags=12%, list=12%, signal=11% ERBB2/BIK/EREG/BCL2L11/BIRC3/DCN/EGR3/PPP2R5B/TNFRSF12A/CAV1/FEZ1/IGFBP6/SMAD7/TNF/GUCY2D/TGFB2/PLAT/ERBB3/IL6/F2
HALLMARK_TNFA_SIGNALING_VIA_NFKB HALLMARK_TNFA_SIGNALING_VIA_NFKB 199 -0.28021856216783 -0.816706686522447 0.950426026336173 1 1 2728 tags=21%, list=16%, signal=18% KLF9/CEBPB/TUBB2A/JUN/B4GALT5/SLC2A6/PTGS2/FOSL1/BTG2/KLF10/VEGFA/IL1A/FOSB/TRIB1/BHLHE40/PDE4B/GEM/AREG/PTX3/FJX1/BIRC3/EGR3/SLC16A6/TNFRSF9/CLCF1/IFIH1/CXCL2/TNFAIP6/HES1/OLR1/TNF/SPSB1/KLF2/MSC/CCL4/CCL20/SIK1/CXCL10/TNC/IL6/CXCL1/CXCL11
HALLMARK_ALLOGRAFT_REJECTION HALLMARK_ALLOGRAFT_REJECTION 189 -0.281095783868363 -0.814721218074637 0.950116459627329 1 1 1806 tags=11%, list=11%, signal=10% IL15/LTB/GZMB/CDKN2A/THY1/FCGR2B/SOCS1/CD96/CD247/TNF/IL13/IL12A/C2/TGFB2/CD28/CCL4/NOS2/PRKCG/IL10/IL6/F2
HALLMARK_CHOLESTEROL_HOMEOSTASIS HALLMARK_CHOLESTEROL_HOMEOSTASIS 72 0.314197020392746 0.812087974052058 0.85323332657612 1 1 4639 tags=26%, list=28%, signal=19% MAL2/AVPR1A/GLDC/ERRFI1/PPARG/ECH1/MVK/MVD/TRIB3/SEMA3B/ETHE1/FBXO6/FASN/CLU/LPL/LGALS3/TM7SF2/PNRC1/ACTG1
HALLMARK_GLYCOLYSIS HALLMARK_GLYCOLYSIS 191 -0.265461739596321 -0.770729431385311 0.986638264910922 1 1 2429 tags=12%, list=15%, signal=10% VEGFA/CTH/CLN6/HOMER1/POLR3K/KDELR3/ANG/BIK/DSC2/DCN/GAPDHS/GPC1/CYB5A/PFKFB1/PPFIA4/CHST6/HS6ST2/MET/CLDN9/ANGPTL4/GPC4/CHST4/TKTL1
HALLMARK_P53_PATHWAY HALLMARK_P53_PATHWAY 197 0.260176163346982 0.76631324742724 0.991331269349845 1 1 2299 tags=10%, list=14%, signal=8% SFN/EPHA2/CDKN2B/BMP2/CDH13/NUPR1/INHBB/OSGIN1/ALOX15B/TCHH/GLS2/TCN2/AK1/TOB1/RAB40C/CTSD/FDXR/PITPNC1/RPL36
HALLMARK_HEME_METABOLISM HALLMARK_HEME_METABOLISM 196 0.249597244409483 0.734447339302532 0.997725392886683 1 1 2309 tags=10%, list=14%, signal=8% HBZ/GYPA/SLC30A10/PDZK1IP1/TSPO2/RHD/RAP1GAP/MOCOS/FTCD/ABCB6/C3/PC/DMTN/TMCC2/MARCHF2/FN3K/XK/PIGQ/SLC66A2
HALLMARK_PEROXISOME HALLMARK_PEROXISOME 98 -0.259371735760668 -0.696269699771875 0.988578180385979 1 1 2730 tags=16%, list=16%, signal=14% BCL10/CEL/SLC23A2/IDI1/ISOC1/PEX11B/ABCB1/CLN6/EHHADH/ABCB4/DHRS3/CRABP2/EPHX2/HSD11B2/ESR2/ABCD2
HALLMARK_G2M_CHECKPOINT HALLMARK_G2M_CHECKPOINT 198 -0.21757346690106 -0.633795372333534 1 1 1 5942 tags=42%, list=36%, signal=27% ATF5/AURKB/TFDP1/CUL3/BUB1/CCND1/PAFAH1B1/SNRPD1/ODC1/NASP/WRN/STMN1/TENT4A/FBXO5/FOXN3/NUSAP1/PRPF4B/CDC45/HMGB3/NOTCH2/MAPK14/XPO1/E2F3/CENPF/PRIM2/H2AZ2/DKC1/KIF20B/MTF2/KPNA2/TPX2/NSD2/NUP50/CUL1/CASP8AP2/SRSF10/SMC4/EWSR1/PTTG1/MAP3K20/RBL1/TMPO/RACGAP1/KNL1/HNRNPD/SMC1A/HMGN2/NDC80/G3BP1/BRCA2/ORC6/BCL3/SYNCRIP/SFPQ/TNPO2/RASAL2/CUL4A/TOP1/MEIS2/H2BC12/CDC25A/CTCF/KPNB1/HNRNPU/SLC12A2/POLQ/SRSF1/SLC7A1/KIF23/YTHDC1/SLC38A1/MEIS1/SS18/EZH2/TLE3/NCL/CHEK1/LMNB1/CBX1/MT2A/RPS6KA5/PDS5B/EFNA5
HALLMARK_MYC_TARGETS_V1 HALLMARK_MYC_TARGETS_V1 199 -0.210068328858256 -0.612251406465998 1 1 1 6889 tags=50%, list=41%, signal=30% SRSF2/SNRPA1/NOLC1/CSTF2/RNPS1/UBE2E1/RPL22/ETF1/HPRT1/RRM1/RFC4/MCM7/SMARCC1/RPL6/MRPL9/PSMD14/MCM4/TRA2B/CNBP/VDAC1/TXNL4A/PGK1/RAD23B/LDHA/TFDP1/EIF4A1/PSMA4/EXOSC7/SERBP1/SNRPD1/PSMA7/USP1/ODC1/UBE2L3/EPRS1/CDC45/DDX21/DEK/CCT5/NME1/VBP1/NOP56/XPO1/PA2G4/EIF2S2/ERH/NAP1L1/UBA2/KPNA2/PABPC4/SNRPD3/RPS6/HSPD1/DDX18/TOMM70/SRPK1/HNRNPA1/CUL1/SNRPB2/PSMD1/AP3S1/CANX/ACP1/CDK2/HSP90AB1/C1QBP/EIF2S1/HNRNPD/RAN/RANBP1/FBL/STARD7/G3BP1/PRPS2/SNRPD2/EIF1AX/CTPS1/SYNCRIP/GNL3/SSBP1/KPNB1/YWHAE/HNRNPU/SRSF1/HNRNPC/SSB/EIF4E/HNRNPR/GLO1/SET/HNRNPA2B1/SRSF3/NCBP2/HSPE1/PSMA6/SNRPG/TARDBP/HNRNPA3/RPS10
HALLMARK_INTERFERON_ALPHA_RESPONSE HALLMARK_INTERFERON_ALPHA_RESPONSE 97 -0.224643710034559 -0.60216837079862 0.99980280023664 1 1 1809 tags=7%, list=11%, signal=6% IFI44L/IL15/IFIH1/C1S/IFI30/CXCL10/CXCL11
HALLMARK_UNFOLDED_PROTEIN_RESPONSE HALLMARK_UNFOLDED_PROTEIN_RESPONSE 111 0.218711389708783 0.60153662923301 1 1 1 4806 tags=20%, list=29%, signal=14% STC2/CCL2/WFS1/H2AX/EXOSC4/EEF2/PREB/EDC4/ZBTB17/YIF1A/NHP2/EXOC2/EXOSC5/LSM4/GEMIN4/EIF4EBP1/KHSRP/WIPI1/XBP1/SPCS1/POP4/SLC7A5
HALLMARK_INTERFERON_GAMMA_RESPONSE HALLMARK_INTERFERON_GAMMA_RESPONSE 197 -0.199608370227391 -0.581132922530951 1 1 1 2935 tags=14%, list=18%, signal=11% USP18/IFNAR2/IRF9/CD40/HERC6/HLA-G/NOD1/APOL6/MT2A/EPSTI1/AUTS2/PTGS2/ISOC1/MX1/PDE4B/IFI44L/IL15/IFIH1/C1S/TNFAIP6/SOCS1/CMKLR1/IFI30/CXCL10/IL6/CXCL11/GBP6
HALLMARK_OXIDATIVE_PHOSPHORYLATION HALLMARK_OXIDATIVE_PHOSPHORYLATION 199 0.195833740446689 0.577328135847107 1 1 1 6083 tags=36%, list=36%, signal=23% NDUFB7/NDUFS7/BCKDHA/ATP5F1D/MRPS12/TIMM13/GPX4/OGDH/RHOT2/ECH1/NDUFS8/ETFB/ATP6V0C/CYC1/MRPS30/TCIRG1/SURF1/CYB5R3/COX8A/ATP6V0B/NDUFC1/MRPS11/NDUFA3/ECI1/SLC25A5/SLC25A11/ABCB7/VDAC2/SLC25A20/ALDH6A1/NDUFB4/IDH2/TIMM9/PDHB/FH/NDUFV1/UQCRB/ATP5F1C/ATP5MC3/ATP6V0E1/UQCRQ/RHOT1/PDHX/MDH2/PMPCA/ACAA1/NDUFB2/ATP5F1B/COX5B/MDH1/OXA1L/ACO2/PRDX3/HTRA2/MTX2/NDUFS4/ATP6V1G1/UQCRC1/PHB2/HSD17B10/TIMM8B/COX7A2/ETFA/FDX1/UQCRC2/NDUFS3/ATP5MC2/MGST3/UQCRFS1/NDUFB5/TIMM50/MRPL15
HALLMARK_E2F_TARGETS HALLMARK_E2F_TARGETS 200 -0.195167936706172 -0.569020163231209 1 1 1 5791 tags=38%, list=35%, signal=25% USP1/CNOT9/NASP/STMN1/DIAPH3/NUDT21/TIMELESS/DCK/CBX5/PPP1R8/TCF19/RFC2/HMGB3/CIT/CCNE1/MTHFD2/DEK/NME1/NOP56/XPO1/PA2G4/RFC3/PRIM2/NAP1L1/PRKDC/UNG/KPNA2/PSIP1/SMC4/GINS1/PTTG1/TMPO/SSRP1/RACGAP1/EXOSC8/NUP107/SPC25/PPM1D/EIF2S1/ATAD2/HNRNPD/MRE11/RAN/RANBP1/LYAR/SMC1A/BRCA1/SMC6/SPC24/BRCA2/LUC7L3/ORC6/CTPS1/SYNCRIP/HMGB2/SMC3/CDC25A/CTCF/BRMS1L/MMS22L/DEPDC1/MELK/SRSF1/WEE1/EZH2/DONSON/CHEK2/PNN/CHEK1/LMNB1/RPA3/POLD3/RNASEH2A/PDS5B/HELLS/ANP32E/CDKN2A
HALLMARK_DNA_REPAIR HALLMARK_DNA_REPAIR 148 0.194384778440613 0.55408099790898 1 1 1 5145 tags=31%, list=31%, signal=22% PDE6G/NME3/MPG/CDA/AK1/POLR2E/APRT/NT5C/GPX4/POLD1/EIF1B/POLR2I/TAF12/TARBP2/CANT1/DGUOK/ERCC5/PRIM1/SURF1/ADRM1/GTF2F1/POLL/CLP1/VPS37B/NME4/GUK1/VPS28/ELL/POLR2G/GTF3C5/DAD1/RAE1/NELFE/POLR1D/ADA/POLR3GL/EDF1/STX3/ERCC1/IMPDH2/DDB2/DCTN4/PCNA/LIG1/ITPA/POLD4
HALLMARK_MTORC1_SIGNALING HALLMARK_MTORC1_SIGNALING 200 -0.154660841191414 -0.450920056775041 1 1 1 6163 tags=41%, list=37%, signal=26% CACYBP/GSK3B/PGK1/LDHA/PRDX1/INSIG1/ARPC5L/RRM2/ATP2A2/PSMA4/BUB1/PNO1/PITPNB/POLR3G/SLC1A4/GLRX/EPRS1/ATP6V1D/IMMT/HMGCR/TES/GSR/NAMPT/STIP1/MTHFD2/GTF2H1/TXNRD1/EDEM1/ADIPOR2/GCLC/CD9/EIF2S2/PDAP1/CCT6A/NIBAN1/USO1/UNG/HSPD1/TCEA1/HMGCS1/HSP90B1/MTHFD2L/TBK1/HSPA9/ACTR3/HSPA5/CANX/YKT6/ATP5MC1/ELOVL6/CXCR4/TUBA4A/ACTR2/P4HA1/BCAT1/SDF2L1/HK2/AK4/SLC7A11/PSMC2/STARD4/CDC25A/HSPA4/UFM1/PLOD2/SCD/DHFR/MLLT11/IDI1/BTG2/CYB5B/HSPE1/CTH/PSAT1/BHLHE40/ASNS/FKBP2/PIK3R3/LGMN/CYP51A1/IFI30/IGFBP5
HALLMARK_MITOTIC_SPINDLE HALLMARK_MITOTIC_SPINDLE 199 -0.135098271983572 -0.393748584008964 1 1 1 5704 tags=36%, list=34%, signal=24% SSH2/ROCK1/DST/FBXO5/AKAP13/ECT2/RABGAP1/RALBP1/NUSAP1/NIN/STAU1/NOTCH2/CNTRL/SASS6/ABI1/CDC42BPA/STK38L/RICTOR/CENPF/ARHGEF2/KIF20B/CEP192/CDC42EP4/TAOK2/TPX2/CDK5RAP2/ARHGEF12/SMC4/TUBD1/CEP57/SOS1/SYNPO/ARHGAP29/WASL/RACGAP1/CDC42/TUBA4A/TUBGCP3/SMC1A/NDC80/HOOK3/BRCA2/EPB41L2/TUBGCP5/TIAM1/RASAL2/SMC3/YWHAE/ITSN1/ARF6/FGD4/KIF23/LATS1/EPB41/CLIP1/RANBP9/CENPJ/LMNB1/PKD2/ARFGEF1/PPP4R2/RASA2/ARAP3/MYO1E/DYNLL2/CDC42EP1/BCL2L11/SHROOM1/MID1/CDC42EP2/SORBS2
HALLMARK_MYC_TARGETS_V2 HALLMARK_MYC_TARGETS_V2 57 -0.153106597764692 -0.380639807173753 1 1 1 14152 tags=26%, list=85%, signal=4% NOP56/PA2G4/UNG/HSPD1/DDX18/SUPV3L1/HK2/MPHOSPH10/GNL3/NDUFAF4/NIP7/WDR43/MAP3K6/HSPE1/NOP2
paired_stranded24h/RNP_NEG_ANAK_24h-RNP_NEG_24h-gsea-sasp.txt
0 → 100755
View file @
f9b173e7
ID Description setSize enrichmentScore NES pvalue p.adjust qvalue rank leading_edge core_enrichment
SASP_SCHLEICH SASP_SCHLEICH 72 -0.560409946546044 -1.44325193396413 0.0235362769889127 0.0470725539778253 0.0247750284093817 2076 tags=32%, list=12%, signal=28% BHLHE40/ANG/GEM/CXCR2/AREG/EREG/CCL1/IL15/CXCL2/ID1/FN1/IGFBP6/IL13/CCL20/PLAT/IL6/PTGES/CXCL1/CXCL12/IGFBP5/TNFRSF11B/CSF3/IGF1
CLASSICAL_SASP CLASSICAL_SASP 34 0.417458810328154 0.954072891210472 0.533171028606208 0.533171028606208 0.280616330845373 890 tags=24%, list=5%, signal=22% BGN/EFEMP1/FGF2/EGF/COL1A1/CCL2/FGF7/KITLG
paired_stranded24h/RNP_NEG_ANAK_24h-RNP_NEG_24h-gsea-senescence_signatures.txt
0 → 100755
View file @
f9b173e7
ID Description setSize enrichmentScore NES pvalue p.adjust qvalue rank leading_edge core_enrichment
Pribluda_SENESCENCE_INFLAMMATORY_GENES Pribluda_SENESCENCE_INFLAMMATORY_GENES 92 -0.500094131815238 -1.33056000562771 0.0509566575556423 0.356696602889496 0.356696602889496 2442 tags=26%, list=15%, signal=22% RPS6KA5/IL1A/MX1/BHLHE40/ANG/GEM/HIF3A/IL15/CXCL2/ID1/AXL/HAMP/OLR1/IGFBP6/IL13/NXN/CCL20/CXCL10/IL6/PTGES/CXCL1/CCDC33/IGFBP5/IGF1
Sencan Sencan 30 -0.586906266747294 -1.29882498069679 0.117670602361417 0.365587227716373 0.365587227716373 1182 tags=27%, list=7%, signal=25% COL6A5/SLAMF1/CXCL10/SBSN/CILP/IL6/CXCL11/SAA2
SenMayo SenMayo 105 -0.433824302327394 -1.17307448042399 0.156680240449874 0.365587227716373 0.365587227716373 2076 tags=29%, list=12%, signal=25% ANG/GEM/CXCR2/AREG/EREG/CCL24/CCL1/IL15/CXCL2/TNFRSF10C/AXL/CXCL16/SEMA3F/IGFBP6/TNF/IL13/CCL4/CCL20/CXCL10/ANGPTL4/VEGFC/IL10/PLAT/IL6/PTGES/CXCL1/CXCL12/IGFBP5/TNFRSF11B/IGF1
Purcell Purcell 46 0.458549012929553 1.11171119590308 0.280990058835464 0.491732602962061 0.491732602962061 1813 tags=20%, list=11%, signal=17% CCDC80/CYP1A1/BATF2/IL32/CD163L1/IDO1/C3/OASL/ISG20
