GO_CELLULAR_SENESCENCE	> A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest. [GOC:BHF]	ABL1	AKT3	ARG2	ARNTL	BCL2L12	BCL6	BMPR1A	C2orf40	CALR	CDK6	CDKN1A	CDKN2A	CDKN2B	CGAS	EEF1E1	FBXO5	H2AFX	HLA-G	HMGA1	HMGA2	HRAS	ID2	ING2	KAT6A	KIR2DL4	KRAS	MAGEA2	MAGEA2B	MAP2K1	MAP3K3	MAPK14	MAPKAPK5	MIR10A	MIR146A	MIR17	MIR188	MIR20B	MIR217	MIR22	MIR34A	MIR543	MIR590	NAMPT	NEK4	NEK6	NSMCE2	NUAK1	OPA1	PAWR	PLA2R1	PLK2	PML	PNPT1	PRKCD	PRKDC	PRMT6	RBL1	RSL1D1	SIRT1	SLC30A10	SMC5	SMC6	SRF	TBX2	TBX3	TERC	TERF2	TERT	TP53	TWIST1	