Casella Casella 49 0.351787212990861 0.861419947906991 0.722584590297595 0.933103588080276 0.933103588080276 2006 tags=14%, list=12%, signal=13% RND3/DIO2/SRPX2/CLSTN2/SRPX/TMSB15A/JCAD
FRIDMAN_SENESCENCE_UP FRIDMAN_SENESCENCE_UP 72 -0.300975623389281 -0.771739289602424 0.911804878048781 0.933103588080276 0.933103588080276 2059 tags=15%, list=12%, signal=13% IGSF3/CXCL14/CDKN2A/THBS1/COL1A2/FN1/RAB13/IGFBP6/CCN2/ALDH1A3/IGFBP5
Hernandez Hernandez 54 0.296603244918291 0.737725756003413 0.933103588080276 0.933103588080276 0.933103588080276 3586 tags=17%, list=21%, signal=13% PDLIM4/NOL3/TOLLIP/SLC16A3/POFUT2/PCIF1/DDA1/B4GALT7/ZNHIT1
unstrand_96h/GE_96h-RNP_NEG_96h-gsea-h.all.v7.2.symbols.txt
0 → 100755
View file @
f9b173e7
ID Description setSize enrichmentScore NES pvalue p.adjust qvalue rank leading_edge core_enrichment
HALLMARK_INFLAMMATORY_RESPONSE HALLMARK_INFLAMMATORY_RESPONSE 189 0.551989760987968 1.58756548543858 0.000512360701934162 0.0256180350967081 0.0221124092413691 2368 tags=30%, list=14%, signal=26% SLC1A2/MET/CXCL11/CXCL10/TPBG/LTA/IL12B/CCL7/HPN/CD70/CDKN1A/EDN1/CCL22/EBI3/TNFSF9/ICOSLG/KCNMB2/HAS2/RGS16/KCNJ2/RGS1/TNFSF15/TACR1/CCL2/CXCL8/AQP9/IL10/INHBA/TLR3/TNFAIP6/TNFRSF9/IL1R1/CMKLR1/GPC3/CCL5/SLC28A2/LIF/FPR1/IL10RA/CSF1/OPRK1/IL7R/SERPINE1/C5AR1/CCL24/TIMP1/IL18RAP/IL18R1/ITGB3/CD14/NLRP3/PTGIR/IL15/CXCR6/SGMS2/KLF6
HALLMARK_KRAS_SIGNALING_UP HALLMARK_KRAS_SIGNALING_UP 181 0.516920047340629 1.48185417853791 0.00309318211109679 0.0378967314069162 0.0327108628986013 2285 tags=28%, list=14%, signal=24% CPE/PTPRR/APOD/CXCL10/PLEK2/SPARCL1/ALDH1A2/ANXA10/PEG3/IGFBP3/KIF5C/PIGR/EPHB2/PLAT/CSF2/BTC/RGS16/MMP9/MALL/INHBA/HSD11B1/SEMA3B/NRP1/ETV4/TMEM158/CLEC4A/ANGPTL4/CMKLR1/MAFB/PDCD1LG2/TRAF1/PTGS2/PPBP/ADGRL4/CIDEA/SCG5/BIRC3/LIF/IL10RA/KLF4/TMEM176B/IL7R/MMP11/ADAM8/TMEM176A/TNFAIP3/H2BC3/SLPI/RETN/CROT
HALLMARK_TNFA_SIGNALING_VIA_NFKB HALLMARK_TNFA_SIGNALING_VIA_NFKB 199 0.511822414342361 1.47947154987274 0.00203071455768499 0.0378967314069162 0.0327108628986013 3441 tags=41%, list=21%, signal=33% CXCL11/CXCL10/IL12B/CDKN1A/EDN1/TNFSF9/ICOSLG/NR4A1/CSF2/PLPP3/IL23A/CCL2/CXCL3/CCL4/IFIH1/NR4A2/INHBA/ATF3/TNFAIP6/TNFRSF9/TRAF1/DUSP5/KLF2/PLK2/CCL5/PTGS2/CCND1/BIRC3/LIF/KLF4/CSF1/EGR3/BCL3/IL7R/LAMB3/SERPINE1/KDM6B/BHLHE40/TNFAIP3/CCN1/DUSP4/ACKR3/BCL2A1/SGK1/GADD45A/PMEPA1/CXCL1/RNF19B/KLF6/NFIL3/CD69/RELB/CEBPD/CXCL2/EGR1/PHLDA1/IER5/PLAUR/KYNU/PTPRE/SAT1/ATP2B1/NFKBIA/JUN/IER2/CFLAR/ID2/ABCA1/FOS/PHLDA2/CD44/PTGER4/SOD2/NR4A3/DRAM1/MXD1/BTG2/TNF/YRDC/FOSL1/PPP1R15A
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION 179 0.51263371794644 1.4683128542829 0.00309637466133402 0.0378967314069162 0.0327108628986013 2245 tags=31%, list=14%, signal=27% CADM1/COL12A1/GREM1/NNMT/SCG2/BGN/THBS2/COMP/CDH6/COL1A1/PCOLCE2/SLIT3/DCN/IGFBP3/FZD8/APLP1/EDIL3/WNT5A/LAMA1/MFAP5/CDH2/ACTA2/LAMA2/HTRA1/CCN2/ITGB5/CXCL8/MYL9/PDLIM4/INHBA/SDC1/SLC6A8/TGFBI/TPM2/COL1A2/LUM/CAP2/LRP1/NT5E/ADAM12/SPOCK1/ABI3BP/THBS1/SERPINE1/TNFAIP3/CCN1/LAMA3/VCAN/TIMP1/GADD45A/DPYSL3/ITGB3/TGFBR3/PMEPA1/CXCL1/MAGEE1
HALLMARK_E2F_TARGETS HALLMARK_E2F_TARGETS 200 -0.441707605772717 -1.44501087020364 0.00378967314069162 0.0378967314069162 0.0327108628986013 6196 tags=62%, list=38%, signal=39% CBX5/CNOT9/H2AZ1/LMNB1/RAD51AP1/POLD3/MCM7/ASF1B/KIF22/PHF5A/RAD51C/SYNCRIP/ATAD2/SNRPB/RPA3/PAICS/SMC6/PRIM2/RPA1/PRPS1/SUV39H1/SPC25/RFC2/PPM1D/PRDX4/RBBP7/HMGB3/NOLC1/CDCA8/BUB1B/PSMC3IP/TK1/TFRC/MCM4/STAG1/TUBB/KPNA2/DUT/NUP205/HELLS/RACGAP1/RAN/UBE2T/MLH1/TOP2A/NCAPD2/BARD1/HMMR/PLK1/RAD1/MMS22L/XRCC6/PRKDC/CHEK1/SHMT1/MSH2/CDK4/ASF1A/ORC2/MTHFD2/CKS2/DEK/UBR7/ZW10/CHEK2/CDC25B/CDKN2C/CSE1L/RNASEH2A/KIF18B/RRM2/EXOSC8/KIF2C/NBN/DSCC1/RPA2/EIF2S1/RAD21/SMC1A/CKS1B/USP1/CDC20/UNG/TRIP13/TUBG1/SMC4/CCNB2/DONSON/TCF19/PDS5B/SRSF1/GINS3/KIF4A/CDKN3/DIAPH3/MCM2/SPAG5/SRSF2/GSPT1/DLGAP5/MCM3/MCM6/ING3/NUDT21/MAD2L1/RAD50/GINS1/PLK4/DCLRE1B/TMPO/MYC/LBR/MELK/DEPDC1/TIPIN/ANP32E/UBE2S/RFC3/CDK1/E2F8/PAN2/BRMS1L/DCK/AURKA/SLBP
HALLMARK_HYPOXIA HALLMARK_HYPOXIA 192 0.499199653503444 1.43802390266475 0.00471457696228338 0.0392881413523615 0.0339118693778278 3098 tags=31%, list=19%, signal=26% MT1E/STC1/PPP1R3C/GCK/BGN/CHST3/TPBG/GPC4/LALBA/ERRFI1/TKTL1/CDKN1A/CAVIN3/DCN/LARGE1/IGFBP3/SELENBP1/CCN5/CCN2/SDC2/ATF3/TGFBI/SDC3/ANGPTL4/KDELR3/GPC3/HAS1/P4HA2/CP/PHKG1/MIF/HMOX1/SERPINE1/BHLHE40/TNFAIP3/CCN1/DTNA/TGFB3/ACKR3/LDHC/DDIT4/CAVIN1/KLF6/NFIL3/DDIT3/B3GALT6/HS3ST1/CDKN1C/CAV1/PIM1/PLAUR/JUN/PLIN2/CA12/NAGK/AKAP12/FOS/TPST2/PPARGC1A/MT2A
HALLMARK_HEDGEHOG_SIGNALING HALLMARK_HEDGEHOG_SIGNALING 32 0.705458364762181 1.6009303138878 0.00657261942930426 0.0469472816378876 0.0405229167821767 1348 tags=25%, list=8%, signal=23% HEY1/SCG2/GLI1/ACHE/PTCH1/NRCAM/SHH/NRP1
HALLMARK_MYC_TARGETS_V1 HALLMARK_MYC_TARGETS_V1 199 -0.425262198964257 -1.39085348159425 0.00800753650494583 0.0500471031559114 0.0431985521977341 6296 tags=55%, list=38%, signal=35% PSMA4/TUFM/LSM2/HSPD1/EIF1AX/CBX3/CCT4/H2AZ1/ETF1/VDAC1/MCM7/EIF3J/SSB/MRPL9/RAD23B/SYNCRIP/STARD7/EIF2S2/GNL3/SNRPD1/SNRPG/FAM120A/CCT3/NOP16/PSMD8/CNBP/MRPL23/ILF2/PSMA6/ERH/DDX21/PRDX4/NOLC1/CANX/VDAC3/MRPS18B/POLE3/NPM1/CCT5/MCM4/KPNA2/DUT/KPNB1/RAN/PWP1/EPRS1/NCBP2/EIF4H/IARS1/TARDBP/XRCC6/PSMD14/AP3S1/PCBP1/EIF4G2/IFRD1/SERBP1/SF3A1/CDK4/ORC2/SNRPA/DEK/PSMD3/TCP1/CYC1/SLC25A3/APEX1/RFC4/CSTF2/GOT2/PGK1/ACP1/COPS5/TFDP1/UBE2E1/HNRNPA2B1/HDAC2/CLNS1A/EIF2S1/TXNL4A/USP1/RRM1/XPOT/CDC20/HPRT1/PTGES3/CDC45/HNRNPR/VBP1/SRSF1/DHX15/MCM2/SRSF2/GSPT1/PRDX3/LDHA/ODC1/TYMS/BUB3/MCM6/MAD2L1/PSMA1/EIF4E/YWHAQ/PRPS2/MYC/ABCE1/TOMM70/UBA2/CCNA2
HALLMARK_MYOGENESIS HALLMARK_MYOGENESIS 179 0.453631052270982 1.29931427027388 0.0392207457102309 0.217893031723505 0.188076090540289 2517 tags=30%, list=15%, signal=25% APOD/SPDEF/GJA5/PPP1R3C/MYL3/HRC/COL1A1/DMD/MYOG/ACTN3/MB/CDKN1A/MYH8/LARGE1/IGFBP3/ACHE/SH3BGR/PTGIS/SLN/LAMA2/MYH4/TNNT3/ITGB5/REEP1/RYR1/SCHIP1/ADCY9/SLC6A8/ACTN2/TPM2/KLF5/PVALB/FST/TNNT1/TNNI1/DENND2B/ADAM12/MYH3/ERBB3/BHLHE40/MAPRE3/TNNC1/TNNC2/DTNA/PLXNB2/KIFC3/CTF1/CFD/CKM/COL15A1/KCNH1/GPX3/NOTCH1
HALLMARK_WNT_BETA_CATENIN_SIGNALING HALLMARK_WNT_BETA_CATENIN_SIGNALING 40 0.582340720127416 1.36943298730705 0.0651593656775004 0.25206431986093 0.217571307669434 857 tags=12%, list=5%, signal=12% HEY1/DKK4/FZD8/AXIN2/PTCH1
HALLMARK_IL6_JAK_STAT3_SIGNALING HALLMARK_IL6_JAK_STAT3_SIGNALING 80 0.510523739618186 1.33487274487019 0.0621656787624693 0.25206431986093 0.217571307669434 3398 tags=35%, list=21%, signal=28% CXCL11/CXCL10/CCL7/EBI3/CXCL13/CSF2/CXCL3/IL1R1/ACVRL1/CSF1/HMOX1/CD38/PF4/IL18R1/IL10RB/ITGB3/CXCL1/CD14/IL1R2/IL2RA/IRF9/PIM1/JUN/IL13RA1/CD44/CD9/OSMR/TNF
HALLMARK_PEROXISOME HALLMARK_PEROXISOME 99 0.484794925487196 1.30170391670256 0.0655367231638418 0.25206431986093 0.217571307669434 2735 tags=20%, list=17%, signal=17% CADM1/ABCC8/HSD11B2/TTR/CRABP2/SCGB1A1/ALB/EPHX2/CACNA1B/DHRS3/DIO1/SEMA3C/CRABP1/HRAS/MLYCD/HSD3B7/CEL/ABCB4/MVP/DLG4
HALLMARK_APOPTOSIS HALLMARK_APOPTOSIS 161 0.453408631425015 1.28498435996139 0.0513766302199974 0.25206431986093 0.217571307669434 3485 tags=29%, list=21%, signal=23% BGN/PLPPR4/CDKN1A/FEZ1/DCN/PLAT/FDXR/AIFM3/ATF3/F2/CCND1/LUM/BIRC3/BAX/EGR3/CCNA1/HMOX1/CD38/ERBB3/GPX1/LMNA/TIMP1/GADD45A/TGFBR3/CD14/CTH/DDIT3/DIABLO/LGALS3/GPX3/CD69/EMP1/PSEN2/CAV1/IGFBP6/SAT1/JUN/CFLAR/PPP3R1/GSN/CD44/SOD2/BTG2/TNF/PRF1/NEDD9/PDGFRB
HALLMARK_MYC_TARGETS_V2 HALLMARK_MYC_TARGETS_V2 57 -0.480802696954533 -1.3193197152195 0.0807899461400359 0.2885355219287 0.249051713664772 6555 tags=61%, list=40%, signal=37% MAP3K6/NOP2/EXOSC5/HSPD1/CBX3/RRP12/GNL3/IMP4/NOP16/TFB2M/PPRC1/NDUFAF4/IPO4/NOLC1/HK2/LAS1L/NPM1/MCM4/RABEPK/BYSL/PLK1/CDK4/RCL1/WDR43/SLC19A1/UNG/WDR74/SORD/NIP7/PRMT3/PLK4/SLC29A2/MYC/TMEM97/PPAN
HALLMARK_APICAL_JUNCTION HALLMARK_APICAL_JUNCTION 182 0.426165560428279 1.22276374389288 0.0912831061969658 0.304277020656553 0.262639112566709 1849 tags=18%, list=11%, signal=16% NFASC/NECTIN3/CRB3/SHROOM2/CADM3/CLDN18/CDH6/CADM2/PDZD3/ACTN3/CLDN6/ADAM23/CDH4/PPP2R2C/SGCE/ATP1A3/COL17A1/COL9A1/MMP9/MYL9/ITGA3/TGFBI/ACTN2/SDC3/CLDN14/TRAF1/CLDN7/MAPK11/DSC3/CALB2/VAV2/RRAS
HALLMARK_ANGIOGENESIS HALLMARK_ANGIOGENESIS 32 0.582508829590457 1.3219150696626 0.105642834241744 0.33013385700545 0.284957644994178 2176 tags=38%, list=13%, signal=33% STC1/SLCO2A1/PGLYRP1/VTN/NRP1/LUM/VAV2/PRG2/VCAN/TIMP1/PDGFA/PF4
HALLMARK_GLYCOLYSIS HALLMARK_GLYCOLYSIS 193 0.413505087894996 1.19188332545375 0.121693794506612 0.350613838499161 0.302635102704539 1509 tags=11%, list=9%, signal=10% MET/STC1/GAL3ST1/TPBG/CHST1/GPC4/ARTN/HS6ST2/TKTL1/DCN/IGFBP3/LHX9/GPR87/SDC2/SDC1/TGFBI/SDC3/ANGPTL4/KDELR3/GPC3/P4HA2
HALLMARK_P53_PATHWAY HALLMARK_P53_PATHWAY 195 0.41138452824094 1.18768472118916 0.126220981859698 0.350613838499161 0.302635102704539 3517 tags=34%, list=21%, signal=27% EPHA2/ZNF365/CDKN1A/PHLDA3/NHLH2/TNFSF9/NUPR1/RRAD/KRT17/ZMAT3/RGS16/FDXR/TCHH/RPS27L/SDC1/ATF3/MDM2/TSPYL2/PLK2/TNNI1/AEN/DDB2/LIF/BAX/KLF4/POLH/HMOX1/SERTAD3/ABHD4/XPC/PDGFA/UPP1/GADD45A/SESN1/PLK3/PLXNB2/CDKN2B/HRAS/DDIT4/RNF19B/RALGDS/IFI30/DDIT3/NOTCH1/ZFP36L1/AK1/TRIAP1/RAD9A/PROCR/IER5/TAX1BP3/PTPRE/SAT1/MXD4/JUN/CD81/FOS/GLS2/DRAM1/JAG2/MXD1/BTG2/H2AJ/PPP1R15A/FGF13/MKNK2/S100A10
HALLMARK_PANCREAS_BETA_CELLS HALLMARK_PANCREAS_BETA_CELLS 28 0.568977468920356 1.26258589243534 0.160815402038505 0.423198426417119 0.365287062802145 645 tags=18%, list=4%, signal=17% ABCC8/GCK/SLC2A2/NEUROG3/HNF1A
HALLMARK_OXIDATIVE_PHOSPHORYLATION HALLMARK_OXIDATIVE_PHOSPHORYLATION 199 -0.335527955678041 -1.09737057858328 0.193122939236929 0.482807348092322 0.416738974142846 5343 tags=42%, list=32%, signal=29% VDAC2/PMPCA/VDAC1/CYB5R3/RETSAT/ATP5MG/GPI/IDH3B/ACADSB/NDUFB1/ATP6V1G1/NDUFB5/NDUFS2/PDHA1/HTRA2/FDX1/AFG3L2/ATP5PB/VDAC3/RHOT1/ISCA1/HADHB/HSPA9/CS/FXN/NDUFA6/ATP5MC3/FH/NDUFA9/MTX2/SLC25A5/TIMM9/IDH1/ATP5F1B/LRPPRC/DLD/OGDH/ACAA2/ATP5F1A/MRPL15/CYC1/SURF1/MDH1/ATP6V1C1/SLC25A3/OPA1/SLC25A20/MAOB/DLST/MRPS22/GOT2/COX15/ALDH6A1/ACADM/NDUFV2/CASP7/ATP6V1H/SDHB/ACAT1/SDHD/AIFM1/NDUFS1/NDUFA7/ABCB7/MTRR/BCKDHA/PDHB/SDHA/PRDX3/LDHA/PDP1/SUCLA2/GLUD1/OAT/NNT/MTRF1/CYCS/PDHX/TOMM70/NDUFA5/IDH3A/COX11/DLAT/ATP6V0C
HALLMARK_COAGULATION HALLMARK_COAGULATION 121 0.414968445456182 1.13948266939733 0.210092121545442 0.500219337012957 0.431768269842763 2358 tags=25%, list=14%, signal=21% KLKB1/CPB2/COMP/HPN/APOC2/CRIP2/CTSE/C1S/PLAT/PROC/LEFTY2/HTRA1/C8G/MMP9/LGMN/F2/TF/GDA/SERPINA1/LRP1/PRSS23/MMP11/THBS1/SERPINE1/TIMP1/PF4/ITGB3/F12/DPP4/CFD
HALLMARK_NOTCH_SIGNALING HALLMARK_NOTCH_SIGNALING 31 0.524476562923575 1.18501609638977 0.231646586345382 0.526469514421322 0.454426317711036 2714 tags=32%, list=16%, signal=27% WNT5A/DTX1/NOTCH3/DLL1/CCND1/HEYL/DTX4/NOTCH1/DTX2/PSEN2
HALLMARK_XENOBIOTIC_METABOLISM HALLMARK_XENOBIOTIC_METABOLISM 183 0.379001622451181 1.08816799312345 0.275038520801233 0.597909827828767 0.516090588231146 1439 tags=12%, list=9%, signal=11% SLC6A12/EPHA2/ATOH8/HSD17B2/ALDH3A1/FMO3/HGFAC/TDO2/FMO1/PTGDS/MPP2/DDC/ABCC2/SLC22A1/GNMT/CYP2C18/VTN/ABCC3/CYP27A1/AQP9/HSD11B1/IL1R1
HALLMARK_IL2_STAT5_SIGNALING HALLMARK_IL2_STAT5_SIGNALING 195 0.370114534243508 1.06853648407896 0.311429658759356 0.648811789081991 0.560027017944455 3070 tags=25%, list=19%, signal=20% GPR83/CXCL10/PTH1R/APLP1/PTCH1/CSF2/RGS16/SELP/BATF3/ICOS/IL10/SPRY4/NRP1/CCR4/TNFRSF9/ETV4/TRAF1/MYO1E/DRC1/NT5E/LIF/PLEC/IL10RA/COL6A1/CSF1/DHRS3/NCS1/FGL2/BHLHE40/CAPN3/IL18R1/PLPP1/KLF6/NFIL3/TNFRSF18/IL1R2/IL2RA/CKAP4/HIPK2/EMP1/PHLDA1/CDKN1C/PIM1/IL1RL1/PLIN2/TTC39B/CD81/F2RL2
HALLMARK_INTERFERON_ALPHA_RESPONSE HALLMARK_INTERFERON_ALPHA_RESPONSE 97 0.389471247581951 1.0422291104565 0.388116846284742 0.732915965273969 0.632622201604899 2658 tags=15%, list=16%, signal=13% CXCL11/CXCL10/C1S/IFIH1/IFI44L/CSF1/MX1/HERC6/GMPR/IL15/IFI30/IFI35/IRF9/PARP12/PROCR
HALLMARK_INTERFERON_GAMMA_RESPONSE HALLMARK_INTERFERON_GAMMA_RESPONSE 197 0.354092467848089 1.02312509106096 0.409206188181588 0.732915965273969 0.632622201604899 3310 tags=23%, list=20%, signal=18% CXCL11/CXCL10/CCL7/ZBP1/CDKN1A/C1S/SELP/CCL2/IFIH1/TNFAIP6/CMKLR1/CCL5/PTGS2/IFI44L/FPR1/IL10RA/SLAMF7/CD38/FGL2/MX1/TNFAIP3/KLRK1/UPP1/CD274/HERC6/IL15/IFI30/IFI35/CD69/IL18BP/IRF9/PARP12/MVP/P2RY14/FCGR1A/PIM1/TRIM21/NFKBIA/MT2A/HLA-DRB1/SOD2/PELI1/RNF213/IFI44/NCOA3
HALLMARK_UV_RESPONSE_UP HALLMARK_UV_RESPONSE_UP 152 0.362946863904234 1.02291276178369 0.410432940553422 0.732915965273969 0.632622201604899 4162 tags=32%, list=25%, signal=24% SLC6A12/SHOX2/OLFM1/FMO1/RRAD/MAPK8IP2/NR4A1/PLCL1/NTRK3/TCHH/ATF3/SLC6A8/C4BPB/PDLIM3/HMOX1/CHKA/CDKN2B/IGFBP2/GPX3/MMP14/CXCL2/NPTX2/E2F5/CDKN1C/DLG4/NFKBIA/NPTXR/MSX1/FOS/AGO2/SOD2/CLCN2/PRPF3/BTG2/ATP6V1F/SELENOW/TYRO3/RHOB/SQSTM1/SLC25A4/JUNB/YKT6/BSG/CCNE1/ABCB1/CDO1/FOSB/ARRB2
HALLMARK_HEME_METABOLISM HALLMARK_HEME_METABOLISM 193 -0.312548025365724 -1.01873771579925 0.37511693171188 0.732915965273969 0.632622201604899 2893 tags=22%, list=18%, signal=19% CPOX/SLC2A1/PPOX/LAMP2/GMPS/SLC10A3/ABCG2/KLF3/BNIP3L/GYPE/BTRC/CA1/HBQ1/BACH1/CLIC2/NNT/CAT/H4C3/SPTA1/AQP3/OSBP2/FBXO34/ERMAP/ARL2BP/TNS1/RAP1GAP/KEL/NEK7/SLC30A1/ASNS/C3/ANK1/RHAG/XK/KLF1/GYPB/ALAS2/SLC4A1/GYPA/HBB/TSPO2/EPB42/AHSP
HALLMARK_SPERMATOGENESIS HALLMARK_SPERMATOGENESIS 113 -0.325484940748912 -0.996277400691544 0.453959154424937 0.782688197284375 0.675583496603355 834 tags=12%, list=5%, signal=11% DDX4/PCSK4/TULP2/DDX25/CRISP2/GPR182/ART3/GAPDHS/CLVS1/PAPOLB/AKAP4/YBX2/SYCP1
HALLMARK_KRAS_SIGNALING_DN HALLMARK_KRAS_SIGNALING_DN 157 0.350148765762939 0.990112894139098 0.484840495649881 0.786116879264313 0.678542990522881 2149 tags=23%, list=13%, signal=20% TENM2/SYNPO/SHOX2/PDCD1/HSD11B2/IL12B/P2RX6/KLHDC8A/SOX10/EDN1/HNF1A/TG/FSHB/AKR1B10/SCGB1A1/MYO15A/CACNA1F/KCNQ2/TNNI3/NR4A2/RYR1/GPR19/TFCP2L1/ITIH3/CALCB/CPA2/EFHD1/IFI44L/CCNA1/ITGB1BP2/GPRC5C/MX1/CD40LG/PTPRJ/IDUA/SGK1
HALLMARK_TGF_BETA_SIGNALING HALLMARK_TGF_BETA_SIGNALING 54 -0.358860383314176 -0.974483252168879 0.487392465143874 0.786116879264313 0.678542990522881 1768 tags=13%, list=11%, signal=12% BCAR3/TGFB1/SMAD6/BMPR1A/TJP1/BMP2/CDH1
HALLMARK_G2M_CHECKPOINT HALLMARK_G2M_CHECKPOINT 198 -0.296410072039874 -0.968270939705052 0.558018867924528 0.871904481132075 0.752591236345581 5350 tags=43%, list=32%, signal=30% DKC1/KATNA1/SLC12A2/HMGB3/NOLC1/SLC7A5/RBL1/MAP3K20/E2F4/STAG1/PRPF4B/KPNA2/KPNB1/RACGAP1/KIF11/STIL/TOP2A/BARD1/HMMR/SMC2/PLK1/NUP50/TPX2/POLQ/SS18/EWSR1/PAFAH1B1/CHAF1A/RBM14/MEIS1/CHEK1/SRSF10/CDK4/SLC7A1/CKS2/CDC6/AMD1/KIF15/CDC25B/CDKN2C/TFDP1/KIF2C/RPA2/RAD21/SMC1A/CKS1B/CDC20/DR1/PRMT5/TTK/SMAD3/SMC4/CCNB2/CDC45/PDS5B/SRSF1/KIF4A/CDKN3/MCM2/SRSF2/GSPT1/MCM3/ODC1/FBXO5/BUB3/MCM6/MAD2L1/SQLE/PLK4/KNL1/DBF4/CDC7/TMPO/MYC/LBR/BUB1/UBE2S/ORC5/CDK1/TGFB1/NEK2/EXO1/AURKA/CCNA2/PBK/CENPA
HALLMARK_ESTROGEN_RESPONSE_LATE HALLMARK_ESTROGEN_RESPONSE_LATE 186 0.327905826851339 0.94157679853208 0.60990990990991 0.924105924105924 0.797649323965113 2159 tags=17%, list=13%, signal=15% CPE/HR/TPBG/OLFM1/ST6GALNAC2/CYP26B1/FOXC1/LARGE1/KLK10/ASS1/NMU/MYOF/CCN5/WFS1/LTF/PKP3/SLC24A3/S100A9/SEMA3B/DLG5/CCND1/MAPT/SERPINA1/PDLIM3/PRSS23/KLF4/EGR3/CCNA1/PLAC1/TNNC1/SGK1/RPS6KA2
HALLMARK_COMPLEMENT HALLMARK_COMPLEMENT 192 0.32211497807598 0.927903364172501 0.641309887869521 0.943102776278707 0.8140466068932 2996 tags=26%, list=18%, signal=21% KLKB1/GZMB/C1S/PLAT/MMP12/F5/PLA2G7/LTF/S100A12/C1QC/S100A9/PCLO/ACTN2/LGMN/PHEX/CR1/CPM/DOCK4/CTSL/DUSP5/F2/CCL5/C4BPB/CP/ADRA2B/SERPINA1/LRP1/FCN1/KCNIP3/SERPINE1/CD40LG/TNFAIP3/TIMP1/CXCL1/DPP4/LGALS3/HSPA1A/GP9/MMP14/TFPI2/PIM1/PLAUR/CR2/KYNU/SIRT6/C1QA/ME1/DGKH/CTSH
HALLMARK_UV_RESPONSE_DN HALLMARK_UV_RESPONSE_DN 139 0.320288926120842 0.894946834252622 0.701189362555125 0.98430067911248 0.849606901970772 2281 tags=15%, list=14%, signal=13% MT1E/MET/COL1A1/PLPP3/HAS2/KCNMA1/SDC2/SCHIP1/NRP1/COL1A2/EFEMP1/CAP2/SCN8A/VAV2/SERPINE1/DLC1/BHLHE40/CCN1/ITGB3/TGFBR3/SLC22A18
HALLMARK_ESTROGEN_RESPONSE_EARLY HALLMARK_ESTROGEN_RESPONSE_EARLY 189 0.31069440364981 0.89358127018612 0.725630844114256 0.98430067911248 0.849606901970772 2159 tags=17%, list=13%, signal=15% HR/TPBG/MLPH/OLFM1/GFRA1/CYP26B1/FOXC1/KLK10/RAB17/TBC1D30/MYOF/CCN5/WFS1/REEP1/SLC24A3/SEMA3B/ADCY9/ZNF185/CLDN7/CCND1/RHOD/MSMB/MAPT/CALB2/PDLIM3/PRSS23/KLF4/EGR3/DHRS3/DLC1/BHLHE40/CBFA2T3/RPS6KA2
HALLMARK_ALLOGRAFT_REJECTION HALLMARK_ALLOGRAFT_REJECTION 193 0.309782276632993 0.892913632380078 0.728382502543235 0.98430067911248 0.849606901970772 2458 tags=18%, list=15%, signal=16% IL12B/CCL7/SIT1/GZMB/CCL22/ACHE/IL11/CCL19/ICOSLG/CXCL13/CCL2/CCL4/CD8A/MMP9/IL4/IL10/INHBA/TLR3/F2/CCL5/LIF/IGSF6/CCL13/CSF1/BCL3/CD40LG/RPS19/CD7/TIMP1/PF4/IL18RAP/NLRP3/IL15/CCR5/IL2RA
HALLMARK_PROTEIN_SECRETION HALLMARK_PROTEIN_SECRETION 94 -0.293529934190925 -0.877877475317017 0.760026963262555 1 0.863157894736842 4557 tags=30%, list=28%, signal=22% VPS4B/OCRL/SEC22B/PAM/AP3S1/PPT1/TMED10/ZW10/USO1/RAB2A/CTSC/RAB22A/ARFIP1/RAB14/ATP6V1H/TPD52/GALC/LAMP2/SCAMP1/ANP32E/BET1/VAMP4/TMX1/RAB9A/TOM1L1/EGFR/SSPN/SH3GL2
HALLMARK_ANDROGEN_RESPONSE HALLMARK_ANDROGEN_RESPONSE 97 -0.271495241419729 -0.815023171733586 0.894915254237288 1 0.863157894736842 3547 tags=33%, list=22%, signal=26% SPCS3/CENPN/ELL2/TNFAIP8/H1-0/MAK/MERTK/TPD52/GPD1L/DNAJB9/RAB4A/FKBP5/HMGCR/HERC3/INSIG1/UBE2J1/GNAI3/SORD/KRT8/ZBTB10/ELOVL5/IDI1/SELENOP/SCD/NKX3-1/HMGCS1/BMPR1B/ALDH1A3/STEAP4/PTPN21/ADAMTS1/LIFR
HALLMARK_MITOTIC_SPINDLE HALLMARK_MITOTIC_SPINDLE 199 0.2818164922138 0.81461747440462 0.901002665312857 1 0.863157894736842 4341 tags=21%, list=26%, signal=15% SYNPO/SHROOM2/SORBS2/ARHGAP29/CDC42EP2/DOCK4/MYO1E/CTTN/CEP72/CSNK1D/BCR/PLEKHG2/OPHN1/CLASP1/ABR/ARL8A/GSN/SSH2/CLIP1/FGD4/NEDD9/CEP131/TUBGCP6/AKAP13/CDK5RAP2/KLC1/ARAP3/KATNB1/KIF1B/KIF3B/MARK4/PREX1/RAPGEF5/CEP250/ATG4B/CNTROB/ESPL1/BCL2L11/MYO9B/DYNLL2/ARHGEF2
HALLMARK_BILE_ACID_METABOLISM HALLMARK_BILE_ACID_METABOLISM 102 0.300398766331911 0.809263274593015 0.849284310973898 1 0.863157894736842 1463 tags=13%, list=9%, signal=12% ABCA4/AKR1D1/TTR/PIPOX/ABCA6/AGXT/EPHX2/GNMT/FDXR/CYP27A1/AQP9/TFCP2L1/NR3C2
HALLMARK_CHOLESTEROL_HOMEOSTASIS HALLMARK_CHOLESTEROL_HOMEOSTASIS 72 -0.280348464746524 -0.800425780679533 0.88828598787105 1 0.863157894736842 2876 tags=32%, list=17%, signal=26% SC5D/JAG1/HMGCR/LPL/DHCR7/CYP51A1/SQLE/IDI1/ALDOC/ACAT2/TRIB3/TMEM97/PNRC1/STARD4/SCD/FASN/HSD17B7/MVK/HMGCS1/PCYT2/PPARG/CBS/ADH4
HALLMARK_APICAL_SURFACE HALLMARK_APICAL_SURFACE 40 0.335142271686118 0.788120882543766 0.813157481551264 1 0.863157894736842 818 tags=10%, list=5%, signal=10% SHROOM2/MDGA1/EFNA5/SLC34A3
HALLMARK_ADIPOGENESIS HALLMARK_ADIPOGENESIS 195 0.24364715815744 0.703419762386564 0.993657237092477 1 0.863157894736842 1450 tags=5%, list=9%, signal=5% LAMA4/SPARCL1/MRAP/ADIG/FABP4/SOWAHC/EPHX2/LEP/MTARC2/ANGPTL4
HALLMARK_PI3K_AKT_MTOR_SIGNALING HALLMARK_PI3K_AKT_MTOR_SIGNALING 102 0.260609509778496 0.702072474693188 0.972635419590233 1 0.863157894736842 539 tags=3%, list=3%, signal=3% FGF6/FGF17/CDKN1A
HALLMARK_FATTY_ACID_METABOLISM HALLMARK_FATTY_ACID_METABOLISM 147 0.240659018046067 0.676410787885302 0.994428969359331 1 0.863157894736842 721 tags=4%, list=4%, signal=4% RDH16/AQP7/ALDH3A1/TDO2/IL4I1/FMO1
HALLMARK_MTORC1_SIGNALING HALLMARK_MTORC1_SIGNALING 200 -0.197067780125509 -0.644691376663296 1 1 0.863157894736842 5745 tags=50%, list=35%, signal=33% GBE1/EIF2S2/WARS1/NAMPT/RPN1/RPA1/PSMC2/DHCR24/PLOD2/FADS2/DHFR/ALDOA/PSME3/PDK1/CANX/SLC7A5/HK2/TFRC/HSPA9/NUFIP1/MCM4/PSMG1/FADS1/NUP205/GTF2H1/SRD5A1/EPRS1/PLK1/PSMA3/ERO1A/TES/GOT1/PSMD14/GAPDH/IDH1/GCLC/SLC1A5/IFRD1/PNO1/P4HA1/TUBA4A/MTHFD2/PSPH/HSPA4/UCHL5/PGM1/ADD3/UBE2D3/TCEA1/USO1/LTA4H/TBK1/RRM2/PGK1/COPS5/CTSC/CCNG1/HMBS/SKAP2/AK4/ACLY/HPRT1/UNG/ACTR3/ELOVL6/TUBG1/UFM1/CACYBP/SC5D/SLC2A1/GMPS/MCM2/SLC37A4/HMGCR/PITPNB/POLR3G/LDHA/INSIG1/SORD/DHCR7/CALR/ELOVL5/CYP51A1/SQLE/TOMM40/IDI1/PPA1/TRIB3/BUB1/TMEM97/EEF1E1/STARD4/SCD/PSAT1/VLDLR/IGFBP5/AURKA/XBP1/HMGCS1/ASNS
HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY 49 -0.23352168703473 -0.622529725951665 0.989099254159495 1 0.863157894736842 245 tags=6%, list=1%, signal=6% CAT/MPO/SRXN1
HALLMARK_UNFOLDED_PROTEIN_RESPONSE HALLMARK_UNFOLDED_PROTEIN_RESPONSE 111 0.146974681775487 0.400780870358483 1 1 0.863157894736842 1464 tags=5%, list=9%, signal=4% WFS1/CCL2/ATF3/KDELR3/TSPYL2
HALLMARK_DNA_REPAIR HALLMARK_DNA_REPAIR 147 0.138687736946615 0.389804139399141 1 1 0.863157894736842 5565 tags=31%, list=34%, signal=20% CCNO/DDB2/POLH/XPC/NME3/AK1/NT5C/ZNF707/ALYREF/DAD1/VPS37B/GUK1/TAF13/MPG/GTF2H5/BCAP31/CETN2/DGCR8/ADCY6/PDE4B/EDF1/NELFB/SDCBP/BRF2/SUPT5H/REV3L/POLD4/SUPT4H1/VPS28/DGUOK/GTF2F1/EIF1B/ITPA/NPR2/ADA/GPX4/GTF3C5/ERCC1/POLA2/POM121/RBX1/PDE6G/POLB/USP11/ADRM1
unstrand_96h/GE_96h-RNP_NEG_96h-gsea-sasp.txt
0 → 100755
View file @
f9b173e7
ID Description setSize enrichmentScore NES pvalue p.adjust qvalue rank leading_edge core_enrichment
SASP_SCHLEICH SASP_SCHLEICH 71 0.394950804381887 1.01733364014199 0.435280305253889 0.508955460453321 0.508955460453321 2847 tags=32%, list=17%, signal=27% CPE/KITLG/IGFBP3/CCL1/PLAT/CXCL13/MMP12/CSF2/CCL2/FGF7/CXCR2/CXCL5/MIF/SERPINE1/BHLHE40/TIMP1/CXCL1/IL15/IGFBP2/MMP14/CXCL2/PLAUR/IGFBP6
CLASSICAL_SASP CLASSICAL_SASP 33 0.427496748900269 0.974632504740691 0.508955460453321 0.508955460453321 0.508955460453321 2418 tags=45%, list=15%, signal=39% BGN/COL1A1/KITLG/DCN/CCL2/FGF7/MMP9/CXCL8/EFEMP1/CSF1/THBS1/SERPINE1/CXCL1/IL15/IGFBP2
unstrand_96h/GE_96h-RNP_NEG_96h-gsea-senescence_signatures.txt
0 → 100755
View file @
f9b173e7
ID Description setSize enrichmentScore NES pvalue p.adjust qvalue rank leading_edge core_enrichment
SenMayo SenMayo 107 0.505343755028366 1.37496550258688 0.0314063368538077 0.219844357976654 0.198355811708259 2418 tags=33%, list=15%, signal=28% CXCL10/CCL7/GDF15/KITLG/CCL8/EDN1/SEMA3F/IGFBP3/CCL1/PLAT/MMP12/VGF/CSF2/NRG1/CCL2/CXCL3/CCL4/FGF7/MMP9/CXCR2/CXCL8/PAPPA/IL10/CCL3/CXCL16/ANGPTL4/CCL5/CCL13/CSF1/MIF/CCL24/CXCL1/IL15/TNFRSF10C/IGFBP2
Casella Casella 48 -0.492712847506711 -1.32118125354135 0.0803493449781659 0.281222707423581 0.253734773615261 2847 tags=21%, list=17%, signal=17% SLC16A14/ITPRIPL1/MCUB/CDCA7L/LBR/SRPX/CBS/PTCHD4/SMCO3/CLDN1
Pribluda_SENESCENCE_INFLAMMATORY_GENES Pribluda_SENESCENCE_INFLAMMATORY_GENES 93 0.447835582507035 1.19807168959843 0.161725067385445 0.377358490566038 0.34047382607462 2308 tags=26%, list=14%, signal=22% CPE/CXCL10/HIF3A/CCDC33/CDKN1A/IGFBP3/CSF2/CXCL3/NXN/TNFRSF10B/CCL3/MAPK11/CPA2/CXCL5/FAIM2/IL1RN/MIF/SERPINE1/MX1/BHLHE40/CXCL1/CD14/CDKN2B/IL15
Sencan Sencan 29 0.481534215761095 1.07206508810001 0.37084811351177 0.648984198645598 0.585549652913322 1590 tags=52%, list=10%, signal=47% CXCL11/CXCL10/PSG6/EBI3/MMP12/CSF2/IGFL2/TREM2/CD163/CILP/CCL3/COL10A1/TAC3/PPBP/LUM
Purcell Purcell 45 0.348579207871644 0.836155256094739 0.742133537989256 0.890279114533205 0.803259351458531 2672 tags=29%, list=16%, signal=24% CD163L1/MMP12/COL17A1/ATF3/TNFAIP6/BIRC3/IL1RN/TNFAIP3/ITGB3/GMPR/IFI30/CXCL2/HERC5
Hernandez Hernandez 53 -0.304290494595374 -0.831426085443073 0.800235017626322 0.890279114533205 0.803259351458531 3464 tags=30%, list=21%, signal=24% NFIA/POFUT2/ASCC1/RHNO1/PDS5B/DYNLT3/UFM1/USP6NL/BCL2L2/SLC10A3/SMO/SPIN4/NOL3/TSPAN13/SCOC/EFNB3
FRIDMAN_SENESCENCE_UP FRIDMAN_SENESCENCE_UP 75 -0.275456522114041 -0.799498577068867 0.890279114533205 0.890279114533205 0.803259351458531 2061 tags=15%, list=13%, signal=13% CLTB/F3/TFAP2A/IGFBP5/ING1/ALDH1A3/CITED2/CXCL14/MMP1/CRYAB/IFNG
unstrand_96h/GE_ANAK_96h-GE_96h-gsea-h.all.v7.2.symbols.txt
0 → 100755
View file @
f9b173e7
ID Description setSize enrichmentScore NES pvalue p.adjust qvalues rank leading_edge core_enrichment
HALLMARK_KRAS_SIGNALING_UP HALLMARK_KRAS_SIGNALING_UP 181 -0.553035244644055 -1.59962977187136 0.000785175879396985 0.0392587939698492 0.0380190425813277 2194 tags=24%, list=13%, signal=21% ACE/CLEC4A/H2BC3/BPGM/SCG3/IL10RA/GUCY1A1/BIRC3/TNFAIP3/TRAF1/ADGRL4/CIDEA/ETV1/GADD45G/CBX8/ABCB1/APOD/ALDH1A3/F2RL1/SCG5/CFB/KIF5C/PIGR/CSF2/HSD11B1/BTC/PDCD1LG2/NR0B2/ANGPTL4/ALDH1A2/SPARCL1/PEG3/ANXA10/SEMA3B/MALL/CCL20/IGFBP3/CPE/GPRC5B/SLPI/PTPRR/GABRA3/SNAP25
HALLMARK_PANCREAS_BETA_CELLS HALLMARK_PANCREAS_BETA_CELLS 28 -0.716000450591474 -1.57177860201049 0.00988319856244385 0.21243115656963 0.205722804256905 613 tags=25%, list=4%, signal=24% HNF1A/PAX6/CHGA/SLC2A2/PKLR/GCK/ABCC8
HALLMARK_ESTROGEN_RESPONSE_LATE HALLMARK_ESTROGEN_RESPONSE_LATE 186 -0.479274843970143 -1.38961210536516 0.0127458693941778 0.21243115656963 0.205722804256905 1277 tags=13%, list=8%, signal=13% DLG5/UNC13B/OPN3/LTF/WFS1/PKP3/ASS1/PDLIM3/RET/KLK10/PRSS23/SEMA3B/CYP26B1/TJP3/CPE/FOXC1/CDH1/OLFM1/TPBG/ST6GALNAC2/PTGES/TFPI2/CA12/HR/PLAC1
HALLMARK_HYPOXIA HALLMARK_HYPOXIA 192 -0.457153848392446 -1.32848255507196 0.024251968503937 0.303149606299213 0.293576460837132 1595 tags=15%, list=10%, signal=14% F3/LDHC/SRPX/BGN/MIF/GPC3/EFNA3/SELENBP1/KIF5A/TGM2/CP/PPFIA4/TGFB3/P4HA2/ALDOB/LOX/ANGPTL4/DCN/MT1E/LALBA/IGFBP3/PKLR/TPBG/CHST3/GCK/PPP1R3C/CA12/STC1/PPARGC1A
HALLMARK_APICAL_SURFACE HALLMARK_APICAL_SURFACE 40 -0.597073969131314 -1.40327765178555 0.0553910468559484 0.553910468559484 0.536418559026027 1837 tags=28%, list=11%, signal=24% IL2RB/SLC2A4/MDGA1/SRPX/THY1/NTNG1/SCUBE1/SLC34A3/MAL/PCSK9/SHROOM2
HALLMARK_APICAL_JUNCTION HALLMARK_APICAL_JUNCTION 182 -0.420805851977471 -1.21808802188929 0.0864584967833046 0.720487473194205 0.697735237198598 2739 tags=25%, list=17%, signal=21% BMP1/FSCN1/JUP/MAPK11/TMEM8B/NRXN2/CD276/CERCAM/CLDN15/CD86/ADAM15/ACTN2/VWF/VAV2/PLCG1/TRO/ITGA3/TRAF1/IKBKG/DSC3/WNK4/MMP2/COL9A1/LAMB3/ATP1A3/THY1/IRS1/SLC30A3/LAYN/CLDN5/CADM2/CLDN6/PPP2R2C/CRB3/COL17A1/ADAM23/CD209/AMH/ACTA1/CDH1/NECTIN3/SHROOM2/CDH4/CADM3/PDZD3/NFASC
HALLMARK_KRAS_SIGNALING_DN HALLMARK_KRAS_SIGNALING_DN 157 0.385320264491414 1.15329503867489 0.141730141458107 0.741370928536704 0.717959215003966 1437 tags=18%, list=9%, signal=17% MEFV/SCN10A/RYR2/PROP1/WNT16/CAPN9/TGM1/CPA2/IFNG/ZNF112/CYP39A1/IL5/THNSL2/LGALS7/RGS11/EFHD1/TSHB/THRB/SERPINB2/CACNA1F/FGFR3/UPK3B/CDH16/YBX2/CELSR2/CCR8/COL2A1/SCGB1A1/GPR3
HALLMARK_GLYCOLYSIS HALLMARK_GLYCOLYSIS 193 -0.398996360394502 -1.15983601468533 0.143958464443046 0.741370928536704 0.717959215003966 2354 tags=17%, list=14%, signal=14% QSOX1/PAXIP1/G6PD/CAPN5/ABCB6/CITED2/DSC2/CHPF2/ARTN/SLC25A10/IDUA/LDHC/MIF/GPC3/EFNA3/PKP2/HS6ST2/PPFIA4/CLDN3/NOL3/P4HA2/ALDOB/LHX9/ANGPTL4/DCN/MET/IGFBP3/CHST1/TPBG/CHST4/GAL3ST1/STC1
HALLMARK_ANGIOGENESIS HALLMARK_ANGIOGENESIS 32 -0.562921720112531 -1.26906192736674 0.144778761061947 0.741370928536704 0.717959215003966 1230 tags=22%, list=7%, signal=20% VTN/OLR1/LPL/PGLYRP1/SLCO2A1/MSX1/STC1
HALLMARK_COAGULATION HALLMARK_COAGULATION 121 -0.427714059594399 -1.18159220546429 0.148274185707341 0.741370928536704 0.717959215003966 2181 tags=22%, list=13%, signal=20% VWF/MASP2/CAPN5/FN1/SH2B2/F12/GDA/F3/MMP2/HPN/PROC/CPB2/C8G/PROZ/COMP/CFB/OLR1/LEFTY2/HNF4A/CTSE/PRSS23/F10/APOC2/TMPRSS6/TFPI2/MMP1/KLKB1
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION 179 -0.376824268294844 -1.08946874811656 0.255092447508618 1 0.968421052631579 2484 tags=26%, list=15%, signal=23% ELN/CDH2/FBLN5/PTX3/QSOX1/FSTL1/FSTL3/FN1/ECM1/PDGFRB/COL4A1/TNFAIP3/FZD8/SERPINH1/ADAM12/CTHRC1/CAP2/MMP2/PCOLCE2/NNMT/DPYSL3/BGN/CRLF1/IL15/THY1/TGM2/THBS2/CXCL1/TGFBR3/COMP/MATN3/SPOCK1/LOX/LAMA1/EDIL3/PDLIM4/MAGEE1/DCN/SLIT3/IGFBP3/MSX1/COL1A1/TFPI2/MMP1/GREM1/COL12A1/CADM1
HALLMARK_ESTROGEN_RESPONSE_EARLY HALLMARK_ESTROGEN_RESPONSE_EARLY 189 -0.373786949318226 -1.08459858439755 0.260299921073402 1 0.968421052631579 1194 tags=10%, list=7%, signal=9% TGM2/OPN3/ZNF185/WFS1/PDLIM3/RET/KLK10/REEP1/PRSS23/SEMA3B/CYP26B1/TJP3/FOXC1/OLFM1/TPBG/PTGES/CA12/RAB17/HR
HALLMARK_PEROXISOME HALLMARK_PEROXISOME 99 -0.404861009308744 -1.08955732175773 0.290237029670148 1 0.968421052631579 1561 tags=7%, list=9%, signal=6% EHHADH/EPHX2/ABCB1/CEL/HSD11B2/ABCC8/CADM1
HALLMARK_HEDGEHOG_SIGNALING HALLMARK_HEDGEHOG_SIGNALING 32 -0.493713427532811 -1.11303737540342 0.308318584070796 1 0.968421052631579 1769 tags=22%, list=11%, signal=20% NRCAM/GLI1/THY1/RTN1/L1CAM/PTCH1/HEY1
HALLMARK_ANDROGEN_RESPONSE HALLMARK_ANDROGEN_RESPONSE 97 -0.397056034956095 -1.06476601281742 0.330068072389175 1 0.968421052631579 1301 tags=20%, list=8%, signal=18% PTPN21/ACTN1/PMEPA1/AKAP12/SORD/ARID5B/SGK1/PGM3/ABCC4/RRP12/CCND3/CDC14B/GUCY1A1/ADAMTS1/ALDH1A3/STEAP4/BMPR1B/LIFR/SPDEF
HALLMARK_UV_RESPONSE_UP HALLMARK_UV_RESPONSE_UP 152 -0.365109424662666 -1.03569461142727 0.365849777211967 1 0.968421052631579 3863 tags=31%, list=23%, signal=24% SPR/SQSTM1/APOM/STARD3/CDC34/BTG2/DNAJB1/TCHH/BSG/SLC25A4/GAL/MGAT1/EPCAM/ICAM1/CHRNA5/AQP3/FKBP4/ALDOA/TUBA4A/PLCL1/PTPRD/STK25/TYRO3/KLHDC3/EPHX1/GPX3/CYB5R1/MARK2/TAP1/CCND3/ACAA1/MRPL23/RRAD/CDKN2B/CLCN2/NPTXR/BAK1/ABCB1/PDLIM3/SLC6A12/RET/FMO1/C4BPB/MSX1/OLFM1/SHOX2/NTRK3
HALLMARK_SPERMATOGENESIS HALLMARK_SPERMATOGENESIS 113 0.352955837175013 1.01894803756339 0.395283260702384 1 0.968421052631579 1431 tags=12%, list=9%, signal=11% DMRT1/SYCP1/GAPDHS/TKTL1/PAPOLB/ACTL7B/CFTR/OAZ3/YBX2/TEKT2/HSPA2/ZPBP/GSG1
HALLMARK_MYOGENESIS HALLMARK_MYOGENESIS 179 -0.352468040762448 -1.01905038350689 0.397837668442495 1 0.968421052631579 1144 tags=14%, list=7%, signal=13% CKM/HRC/APOD/PVALB/SH3BGR/PPFIA4/RYR1/SLN/CACNG1/MYH8/ANKRD2/KCNH1/MAPRE3/TCAP/SGCA/REEP1/MYOG/IGFBP3/ACTA1/COL1A1/SPDEF/PPP1R3C/ERBB3/GJA5/MYL3
HALLMARK_INFLAMMATORY_RESPONSE HALLMARK_INFLAMMATORY_RESPONSE 189 0.319047302637998 0.97887717891849 0.508317425688574 1 0.968421052631579 1332 tags=9%, list=8%, signal=8% MEFV/CSF3/PCDH7/IL6/SELE/VIP/HAS2/SLC7A2/CCL22/IL1A/SLAMF1/CCL17/LCK/ACVR2A/MSR1/SCN1B/HBEGF
HALLMARK_XENOBIOTIC_METABOLISM HALLMARK_XENOBIOTIC_METABOLISM 183 -0.330163017887348 -0.956131455990887 0.564098540718657 1 0.968421052631579 2128 tags=15%, list=13%, signal=13% SERTAD1/PTGDS/ESR1/ABCC3/POR/ADH1C/ABCC2/ATOH8/UPB1/VTN/EPHA2/MPP2/CYP2J2/PDK4/CFB/HSD11B1/TAT/HNF4A/ENPEP/CYP2C18/SLC6A12/FMO1/HSD17B2/ALDH3A1/F10/XDH/TDO2/PTGES
HALLMARK_MITOTIC_SPINDLE HALLMARK_MITOTIC_SPINDLE 199 -0.320346420336076 -0.934745046386091 0.628205128205128 1 0.968421052631579 5869 tags=39%, list=36%, signal=26% AURKA/PCGF5/GEMIN4/SPTAN1/FARP1/SPTBN1/BCR/NUMA1/CSNK1D/MARK4/INCENP/ARFIP2/CEP250/ARHGAP27/RHOT2/CEP192/KIF1B/TTK/SEPTIN9/BCL2L11/KIF20B/CAPZB/VCL/SMC1A/RACGAP1/ALMS1/TRIO/NET1/EPB41/DOCK2/FBXO5/KIF3B/PREX1/ARHGAP10/CEP72/LLGL1/ACTN4/OPHN1/PALLD/KIF11/GSN/PIF1/ARHGAP4/KIF22/SUN2/KLC1/ARHGEF2/MYH9/DLGAP5/ITSN1/NUSAP1/MID1IP1/ATG4B/TBCD/LMNB1/ABR/TUBA4A/RHOF/KIF23/SAC3D1/ARHGDIA/CEP131/PLEKHG2/MYO1E/NOTCH2/FSCN1/FLNA/ESPL1/PLK1/SYNPO/TUBGCP6/CLASP1/KATNB1/MAP1S/KIF3C/ARHGAP29/ARAP3/SHROOM2
HALLMARK_IL6_JAK_STAT3_SIGNALING HALLMARK_IL6_JAK_STAT3_SIGNALING 80 -0.335855790753927 -0.878329799906837 0.712367846954187 1 0.968421052631579 3234 tags=20%, list=20%, signal=16% CXCL10/PIM1/CXCL3/MYD88/CXCL13/IRF9/EBI3/CXCL11/CSF1/IL12RB1/SOCS1/BAK1/CXCL1/CSF2/INHBE/CCL7
HALLMARK_BILE_ACID_METABOLISM HALLMARK_BILE_ACID_METABOLISM 102 0.302077624422449 0.859481219356783 0.803698074974671 1 0.968421052631579 1529 tags=10%, list=9%, signal=9% HAO1/DIO2/CYP39A1/BMP6/ABCA9/ABCD2/TTR/LCK/BCAR3/ABCA1
HALLMARK_CHOLESTEROL_HOMEOSTASIS HALLMARK_CHOLESTEROL_HOMEOSTASIS 72 -0.317720133714649 -0.819910433805608 0.819658264253087 1 0.968421052631579 1089 tags=6%, list=7%, signal=5% GPX8/LPL/SEMA3B/AVPR1A
HALLMARK_COMPLEMENT HALLMARK_COMPLEMENT 192 0.287773244843694 0.884236406591113 0.82092004381161 1 0.968421052631579 2325 tags=18%, list=14%, signal=15% F7/IL6/COL4A2/HPCAL4/C9/C3/MMP12/DOCK9/SERPINB2/C1R/L3MBTL4/SERPINC1/CDA/LCK/GNGT2/C1QA/F2/ANG/NOTCH4/S100A13/CASP5/C1QC/GATA3/CTSV/CDK5R1/KYNU/MMP15/DOCK4/RASGRP1/SERPINA1/F5/CASP9/RABIF/FYN
HALLMARK_ALLOGRAFT_REJECTION HALLMARK_ALLOGRAFT_REJECTION 193 0.287645953792564 0.883932059211572 0.823916620954471 1 0.968421052631579 1242 tags=8%, list=8%, signal=7% IL13/CD8B/IL6/IFNG/CD247/CRTAM/INHBB/CCL22/CD1D/IL4/LCK/IRF4/ACVR2A/F2/IL12A
HALLMARK_WNT_BETA_CATENIN_SIGNALING HALLMARK_WNT_BETA_CATENIN_SIGNALING 40 -0.326389465245637 -0.767099331132805 0.851245427625849 1 0.968421052631579 545 tags=15%, list=3%, signal=15% FZD8/HDAC11/DKK4/PTCH1/HEY1/AXIN2
HALLMARK_INTERFERON_GAMMA_RESPONSE HALLMARK_INTERFERON_GAMMA_RESPONSE 197 -0.289055152642524 -0.84217016221777 0.878526645768025 1 0.968421052631579 3941 tags=26%, list=24%, signal=20% IFI44/STAT3/RBCK1/NLRC5/IFI35/PELI1/PTGS2/EIF4E3/ARID5B/CIITA/CASP7/FGL2/ICAM1/CXCL10/IRF5/ISG20/HELZ2/PIM1/NOD1/GPR18/IFNAR2/MYD88/IRF2/IRF9/XAF1/TAP1/CMTR1/BANK1/CD86/LGALS3BP/CDKN1A/IL2RB/CXCL11/BPGM/IL10RA/IFIH1/TNFAIP3/HERC6/XCL1/SOCS1/OGFR/CMPK2/OASL/BATF2/IL15/SELP/IDO1/CFB/GBP6/ITGB7/CCL7/ZBP1
HALLMARK_INTERFERON_ALPHA_RESPONSE HALLMARK_INTERFERON_ALPHA_RESPONSE 97 -0.298728119975664 -0.801084787083269 0.880624273617798 1 0.968421052631579 5038 tags=34%, list=31%, signal=24% PARP9/IFI27/DHX58/SAMD9/LPAR6/SLC25A28/HLA-C/TMEM140/UBA7/PROCR/IFI44/MVB12A/IFI35/CXCL10/ISG20/HELZ2/MOV10/IRF2/IRF9/TAP1/CMTR1/CCRL2/LGALS3BP/CXCL11/IFIH1/CSF1/HERC6/OGFR/CMPK2/OASL/BATF2/IL15/LAMP3
HALLMARK_MYC_TARGETS_V2 HALLMARK_MYC_TARGETS_V2 57 -0.309617390448841 -0.77097291560318 0.8808911739503 1 0.968421052631579 6303 tags=46%, list=38%, signal=28% NOP56/UNG/MPHOSPH10/LAS1L/MCM4/MYC/CDK4/SUPV3L1/MCM5/GRWD1/NOP2/TCOF1/PES1/PLK4/SLC19A1/SORD/TFB2M/TBRG4/IPO4/MYBBP1A/RRP12/BYSL/MAP3K6/DUSP2/PLK1/NOC4L
HALLMARK_IL2_STAT5_SIGNALING HALLMARK_IL2_STAT5_SIGNALING 195 -0.287770417817578 -0.83749939342071 0.887527489789507 1 0.968421052631579 3497 tags=21%, list=21%, signal=16% CYFIP1/ENO3/SLC1A5/GADD45B/FGL2/SYNGR2/GATA1/LIF/CXCL10/BHLHE40/PIM1/RGS16/ETFBKMT/MYO1E/CTSZ/ST3GAL4/CD86/CCND3/CISH/IL2RB/COCH/ECM1/IL10RA/TNFRSF18/CSF1/TRAF1/CAPN3/MUC1/SOCS1/SELP/ABCB1/MAP6/TGM2/CSF2/CCR4/EOMES/TNFSF11/PTCH1/GPR83/ICOS
HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY 49 -0.307274085863937 -0.745261627759478 0.898886181691612 1 0.968421052631579 5554 tags=41%, list=34%, signal=27% CAT/SBNO2/NQO1/PRDX1/IPCEF1/ABCC1/HHEX/SCAF4/PTPA/LSP1/PRNP/MGST1/EGLN2/OXSR1/STK25/ERCC2/FES/GPX3/G6PD/SRXN1
HALLMARK_TGF_BETA_SIGNALING HALLMARK_TGF_BETA_SIGNALING 54 0.28593411180021 0.740679380067895 0.929130125622185 1 0.968421052631579 2500 tags=20%, list=15%, signal=17% TJP1/WWTR1/SMAD6/BCAR3/CDKN1C/NOG/SMAD3/ACVR1/SMURF2/XIAP/SERPINE1
HALLMARK_TNFA_SIGNALING_VIA_NFKB HALLMARK_TNFA_SIGNALING_VIA_NFKB 199 -0.277251616643179 -0.808997881068444 0.942620387742339 1 0.968421052631579 3342 tags=22%, list=20%, signal=18% SGK1/ICAM1/PLAU/LIF/CXCL10/BHLHE40/GEM/RELA/CXCL3/BIRC2/KDM6B/NR4A3/SPSB1/DUSP5/PER1/TAP1/DUSP2/ZFP36/CCRL2/CDKN1A/PTX3/SLC2A6/BCL6/PTGER4/CXCL11/EDN1/IFIH1/BIRC3/CSF1/TNFAIP3/TRAF1/CLCF1/F3/TNFSF9/SLC16A6/LAMB3/F2RL1/CXCL1/CSF2/OLR1/ICOSLG/MSC/CCL20/IL12B
HALLMARK_NOTCH_SIGNALING HALLMARK_NOTCH_SIGNALING 31 -0.28506570342608 -0.638383415582819 0.956049822064057 1 0.968421052631579 3776 tags=48%, list=23%, signal=37% DTX1/PSENEN/ARRB1/DTX4/LFNG/APH1A/NOTCH1/PPARD/NOTCH2/MAML2/FZD1/DTX2/NOTCH3/FZD5/HEYL
HALLMARK_APOPTOSIS HALLMARK_APOPTOSIS 161 -0.267383176678115 -0.763360053307377 0.974261803252803 1 0.968421052631579 2009 tags=16%, list=12%, signal=14% FEZ1/GADD45B/CASP7/NEFH/FDXR/ISG20/RARA/DAP/RELA/AIFM3/GPX3/TAP1/PPP3R1/CDKN1A/RNASEL/PDGFRB/BIRC3/MMP2/BGN/PRF1/TGFBR3/DCN/PLPPR4/AVPR1A/ERBB3
HALLMARK_UV_RESPONSE_DN HALLMARK_UV_RESPONSE_DN 139 0.259927271460193 0.768140007723634 0.97561622051418 1 0.968421052631579 1537 tags=9%, list=9%, signal=9% HAS2/PPARG/RND3/BDNF/TJP1/CDON/EFEMP1/COL3A1/IGFBP5/CAV1/ACVR2A/VLDLR/SDC2
HALLMARK_OXIDATIVE_PHOSPHORYLATION HALLMARK_OXIDATIVE_PHOSPHORYLATION 199 0.258352026083371 0.797195715413557 0.977537437603993 1 0.968421052631579 5681 tags=43%, list=34%, signal=29% ATP5ME/UQCR10/NDUFB1/COX17/MTRF1/POLR2F/AIFM1/COX5B/ATP5F1E/ATP5MC1/ATP5PF/NDUFB2/TIMM8B/NDUFS6/NDUFAB1/UQCRQ/NDUFC1/COX6B1/COX6A1/ATP5MF/NDUFA6/NDUFA3/NDUFA1/COX8A/NDUFB6/COX7A2/ATP5PD/COX6C/UQCR11/NDUFB8/ATP6V1G1/COX7C/COX7B/MGST3/NDUFB5/TIMM10/ATP5MG/ISCU/NDUFA9/NDUFB7/NDUFA8/TOMM70/UQCRB/HSD17B10/MAOB/TIMM9/ATP6V0C/MDH1/COX7A2L/NDUFA2/NDUFS3/HCCS/ATP5PO/NDUFB3/COX15/SLC25A5/ATP6V0E1/ATP1B1/ATP6V1F/ISCA1/ACAT1/PMPCA/ATP5MC2/MRPL34/ECH1/MRPS12/TIMM13/NDUFC2/ETFB/NDUFB4/MRPL35/NDUFS8/SDHA/FXN/NDUFA4/GRPEL1/VDAC2/NDUFA7/SLC25A20/PRDX3/GPX4/CYB5A/PDHB/MRPS15/COX4I1/SDHD
HALLMARK_FATTY_ACID_METABOLISM HALLMARK_FATTY_ACID_METABOLISM 147 -0.261872900932232 -0.74018794806114 0.984185303514377 1 0.968421052631579 1729 tags=8%, list=10%, signal=7% ADH1C/CIDEA/INMT/GPD1/EHHADH/MIF/CEL/CYP4A22/FMO1/BMPR1B/ALDH3A1/TDO2
HALLMARK_MTORC1_SIGNALING HALLMARK_MTORC1_SIGNALING 200 -0.254942892063036 -0.744391680768122 0.99218872051242 1 0.968421052631579 6335 tags=38%, list=38%, signal=23% PSMD13/CXCR4/UNG/FADS2/SQLE/TRIB3/ENO1/P4HA1/STIP1/RPA1/PSME3/XBP1/AURKA/RPN1/MCM4/LDHA/TUBG1/CALR/USO1/PSPH/BCAT1/ACTR3/SCD/RAB1A/NFYC/IDH1/PRDX1/DDX39A/ACLY/GGA2/PGK1/NUFIP1/RRM2/CDC25A/CTH/DHFR/SLA/SLC7A5/LDLR/PPP1R15A/GSK3B/GBE1/ITGB2/M6PR/MAP2K3/CCNG1/CORO1A/SQSTM1/GAPDH/SORD/CYP51A1/PHGDH/BTG2/PGM1/SHMT2/SLC1A5/ME1/PFKL/FDXR/FGL2/ALDOA/TUBA4A/BHLHE40/PSAT1/TOMM40/DDIT4/DHCR7/MCM2/CDKN1A/PLK1/CFP/G6PD/SERPINH1/NUPR1/STC1
HALLMARK_PI3K_AKT_MTOR_SIGNALING HALLMARK_PI3K_AKT_MTOR_SIGNALING 102 -0.223750696452667 -0.604707913418534 0.998843739676247 1 0.968421052631579 503 tags=22%, list=3%, signal=21% CAB39L/SLA/RPS6KA1/GSK3B/RPTOR/MAP2K3/TNFRSF1A/TSC2/PLCB1/SQSTM1/TRAF2/PRKAG1/GRK2/NOD1/ARHGDIA/MYD88/SFN/CDKN1A/PLCG1/ADCY2/FGF17/FGF6
HALLMARK_P53_PATHWAY HALLMARK_P53_PATHWAY 195 -0.226556982664326 -0.659349689226496 0.999685830977066 1 0.968421052631579 4773 tags=30%, list=29%, signal=21% PLK3/BAIAP2/TAX1BP3/IER3/PHLDA3/NUDT15/AK1/PPP1R15A/XPC/POLH/FUCA1/ABHD4/WRAP73/PROCR/RAD9A/PITPNC1/TGFB1/MXD1/ABCC5/CD82/CCNG1/TPD52L1/TRAF4/BTG2/CCP110/TCHH/FDXR/NOTCH1/SEC61A1/PIDD1/LIF/SDC1/SERTAD3/RB1/RGS16/DDIT4/TSPYL2/EPHX1/PERP/TAP1/SFN/AEN/PLXNB2/CCND3/CDKN1A/PMM1/RRAD/CDKN2B/GPX2/SOCS1/RHBDF2/TNFSF9/NUPR1/BAK1/EPHA2/GLS2/NHLH2/ZNF365
HALLMARK_MYC_TARGETS_V1 HALLMARK_MYC_TARGETS_V1 199 0.203687285303245 0.628516964196618 0.999722684414864 1 0.968421052631579 5535 tags=33%, list=34%, signal=22% LSM7/SET/HNRNPD/NDUFAB1/EIF2S2/HSPE1/SNRPG/PRPS2/SNRPD2/RAD23B/IFRD1/ERH/RANBP1/RPL34/U2AF1/PCBP1/RPS10/H2AZ1/TOMM70/PSMB3/DDX18/CBX3/SRM/YWHAE/BUB3/NOP16/EIF1AX/SSB/SRSF2/KPNB1/RSL1D1/RPS2/HDGF/UBE2L3/HNRNPA3/PSMA4/RPS6/PSMA7/PA2G4/DUT/GSPT1/PABPC1/EIF2S1/STARD7/RFC4/SNRPB2/PSMD7/SMARCC1/ORC2/MCM6/SSBP1/EIF3B/DEK/EIF4E/SRSF3/TXNL4A/FBL/SNRPD1/CCT4/PSMB2/DHX15/AP3S1/LSM2/PRDX3/RAN
HALLMARK_ADIPOGENESIS HALLMARK_ADIPOGENESIS 195 -0.197914361575668 -0.575990954963074 1 1 0.968421052631579 5108 tags=32%, list=31%, signal=22% TANK/ACLY/TST/ALDH2/ARAF/DHRS7/DLAT/COQ5/ACAA2/UBC/TKT/SLC27A1/CD151/SCARB1/LIPE/GBE1/ITGA7/ADCY6/ESYT1/BCL2L13/RAB34/STAT5A/ACO2/PPP1R15B/UCK1/GPAM/CHCHD10/CHUK/SLC19A1/UBQLN1/PGM1/ITSN1/PFKFB3/SLC1A5/ME1/PFKL/SLC5A6/ALDOA/CRAT/ABCB8/APOE/DHCR7/MRAP/GPX3/OMD/REEP6/CD302/MIGA2/MCCC1/BCL6/PEX14/COL4A1/POR/SLC25A10/CIDEA/EPHX2/LPL/LAMA4/ANGPTL4/SPARCL1/ADIG/LIFR
HALLMARK_DNA_REPAIR HALLMARK_DNA_REPAIR 147 -0.214621759900186 -0.606631841264474 1 1 0.968421052631579 5986 tags=31%, list=36%, signal=20% CANT1/DCTN4/ARL6IP1/VPS28/DDB2/PDE4B/LIG1/NCBP2/RRM2B/POLR2C/ERCC5/SUPT5H/BCAP31/TSG101/EIF1B/MPG/NUDT21/GUK1/POLL/NELFCD/POLA2/AK1/XPC/POLH/TAF1C/ADCY6/SMAD5/VPS37B/RFC3/POLD4/SEC61A1/POLR2A/GTF3C5/SAC3D1/ERCC2/DGCR8/CLP1/POLD1/TYMS/TAF6/SNAPC4/SUPT4H1/CMPK2/BRF2/BCAM/CCNO
HALLMARK_E2F_TARGETS HALLMARK_E2F_TARGETS 200 0.146684692435322 0.45282085387033 1 1 0.968421052631579 14086 tags=100%, list=86%, signal=15% RNASEH2A/HNRNPD/ANP32E/GINS1/HMGB3/SPC24/RPA3/EXOSC8/ING3/CDKN2A/POLD3/PTTG1/CNOT9/RANBP1/NAA38/BARD1/TIPIN/CTCF/H2AZ1/SLBP/SPC25/DEPDC1/WEE1/LYAR/SRSF2/PA2G4/DUT/GSPT1/HELLS/BRCA1/EIF2S1/LUC7L3/ORC2/MCM6/PSIP1/RFC2/CDKN1B/POP7/PDS5B/DEK/CENPM/PNN/CHEK2/CKS2/DCK/PHF5A/MTHFD2/RAN/PSMC3IP/DCTPP1/TMPO/H2AX/ATAD2/SPAG5/KIF4A/NOLC1/UBR7/DIAPH3/BUB1B/SSRP1/CSE1L/NME1/MSH2/PPP1R8/STAG1/CCNE1/SUV39H1/NUP153/CHEK1/RAD51AP1/MELK/MMS22L/E2F8/BRCA2/CENPE/MYBL2/TRA2B/RAD51C/SMC4/MLH1/STMN1/NAP1L1/JPT1/RPA2/KIF2C/RAD21/UBE2T/WDR90/PPM1D/BRMS1L/PRDX4/MRE11/DONSON/NUP205/ASF1A/XPO1/GINS4/TOP2A/PCNA/RFC1/NASP/CDKN3/MAD2L1/TP53/CDK1/DSCC1/PAICS/MCM7/CDCA3/PRKDC/SMC3/IPO7/BIRC5/NUP107/POLD2/CKS1B/CCNB2/KPNA2/TFRC/SRSF1/RBBP7/NBN/ILF3/MKI67/RAD1/CDC25B/HMGB2/AK2/HMGA1/SMC6/ORC6/POLE4/SNRPB/LBR/PRPS1/CTPS1/XRCC6/NOP56/UNG/EZH2/EED/CDKN2C/SYNCRIP/RPA1/TRIP13/GINS3/AURKA/MCM4/LIG1/TUBG1/RAD50/MYC/USP1/TUBB/ZW10/CDK4/AURKB/DDX39A/POLE/ASF1B/NCAPD2/TK1/MCM3/DNMT1/SMC1A/RACGAP1/CDCA8/NUDT21/MCM5/RRM2/TACC3/CDC25A/TCF19/SHMT1/POLA2/PLK4/CBX5/HMMR/DCLRE1B/RFC3/KIF22/CDC20/MXD3/DLGAP5/PAN2/CCP110/PRIM2/TBRG4/LMNB1/CIT/HUS1/PMS2/UBE2S/POLD1/TIMELESS/MCM2/ESPL1/CDKN1A/PLK1/KIF18B
HALLMARK_G2M_CHECKPOINT HALLMARK_G2M_CHECKPOINT 198 0.137572964669739 0.424138287429977 1 1 0.968421052631579 14234 tags=100%, list=86%, signal=14% SAP30/PBK/PURA/EGF/SMAD3/UPF1/HNRNPD/FANCC/KMT5A/MEIS1/MEIS2/MT2A/HIF1A/ARID4A/HMGB3/EFNA5/RAD23B/PTTG1/NUP50/CUL5/TNPO2/BARD1/DR1/CTCF/KIF15/H2AZ1/CCND1/MNAT1/HMGN2/HIRA/SLC12A2/MARCKS/BUB3/CCNT1/ATRX/ATF5/FOXN3/DTYMK/SRSF2/MAP3K20/KPNB1/GSPT1/CCNF/RPS6KA5/MTF2/SMARCC1/MCM6/SFPQ/CDKN1B/E2F3/PDS5B/H2BC12/SNRPD1/CKS2/TLE3/YTHDC1/POLQ/TMPO/PAFAH1B1/H2AX/PRC1/TOP1/PRPF4B/SLC7A1/KIF4A/DKC1/NOLC1/CDC45/KIF5B/BUB1/SS18/STAG1/NSD2/E2F1/SRSF10/SUV39H1/CHAF1A/H2AZ2/CHEK1/NUP98/CDC27/ORC5/DBF4/TPX2/CENPF/BRCA2/CENPE/MYBL2/TRA2B/SMC4/STMN1/JPT1/CUL4A/EXO1/RPA2/KIF2C/TRAIP/RAD21/SMC2/HNRNPU/NEK2/CASP8AP2/ABL1/CDC7/RBM14/RBL1/XPO1/TOP2A/G3BP1/SLC38A1/NASP/UBE2C/CDKN3/MAD2L1/CDK1/EWSR1/KATNA1/BIRC5/CKS1B/CCNB2/KPNA2/SRSF1/RASAL2/ILF3/MKI67/CENPA/TFDP1/CDC25B/CBX1/E2F2/NDC80/KNL1/HMGA1/MAPK14/ODC1/ORC6/AMD1/UCK2/LBR/HSPA8/CUL1/SQLE/EZH2/CDKN2C/SYNCRIP/NCL/AURKA/MYC/NUMA1/INCENP/CDC6/CDK4/TTK/DMD/AURKB/DDX39A/POLE/KIF20B/MCM3/SMC1A/RACGAP1/MCM5/CUL3/TACC3/ODF2/CDC25A/FBXO5/WRN/BCL3/SLC7A5/E2F4/POLA2/TROAP/CCNA2/STIL/GINS2/TENT4A/PML/PLK4/TGFB1/HMMR/KIF11/PRMT5/KIF22/CDC20/PRIM2/NUSAP1/CHMP1A/LMNB1/HUS1/KIF23/LIG3/UBE2S/NOTCH2/MCM2/ESPL1/PLK1/RAD54L
HALLMARK_HEME_METABOLISM HALLMARK_HEME_METABOLISM 193 0.215844528242277 0.663287266179786 1 1 0.968421052631579 861 tags=4%, list=5%, signal=3% TSPO2/AHSP/C3/MOCOS/SLC6A8/SLC4A1/HBQ1
HALLMARK_PROTEIN_SECRETION HALLMARK_PROTEIN_SECRETION 94 0.15493941579042 0.435659529054089 1 1 0.968421052631579 2816 tags=12%, list=17%, signal=10% TOM1L1/SSPN/ABCA1/VAMP4/IGF2R/DOP1A/GOLGA4/RAB22A/GNAS/ANP32E/YIPF6
HALLMARK_UNFOLDED_PROTEIN_RESPONSE HALLMARK_UNFOLDED_PROTEIN_RESPONSE 111 -0.110487476504993 -0.301017001381393 1 1 0.968421052631579 6651 tags=36%, list=40%, signal=22% HSPA5/SERP1/ATF3/ZBTB17/EXOSC5/DNAJB9/CNOT2/NOP56/ATF6/TARS1/PREB/DDX10/EIF4A1/SEC31A/XBP1/NOP14/GEMIN4/CALR/ATP6V0D1/PDIA6/CXXC1/EEF2/MTREX/EIF4A2/SLC7A5/ARFGAP1/TUBB2A/SRPRA/CHAC1/EDC4/DNAJA4/ALDH18A1/EIF4G1/PSAT1/SHC1/DDIT4/TSPYL2/DCTN1/HYOU1/WFS1
unstrand_96h/GE_ANAK_96h-GE_96h-gsea-sasp.txt
0 → 100755
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f9b173e7
ID Description setSize enrichmentScore NES pvalue p.adjust qvalues rank leading_edge core_enrichment
SASP_SCHLEICH SASP_SCHLEICH 71 0.403124405870107 1.08611987172211 0.288588957055215 0.577177914110429 0.577177914110429 1073 tags=15%, list=7%, signal=15% IL13/CSF3/IL6/IGF1/IFNG/MMP12/FGF2/SERPINB2/CCL25/IL1A/IGFBP5
CLASSICAL_SASP CLASSICAL_SASP 33 0.383078093169488 0.902317321169975 0.61533133225583 0.61533133225583 0.61533133225583 909 tags=18%, list=6%, signal=17% IL13/IL6/IFNG/FGF2/IL1A/EFEMP1
unstrand_96h/GE_ANAK_96h-GE_96h-gsea-senescence_signatures.txt
0 → 100755
View file @
f9b173e7
ID Description setSize enrichmentScore NES pvalue p.adjust qvalues rank leading_edge core_enrichment
SenMayo SenMayo 107 0.392337272109938 1.12577045492042 0.206626201315124 0.839921171171171 0.839921171171171 1788 tags=21%, list=11%, signal=19% IL13/IL32/WNT16/IL6/FGF1/IGF1/C3/CCL26/CCL16/MMP12/FGF2/IL1A/SEMA3F/IGFBP5/CCL8/ANG/CCL3/SPP1/CCL4/PAPPA/ITPKA/EGF/AREG
Casella Casella 48 0.3987666092173 1.01403504237443 0.424693106704438 0.839921171171171 0.839921171171171 1397 tags=10%, list=8%, signal=10% PTCHD4/DIO2/RND3/JCAD/TMSB15A
Purcell Purcell 45 0.393501206520859 0.989936553870855 0.463883677298311 0.839921171171171 0.839921171171171 846 tags=9%, list=5%, signal=8% IL32/C3/MMP12/IL1A
Sencan Sencan 29 0.405529522339258 0.935645025167595 0.550936500685244 0.839921171171171 0.839921171171171 1750 tags=41%, list=11%, signal=37% LUM/IL6/MMP12/LCN2/SERPINB2/IL1A/SLAMF1/CLCA2/CCL3/TAC3/TREM2/FOLR3
Pribluda_SENESCENCE_INFLAMMATORY_GENES Pribluda_SENESCENCE_INFLAMMATORY_GENES 93 0.323018183530495 0.909378283103429 0.666583416583417 0.839921171171171 0.839921171171171 1368 tags=12%, list=8%, signal=11% IL13/MSX2/IL6/IGF1/CPA2/PLA2G2F/HAMP/IL1A/IGFBP5/ANG/CCL3
FRIDMAN_SENESCENCE_UP FRIDMAN_SENESCENCE_UP 75 -0.334852796598582 -0.86947048348795 0.719932432432432 0.839921171171171 0.839921171171171 2152 tags=17%, list=13%, signal=15% IGFBP7/CDKN1A/FN1/CITED2/TNFAIP3/CXCL14/CDKN2B/IGSF3/F3/ALDH1A3/TFAP2A/IGFBP3/MMP1
Hernandez Hernandez 53 0.267334426062172 0.68887978757332 0.969227099236641 0.969227099236641 0.969227099236641 62 tags=2%, list=0%, signal=2% EFNB3
unstrand_96h/GE_ANAK_96h-RNP_NEG_96h-gsea-h.all.v7.2.symbols.txt
0 → 100755
View file @
f9b173e7
ID Description setSize enrichmentScore NES pvalue p.adjust qvalues rank leading_edge core_enrichment
HALLMARK_INFLAMMATORY_RESPONSE HALLMARK_INFLAMMATORY_RESPONSE 189 0.557559516169342 1.74846174044331 0.000155327741534638 0.0077663870767319 0.00719412697634113 2419 tags=31%, list=15%, signal=27% SLC1A2/CSF3/HAS2/MEFV/PCDH7/CXCL10/CXCL11/CCL22/IL6/VIP/LTA/CD70/CDKN1A/MET/HPN/SELE/EBI3/EDN1/CMKLR1/KCNJ2/TNFSF9/CCL2/RGS1/INHBA/OPRK1/TNFAIP6/RGS16/IL7R/KCNMB2/IL1R1/MSR1/IL1A/CXCL8/CCL17/SERPINE1/SLC28A2/ABCA1/CCL24/CCL5/IL10/FPR1/TNFRSF9/TACR1/HBEGF/AQP9/TNFSF15/CD14/C5AR1/MMP14/HRH1/TIMP1/KLF6/ITGB3/RNF144B/C3AR1/SLC31A2/IL18R1/ATP2B1/CLEC5A
HALLMARK_E2F_TARGETS HALLMARK_E2F_TARGETS 200 -0.394039319517496 -1.3206062975952 0.0193017314788533 0.262913702443551 0.243541113842447 6345 tags=57%, list=39%, signal=36% MCM7/DEK/AK2/PPM1D/HMGA1/CKS2/MTHFD2/PRDX4/PAICS/DNMT1/CHEK2/EZH2/EIF2S1/MLH1/MSH2/UBE2T/MMS22L/CHEK1/NUP205/ANP32E/UBR7/AURKB/LIG1/TOP2A/ESPL1/SMC6/RBBP7/SNRPB/SRSF2/CSE1L/TFRC/KPNA2/POLE/PRPS1/PDS5B/ASF1A/GSPT1/PRKDC/SYNCRIP/RAD1/RPA1/MCM5/TIPIN/KIF2C/KIF4A/RPA2/ASF1B/RAD21/MCM6/SPAG5/DIAPH3/CCP110/XRCC6/TBRG4/SMC4/DSCC1/MCM4/DEPDC1/CIT/CDC25B/TUBB/DONSON/TK1/NBN/CBX5/CKS1B/CDCA8/TMPO/NCAPD2/RACGAP1/CDKN3/CCNB2/KIF22/HUS1/CDKN2C/CDK4/SRSF1/ZW10/MAD2L1/UNG/SHMT1/MELK/HMMR/LMNB1/TIMELESS/POLD1/TRIP13/PRIM2/USP1/TUBG1/RRM2/GINS3/SMC1A/SLBP/E2F8/RAD50/CDK1/LBR/TCF19/MCM3/BRMS1L/DCK/CDC20/NUDT21/MYC/PLK4/DLGAP5/PLK1/DCLRE1B/KIF18B/RFC3/MCM2/AURKA/PAN2/UBE2S
HALLMARK_ESTROGEN_RESPONSE_LATE HALLMARK_ESTROGEN_RESPONSE_LATE 186 -0.39548248799492 -1.3158196566445 0.0221536735838474 0.262913702443551 0.243541113842447 1945 tags=20%, list=12%, signal=18% PLK4/TSPAN13/SORD/IL6ST/XRCC3/SLC16A1/CISH/HMGCS2/PDLIM3/CALCR/ST6GALNAC2/FOXC1/DHCR7/UNC13B/XBP1/DYNLT3/PTGER3/MEST/OVOL2/PDZK1/SULT2B1/SCUBE2/CLIC3/OPN3/SEMA3B/PRSS23/CXCL14/RET/CXCL12/KRT13/TJP3/PTGES/TFPI2/CA12/PLAC1/TRIM29/CDH1
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION 179 0.432968010300355 1.35102291468827 0.0223857232310582 0.262913702443551 0.243541113842447 2112 tags=28%, list=13%, signal=25% MFAP5/LUM/SCG2/APLP1/NNMT/IL6/BGN/SLIT2/CDH6/THBS2/IL32/FMOD/SFRP1/SLC6A8/COL4A2/PCOLCE2/HTRA1/WNT5A/COMP/BDNF/FZD8/MGP/MYL9/LAMA2/TGFBI/TPM2/INHBA/CCN2/ACTA2/CDH2/ITGB5/ABI3BP/CXCL8/COL3A1/FOXC2/SERPINE1/COL1A2/COL8A2/SPP1/NT5E/CCN1/COL16A1/LAMA3/SDC1/VCAN/IGFBP2/MMP14/TIMP1/GADD45A/ITGB3/LGALS1
HALLMARK_TNFA_SIGNALING_VIA_NFKB HALLMARK_TNFA_SIGNALING_VIA_NFKB 199 0.420833560978237 1.32686680507084 0.0262913702443551 0.262913702443551 0.243541113842447 2643 tags=31%, list=16%, signal=26% CXCL10/CXCL11/IL6/CDKN1A/CCL4/EDN1/PLPP3/NR4A2/NR4A1/SERPINB2/TNFSF9/CCL2/IL23A/INHBA/TNFAIP6/IL7R/IL1A/CCND1/KLF2/SERPINE1/ABCA1/NFIL3/CXCL3/ATF3/PLK2/PHLDA1/CCL5/IER5/KYNU/TNFRSF9/BCL2A1/HBEGF/CCN1/EGR2/TNF/EGR1/KLF9/CEBPD/KLF4/IFIH1/GADD45A/KLF6/SOD2/PTGS2/SAT1/CD80/RNF19B/B4GALT1/DUSP4/AREG/BCL3/EGR3/ATP2B1/DUSP5/ACKR3/LIF/CXCL2/RHOB/JUN/YRDC/IFIT2/VEGFA
HALLMARK_MYC_TARGETS_V2 HALLMARK_MYC_TARGETS_V2 57 -0.487325345237895 -1.37378967096152 0.0498812351543943 0.415676959619953 0.385048131016377 6001 tags=63%, list=36%, signal=40% TCOF1/PPRC1/HSPD1/EXOSC5/GRWD1/MYBBP1A/RABEPK/NPM1/WDR43/MCM5/PES1/WDR74/LAS1L/NOP2/RCL1/TBRG4/NIP7/MCM4/DUSP2/PRMT3/SLC29A2/CDK4/UNG/NOC4L/RRP12/TFB2M/MAP3K6/IPO4/TMEM97/BYSL/SLC19A1/MYC/PLK4/PLK1/SORD/PPAN
HALLMARK_WNT_BETA_CATENIN_SIGNALING HALLMARK_WNT_BETA_CATENIN_SIGNALING 40 0.5447982377946 1.3705079287585 0.0773819968415511 0.464792005577504 0.430544173587583 962 tags=15%, list=6%, signal=14% HEY1/WNT1/DKK4/WNT6/FZD8/DLL1
HALLMARK_MYOGENESIS HALLMARK_MYOGENESIS 179 0.392862249645434 1.22587786847986 0.0815591734502192 0.464792005577504 0.430544173587583 1747 tags=23%, list=11%, signal=21% PTGIS/APOD/LARGE1/IGF1/ACTN3/HRC/ACHE/DMD/SLC6A8/COL4A2/FXYD1/MB/CDKN1A/MYH2/COX7A1/LAMA2/TPM2/COL15A1/GNAO1/CTF1/KLF5/ITGB5/WWTR1/LDB3/SH3BGR/TNNT1/NCAM1/SPDEF/TNNI1/COL3A1/STC2/MYH8/MYH4/FST/CAMK2B/TNNC1/MYOZ1/DTNA/SCHIP1/HBEGF/ADCY9
HALLMARK_APICAL_SURFACE HALLMARK_APICAL_SURFACE 40 -0.506822617281444 -1.33547621715966 0.0836625610039507 0.464792005577504 0.430544173587583 1648 tags=28%, list=10%, signal=25% SLC34A3/IL2RB/SCUBE1/NTNG1/TMEM8B/SRPX/THY1/RTN4RL1/GAS1/MAL/PCSK9
HALLMARK_HEDGEHOG_SIGNALING HALLMARK_HEDGEHOG_SIGNALING 32 0.543219391265269 1.31157336442676 0.117155555555556 0.585777777777778 0.542615204678363 1669 tags=25%, list=10%, signal=23% SCG2/HEY1/SHH/ACHE/NKX6-1/GLI1/NRP1/NRCAM
HALLMARK_KRAS_SIGNALING_DN HALLMARK_KRAS_SIGNALING_DN 157 0.382263473181434 1.17387591641457 0.144557283402095 0.651308304891923 0.603317166636728 2004 tags=25%, list=12%, signal=23% SYNPO/MEFV/RYR2/PROP1/SCN10A/CPA2/WNT16/CAPN9/PDCD1/P2RX6/CACNA1F/SCGB1A1/TG/EFHD1/CYP39A1/SOX10/MYO15A/TENM2/LGALS7/EDN1/RGS11/NR4A2/FGFR3/IL5/SERPINB2/THRB/THNSL2/MX1/SHOX2/CDH16/TNNI3/ITIH3/IFI44L/TSHB/UPK3B/TFCP2L1/CALCB/MAGIX/IGFBP2/PTPRJ
HALLMARK_PANCREAS_BETA_CELLS HALLMARK_PANCREAS_BETA_CELLS 28 -0.513632748081995 -1.26132619139811 0.156313993174061 0.651308304891923 0.603317166636728 257 tags=18%, list=2%, signal=18% SRP9/CHGA/PAX6/ISL1/PKLR
HALLMARK_P53_PATHWAY HALLMARK_P53_PATHWAY 195 0.3593642506011 1.13060653847917 0.185822863347293 0.667297934681627 0.61812861317877 2961 tags=28%, list=18%, signal=23% KRT17/EPHA2/PHLDA3/CDKN1A/ZMAT3/TNFSF9/NUPR1/RRAD/RPS27L/RGS16/FDXR/MDM2/IL1A/PDGFA/TNNI1/DDIT3/ATF3/UPP1/PLK2/TGFA/TCHH/IER5/HMOX1/IFI30/HBEGF/SDC1/FGF13/OSGIN1/BAX/SESN1/KLF4/DDB2/GADD45A/SAT1/RNF19B/TSPYL2/ZFP36L1/RAP2B/JAG2/POLH/LIF/JUN/TRIAP1/CD81/XPC/ABHD4/S100A4/VAMP8/SLC7A11/PLK3/RALGDS/AEN/HRAS/FAM162A
HALLMARK_ANDROGEN_RESPONSE HALLMARK_ANDROGEN_RESPONSE 97 -0.371754087488003 -1.14287896204145 0.186843421710855 0.667297934681627 0.61812861317877 3035 tags=35%, list=18%, signal=29% TPD52/NCOA4/MERTK/NKX3-1/TSC22D1/SEC24D/CCND3/H1-0/XRCC6/UAP1/ZBTB10/UBE2J1/INSIG1/GNAI3/DNAJB9/HMGCR/GUCY1A1/RRP12/MAK/ELOVL5/RAB4A/IDI1/GPD1L/PGM3/FKBP5/HMGCS1/SCD/SORD/PTPN21/ALDH1A3/STEAP4/ADAMTS1/BMPR1B/LIFR
HALLMARK_APOPTOSIS HALLMARK_APOPTOSIS 161 0.353184270311679 1.08913838871574 0.271050141911069 0.882682857346343 0.817643067857665 2582 tags=21%, list=16%, signal=18% LUM/IL6/BGN/FEZ1/CDKN1A/PLAT/F2/CAV1/FDXR/IL1A/CCND1/DDIT3/GUCY2D/ATF3/HMOX1/AIFM3/TNF/BAX/CD14/CD38/TIMP1/GADD45A/DIABLO/SOD2/SAT1/GPX1/LGALS3/EGR3/EMP1/IGFBP6/CCNA1/RHOB/JUN/LMNA
HALLMARK_ESTROGEN_RESPONSE_EARLY HALLMARK_ESTROGEN_RESPONSE_EARLY 189 -0.316826257056395 -1.05720522067695 0.297979797979798 0.882682857346343 0.817643067857665 1844 tags=19%, list=11%, signal=17% IL6ST/LRIG1/ASB13/SLC16A1/CISH/INHBB/BCL11B/PDLIM3/CALCR/P2RY2/FOXC1/DHCR7/XBP1/DYNLT3/TTC39A/AQP3/ELOVL2/FASN/OVOL2/ADCY1/PDZK1/SULT2B1/REEP1/CLIC3/OPN3/SEMA3B/PRSS23/RET/RAB17/CXCL12/SYBU/TGM2/KRT13/TJP3/PTGES/CA12
HALLMARK_HYPOXIA HALLMARK_HYPOXIA 192 0.338308635905874 1.06233429033997 0.308766485647789 0.882682857346343 0.817643067857665 1975 tags=17%, list=12%, signal=15% TKTL1/ERRFI1/LARGE1/GPC4/IL6/BGN/CAVIN3/MT1E/CDKN1A/SDC2/CAV1/GAPDHS/TGFBI/PHKG1/HAS1/CCN2/NCAN/KDELR3/SDC3/STC2/CDKN1C/SERPINE1/NFIL3/DDIT3/ATF3/DTNA/CCN5/HMOX1/SAP30/CCN1/SELENBP1/DPYSL4/MT2A
HALLMARK_KRAS_SIGNALING_UP HALLMARK_KRAS_SIGNALING_UP 181 -0.314114838338016 -1.04217132981803 0.333148096693526 0.882682857346343 0.817643067857665 1834 tags=15%, list=11%, signal=14% TSPAN13/ETV1/ABCB1/TSPAN7/G0S2/IGFBP3/PDCD1LG2/BPGM/FLT4/GFPT2/ANGPTL4/CFB/SPON1/CBX8/F2RL1/MALL/BMP2/SEMA3B/GADD45G/ALDH1A3/IL1RL2/NR0B2/CCL20/SLPI/GPRC5B/ITGBL1/GABRA3/SNAP25
HALLMARK_IL6_JAK_STAT3_SIGNALING HALLMARK_IL6_JAK_STAT3_SIGNALING 80 0.377679082242162 1.06624040331399 0.33541948579161 0.882682857346343 0.817643067857665 2580 tags=24%, list=16%, signal=20% CXCL10/CXCL11/IL6/EBI3/CXCL13/IL1R1/CXCL3/HMOX1/PF4/TNF/CD14/CD38/ITGB3/ACVRL1/IL10RB/IL1R2/IL18R1/A2M/JUN
HALLMARK_COMPLEMENT HALLMARK_COMPLEMENT 192 0.329576186699363 1.03491323380711 0.369433669511249 0.921810068805777 0.853887221630614 2524 tags=24%, list=15%, signal=21% F7/IL6/MMP12/HPCAL4/COL4A2/GZMB/C1S/F5/PLAT/F2/C1QC/PLA2G7/C3/SERPINB2/C1QA/DOCK4/GNGT2/S100A12/SERPINA1/LGMN/S100A9/CR1/CTSL/SERPINC1/SERPINE1/L3MBTL4/CCL5/PCLO/CPM/KYNU/CASP5/NOTCH4/FCN1/MMP14/GP9/TIMP1/FYN/LGALS3/CD40LG/DOCK9/CTSH/DUSP5/KCNIP3/ACTN2/HSPA1A/LRP1
HALLMARK_NOTCH_SIGNALING HALLMARK_NOTCH_SIGNALING 31 0.438913704034583 1.05223339990486 0.387160228898426 0.921810068805777 0.853887221630614 3425 tags=35%, list=21%, signal=28% WNT5A/DLL1/DTX1/CCND1/NOTCH3/SAP30/RBX1/HES1/PRKCA/ST3GAL6/PSEN2
HALLMARK_ALLOGRAFT_REJECTION HALLMARK_ALLOGRAFT_REJECTION 193 0.322859793032287 1.0147938341413 0.414535874786921 0.942126988152093 0.87270710481457 2574 tags=18%, list=16%, signal=15% IL13/CCL22/IL6/ACHE/GZMB/IL4/CCL4/F2/CRTAM/IGSF6/CXCL13/CCL2/INHBA/CD1D/MMP9/IRF4/CD247/CCL5/IL10/RPS19/PF4/TNF/SIT1/CCR5/TIMP1/CD80/STAT4/CD40LG/TLR6/BCL3/CD3D/LIF/TRAT1/FYB1/EIF4G3
HALLMARK_XENOBIOTIC_METABOLISM HALLMARK_XENOBIOTIC_METABOLISM 183 0.321454079453361 1.00503734460874 0.434999221547563 0.945650481625138 0.875970972452759 2163 tags=19%, list=13%, signal=16% FMO3/HGFAC/EPHA2/CYP1A2/IGF1/SLC6A12/ATOH8/SLC22A1/CDO1/PTGDS/DDC/CYP27A1/GNMT/IL1R1/ABCC2/ABCD2/CYP26A1/CYP17A1/HSD17B2/SERPINE1/UPP1/MPP2/KYNU/HMOX1/CCL25/RBP4/CROT/AQP9/TMEM176B/MT2A/GAD1/LCAT/ABCC3/AKR1C2
HALLMARK_SPERMATOGENESIS HALLMARK_SPERMATOGENESIS 113 0.333280568086342 0.985456399432484 0.483349818661391 0.968361754623463 0.897008783230155 1634 tags=16%, list=10%, signal=14% TKTL1/DMRT1/SEPTIN4/PACRG/ACTL7B/CFTR/ZPBP/ELOVL3/OAZ3/GSG1/TEKT2/GAPDHS/ADCYAP1/TNNI3/DPEP3/CHRM4/ACRBP/CAMK4
HALLMARK_TGF_BETA_SIGNALING HALLMARK_TGF_BETA_SIGNALING 54 -0.349740780305893 -0.977798086353374 0.494095418044402 0.968361754623463 0.897008783230155 733 tags=7%, list=4%, signal=7% TGFB1/BMP2/BMPR1A/CDH1
HALLMARK_MTORC1_SIGNALING HALLMARK_MTORC1_SIGNALING 200 -0.29285184835059 -0.981480720420877 0.503548112404201 0.968361754623463 0.897008783230155 5999 tags=51%, list=36%, signal=33% PNO1/BCAT1/NFYC/HSPD1/RAB1A/WARS1/DHCR24/NUP205/UFM1/CANX/TES/FADS1/CORO1A/PSMG1/GOT1/GTF2H1/PRDX1/SKAP2/SERPINH1/TFRC/MAP2K3/GCLC/ENO1/G6PD/GSK3B/ELOVL6/PDK1/M6PR/FADS2/CACYBP/HSPA9/SRD5A1/RPA1/PSMD14/CFP/RPN1/HMBS/EPRS1/SC5D/PSME3/TCEA1/UCHL5/PITPNB/UBE2D3/MCM4/AK4/COPS5/LTA4H/GMPS/HPRT1/PFKL/ADD3/INSIG1/DHFR/CTSC/P4HA1/GBE1/SHMT2/NUFIP1/SLC7A5/IDH1/PSPH/PHGDH/USO1/UNG/HMGCR/SLC2A1/BUB1/SLC37A4/ACTR3/TUBG1/RRM2/PGK1/ALDOA/PPA1/GAPDH/ACLY/EEF1E1/ELOVL5/STARD4/TMEM97/IDI1/LDHA/SLC1A5/SQLE/CCNG1/CALR/PGM1/TUBA4A/TRIB3/HMGCS1/PLK1/SCD/SORD/CYP51A1/ASNS/TOMM40/MCM2/DHCR7/AURKA/XBP1/PSAT1
HALLMARK_UV_RESPONSE_DN HALLMARK_UV_RESPONSE_DN 139 0.315467879857251 0.956185053952434 0.547611413914716 0.98022382029735 0.90799680195965 2406 tags=17%, list=15%, signal=14% HAS2/MT1E/PPARG/MET/RND3/EFEMP1/BDNF/PLPP3/SDC2/CAV1/COL3A1/SERPINE1/NRP1/SCHIP1/COL1A2/KCNMA1/CCN1/NFIB/ITGB3/FYN/DLC1/KALRN/ATP2B1
HALLMARK_MYC_TARGETS_V1 HALLMARK_MYC_TARGETS_V1 199 -0.288562907059103 -0.967318127798998 0.548925339366516 0.98022382029735 0.90799680195965 6764 tags=50%, list=41%, signal=30% GLO1/SRPK1/CNBP/AP3S1/GNL3/CDK2/ETF1/ORC2/MRPL9/SRSF7/MCM7/DEK/MRPS18B/EEF1B2/RFC4/PRDX4/SF3A1/PWP1/PPM1G/EIF2S1/PRPS2/HSPD1/SERBP1/DDX21/CCT7/TARDBP/CANX/EIF3J/IARS1/TXNL4A/PSMD8/POLE3/SRSF2/TUFM/BUB3/NPM1/KPNA2/VDAC3/PHB2/CAD/GSPT1/SF3B3/XPOT/SYNCRIP/DHX15/ILF2/CYC1/CCT3/VDAC1/MCM5/PSMD14/ACP1/EPRS1/CDC45/GOT2/TCP1/CSTF2/MCM6/PRDX3/PSMA6/HNRNPA2B1/XRCC6/TOMM70/CCT5/MCM4/HDAC2/COPS5/EIF4G2/UBE2E1/CLNS1A/NCBP2/EIF4E/HPRT1/TFDP1/EIF4H/PTGES3/APEX1/PSMA1/HNRNPR/CDK4/SRSF1/MAD2L1/VBP1/RRM1/YWHAQ/SLC25A3/USP1/PSMD3/ODC1/SNRPA/PGK1/ABCE1/LDHA/CDC20/UBA2/MYC/MRPL23/MCM2/TYMS/CCNA2
HALLMARK_BILE_ACID_METABOLISM HALLMARK_BILE_ACID_METABOLISM 102 0.320548224819628 0.935184793687571 0.596179401993356 1 0.926315789473684 1943 tags=17%, list=12%, signal=15% HAO1/ABCA4/DIO2/TTR/CYP39A1/ABCA6/PIPOX/BMP6/CYP27A1/GNMT/FDXR/ABCD2/ABCA1/EPHX2/CROT/AQP9/TFCP2L1
HALLMARK_PEROXISOME HALLMARK_PEROXISOME 99 0.315504530387537 0.916464762515961 0.632323568575233 1 0.926315789473684 3264 tags=20%, list=20%, signal=16% TTR/ALB/SCGB1A1/CRABP2/ABCD2/CACNA1B/SEMA3C/EPHX2/DHRS3/SOD2/CTBP1/HSD3B7/CRABP1/DLG4/SIAH1/MLYCD/HRAS/DIO1/ABCB4/MVP
HALLMARK_CHOLESTEROL_HOMEOSTASIS HALLMARK_CHOLESTEROL_HOMEOSTASIS 72 -0.312738631758282 -0.9142801430783 0.636651253346313 1 0.926315789473684 3072 tags=32%, list=19%, signal=26% FDFT1/HMGCR/ALCAM/ACAT2/SREBF2/STARD4/TMEM97/IDI1/SQLE/ALDOC/TRIB3/HMGCS1/SCD/MVK/CYP51A1/DHCR7/FASN/PCYT2/CBS/SEMA3B/LPL/ADH4/AVPR1A
HALLMARK_ANGIOGENESIS HALLMARK_ANGIOGENESIS 32 0.363147313100365 0.876799228606687 0.652622222222222 1 0.926315789473684 2806 tags=44%, list=17%, signal=36% LUM/PGLYRP1/PDGFA/COL3A1/SLCO2A1/NRP1/SPP1/PF4/VCAN/TIMP1/JAG2/VEGFA/PRG2/S100A4
HALLMARK_COAGULATION HALLMARK_COAGULATION 121 0.303853112410849 0.906169634581639 0.670759659462999 1 0.926315789473684 2652 tags=29%, list=16%, signal=24% TF/CRIP2/C1S/CPB2/HPN/HTRA1/COMP/PLAT/F2/C3/SERPINB2/C1QA/GNG12/MMP9/SERPINA1/LGMN/SERPINC1/SERPINE1/MMP11/CTSK/PROC/PF4/MMP14/GP9/TIMP1/CTSE/ITGB3/FYN/F9/CTSH/A2M/LRP1/C8G/CFD/THBS1
HALLMARK_APICAL_JUNCTION HALLMARK_APICAL_JUNCTION 182 -0.276440265647526 -0.917780044166443 0.710987482614743 1 0.926315789473684 1664 tags=13%, list=10%, signal=11% CADM3/CDSN/EGFR/NFASC/ADAM15/FLNC/NRXN2/TMEM8B/LAYN/ICAM5/CLDN4/SLC30A3/CLDN5/THY1/IRS1/PDZD3/CDH4/AMH/CD209/ACTA1/CLDN19/WNK4/CDH1
HALLMARK_IL2_STAT5_SIGNALING HALLMARK_IL2_STAT5_SIGNALING 195 0.286112835575549 0.900148086804551 0.724678144873585 1 0.926315789473684 3001 tags=23%, list=18%, signal=19% IL13/APLP1/PTH1R/CXCL10/DRC1/BATF3/RGS16/SPRY4/SERPINC1/CTLA4/CDKN1C/FLT3LG/NFIL3/IRF4/NRP1/PHLDA1/IL10/SPP1/TNFRSF9/NT5E/ETV4/COL6A1/CKAP4/DHRS3/KLF6/SELP/IL1R2/PLPP1/PLEC/IL18R1/MYO1E/EMP1/LIF/ADAM19/RHOB/NCS1/CD81/TLR7/IGF2R/PUS1/TTC39B/IL2RA/HIPK2/FGL2
HALLMARK_HEME_METABOLISM HALLMARK_HEME_METABOLISM 193 -0.26431139250475 -0.883630300911388 0.82276697661313 1 0.926315789473684 2619 tags=18%, list=16%, signal=15% LAMP2/PC/ABCB6/GDE1/PPOX/BACH1/NEK7/NNT/ARL2BP/CAT/CLIC2/RNF123/P4HA2/ASNS/SLC10A3/KEL/ABCG2/IGSF3/BPGM/AQP3/BTRC/CA1/GYPB/KLF1/BCAM/RHAG/ANK1/RHCE/AHSP/XK/ALAS2/HBB/EPB42/GYPA
HALLMARK_PROTEIN_SECRETION HALLMARK_PROTEIN_SECRETION 94 -0.274274070311272 -0.838638812956599 0.836668334167084 1 0.926315789473684 4856 tags=33%, list=29%, signal=23% M6PR/AP2M1/TMED10/TPD52/GALC/ARFIP1/STX12/OCRL/SEC24D/ATP6V1H/RAB2A/ATP7A/GBF1/RAB5A/VPS4B/AP3B1/CTSC/SCRN1/USO1/ZW10/RAB14/SCAMP1/NAPA/LAMP2/BET1/SSPN/TMX1/EGFR/RAB9A/CAV2/SH3GL2
HALLMARK_INTERFERON_GAMMA_RESPONSE HALLMARK_INTERFERON_GAMMA_RESPONSE 197 0.269331313733868 0.848452538398602 0.860677284676048 1 0.926315789473684 3598 tags=25%, list=22%, signal=20% CXCL10/CXCL11/IL6/C1S/CDKN1A/SECTM1/CMKLR1/KLRK1/CCL2/TNFAIP6/MX1/CD274/IRF4/UPP1/CCL5/FPR1/IFI30/IFI44L/ISG15/MT2A/IFIH1/CD38/SOD2/PTGS2/SELP/ZNFX1/STAT4/SLAMF7/IFIT2/IL18BP/PARP12/P2RY14/TRIM21/VAMP8/FGL2/ST3GAL5/HIF1A/APOL6/VAMP5/CD69/MVP/LATS2/RNF213/IFITM3/NFKBIA/IFITM2/C1R/HLA-DRB1/HLA-DMA/BST2
HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY 49 -0.279621118965054 -0.766800217068417 0.882243425645799 1 0.926315789473684 5368 tags=39%, list=33%, signal=26% TXNRD2/PRDX1/PRDX2/LSP1/GCLC/OXSR1/G6PD/MSRA/CDKN2D/FES/PTPA/HHEX/ERCC2/STK25/PRNP/MGST1/CAT/MPO/SRXN1
HALLMARK_GLYCOLYSIS HALLMARK_GLYCOLYSIS 193 0.258133394328615 0.811349640320335 0.925461025879436 1 0.926315789473684 2251 tags=12%, list=14%, signal=11% TKTL1/GPC4/ARTN/GPR87/MET/SOX9/HS6ST2/SDC2/GAPDHS/TGFBI/KDELR3/SDC3/STC2/TGFA/SAP30/NT5E/SDC1/VCAN/DPYSL4/CLDN9/XYLT2/PFKFB1/B4GALT1/B3GALT6
HALLMARK_UV_RESPONSE_UP HALLMARK_UV_RESPONSE_UP 152 0.253168947383419 0.774403729541562 0.952282157676348 1 0.926315789473684 2755 tags=18%, list=17%, signal=15% MAPK8IP2/IL6/SLC6A12/SLC6A8/CDO1/NR4A1/FGF18/RRAD/SHOX2/CDKN1C/PLCL1/ATF3/TCHH/HMOX1/HSPA2/E2F5/IGFBP2/MMP14/CHKA/SOD2/AGO2/CXCL2/RHOB/COL2A1/NPTX2/DLG4/PRPF3/ATP6V1F
HALLMARK_INTERFERON_ALPHA_RESPONSE HALLMARK_INTERFERON_ALPHA_RESPONSE 97 0.251739063340258 0.729696637542715 0.958694203864091 1 0.926315789473684 1984 tags=8%, list=12%, signal=7% CXCL10/CXCL11/C1S/MX1/IFI30/IFI44L/ISG15/IFIH1
HALLMARK_FATTY_ACID_METABOLISM HALLMARK_FATTY_ACID_METABOLISM 147 -0.234717062376509 -0.759284182107196 0.976688741721854 1 0.926315789473684 5226 tags=41%, list=32%, signal=29% BPHL/SLC22A5/MCEE/GCDH/PPARA/ALDH3A2/GRHPR/SDHD/HADH/HSDL2/ACADM/SDHA/AUH/RETSAT/ACO2/AADAT/PDHB/CPT2/ACSL5/ALAD/REEP6/HSD17B7/CRAT/ACAA1/SUCLA2/NBN/YWHAH/ALDH9A1/APEX1/IDH1/GPD2/DLST/HSD17B4/CRYZ/ACAA2/METAP1/UGDH/GABARAPL1/ODC1/ALDOA/ACAT2/ELOVL5/PTS/IDI1/LDHA/ALDH1A1/ACSS1/SUCLG2/HMGCS1/EPHX1/ACSM3/CEL/G0S2/MAOA/HMGCS2/TDO2/FASN/EHHADH/GPD1/BMPR1B/CYP4A22
HALLMARK_G2M_CHECKPOINT HALLMARK_G2M_CHECKPOINT 198 -0.232070674281774 -0.777515453559442 0.985036702428007 1 0.926315789473684 6023 tags=46%, list=37%, signal=30% SS18/RBL1/HSPA8/SLC7A1/EZH2/CHAF1A/TPX2/SRSF10/INCENP/CHMP1A/CHEK1/KATNA1/SMC2/AURKB/TOP2A/ESPL1/RBM14/SRSF2/BUB3/GINS2/KPNA2/POLE/NCL/EWSR1/PDS5B/TROAP/GSPT1/SYNCRIP/KIF20B/MCM5/CDC45/KIF2C/KIF4A/RPA2/RAD21/MCM6/WRN/PML/SMC4/CDC25B/AMD1/TFDP1/CKS1B/KIF23/TMPO/RACGAP1/CDKN3/SLC7A5/CCNB2/KIF22/HUS1/E2F4/NUSAP1/CDKN2C/CDK4/SRSF1/PBK/CDC6/DBF4/MAD2L1/STIL/CDC7/KIF11/HMMR/LMNB1/NOTCH2/BUB1/PRIM2/ODC1/RAD54L/SMC1A/TTK/KNL1/ORC5/SQLE/CDK1/LBR/MCM3/PRMT5/NEK2/CDC20/FBXO5/MYC/EXO1/PLK4/PLK1/MCM2/AURKA/TGFB1/UBE2S/CCNA2/CENPA
HALLMARK_ADIPOGENESIS HALLMARK_ADIPOGENESIS 195 0.206411807836595 0.649398317080807 0.999689778191407 1 0.926315789473684 1158 tags=6%, list=7%, signal=6% LAMA4/MRAP/FABP4/SOWAHC/FZD4/PPARG/MTARC2/LEP/C3/COL15A1/SPARCL1/RETN
HALLMARK_DNA_REPAIR HALLMARK_DNA_REPAIR 147 -0.159197547186767 -0.514986759740879 1 1 0.926315789473684 5605 tags=29%, list=34%, signal=19% POLR1D/GTF3C5/LIG1/GTF2H1/TAF1C/TAF9/AAAS/SURF1/DCTN4/ERCC5/NT5C3A/POLR2A/UMPS/FEN1/TAF10/RPA2/POLR3C/NUDT9/NELFCD/GTF2B/ERCC2/SMAD5/NCBP2/HPRT1/SEC61A1/PRIM1/RAD51/POLR2C/ARL6IP1/POLR2K/POLD1/TAF6/CLP1/SNAPC4/NUDT21/SUPT4H1/BRF2/RFC3/TYMS/SAC3D1/BCAM/CMPK2
HALLMARK_MITOTIC_SPINDLE HALLMARK_MITOTIC_SPINDLE 199 0.187210112266893 0.590263958423629 1 1 0.926315789473684 1312 tags=3%, list=8%, signal=3% SYNPO/SORBS2/CDC42EP2/ARHGAP29/DOCK4/CTTN
HALLMARK_OXIDATIVE_PHOSPHORYLATION HALLMARK_OXIDATIVE_PHOSPHORYLATION 199 -0.186527693164911 -0.625276549830406 1 1 0.926315789473684 5102 tags=30%, list=31%, signal=21% FDX1/HTRA2/VDAC3/PHB2/MTX2/NDUFA7/SDHD/RHOT1/CYC1/HSPA9/VDAC1/LRPPRC/ATP6V1C1/ACADM/SDHA/SDHB/GOT2/RETSAT/ACO2/COX10/PDHB/PRDX3/ATP6V1H/TOMM70/MRPL15/CYB5R3/ACAA1/SUCLA2/MFN2/ALDH6A1/NDUFV2/IDH1/DLST/GLUD1/OGDH/ACAA2/ABCB7/OPA1/MTRR/SLC25A3/BCKDHA/NDUFS1/CYCS/NDUFA5/ACADSB/IDH3A/LDHA/PDP1/ATP5F1B/MRPS22/NNT/PDHX/POR/CASP7/COX11/PDK4/OAT/DLAT/ATP6V0C
HALLMARK_PI3K_AKT_MTOR_SIGNALING HALLMARK_PI3K_AKT_MTOR_SIGNALING 102 0.163339840051756 0.476536517105082 1 1 0.926315789473684 1634 tags=5%, list=10%, signal=4% CDKN1A/IL4/PRKAA2/DDIT3/CAMK4
HALLMARK_UNFOLDED_PROTEIN_RESPONSE HALLMARK_UNFOLDED_PROTEIN_RESPONSE 111 -0.121115811602743 -0.37883599097475 1 1 0.926315789473684 6154 tags=50%, list=37%, signal=31% CXXC1/ATF4/NOLC1/SPCS1/PARN/YIF1A/EIF2AK3/HSPA5/FKBP14/SERP1/ATP6V0D1/HERPUD1/SLC1A4/SLC30A5/MTHFD2/TUBB2A/EEF2/EXOSC9/EIF2S1/NFYA/SPCS3/EXOSC5/NOP14/IARS1/CNOT2/CEBPB/NPM1/EIF4A3/XPOT/SRPRA/HSPA9/EIF4A2/EIF4G1/DNAJA4/PREB/EIF4E/SHC1/CKS1B/SLC7A5/TARS1/HYOU1/PDIA6/CNOT6/PAIP1/DNAJB9/GEMIN4/ALDH18A1/CHAC1/MTREX/CALR/DCTN1/ASNS/XBP1/PSAT1/EDC4
unstrand_96h/GE_ANAK_96h-RNP_NEG_96h-gsea-sasp.txt
0 → 100755
View file @
f9b173e7
ID Description setSize enrichmentScore NES pvalue p.adjust qvalues rank leading_edge core_enrichment
SASP_SCHLEICH SASP_SCHLEICH 71 0.416775449181066 1.15431932484489 0.216881793478261 0.433763586956522 0.433763586956522 2846 tags=39%, list=17%, signal=33% IL13/CSF3/IL6/IGF1/MMP12/CPE/CCL1/KITLG/PLAT/SERPINB2/CXCL13/CCL2/IL1A/SERPINE1/CCL25/CXCR2/IGFBP2/MMP14/TIMP1/AREG/EGF/IGFBP6/CXCL2/VEGFA/GMFG/IGF2R/IGFBP5/ANG
CLASSICAL_SASP CLASSICAL_SASP 33 0.412432940602631 1.00401737223632 0.456952449567723 0.456952449567723 0.456952449567723 2652 tags=48%, list=16%, signal=41% IL13/IL6/BGN/EFEMP1/KITLG/CCL2/MMP9/IL1A/CXCL8/SERPINE1/TNF/IGFBP2/EGF/IGFBP6/VEGFA/THBS1
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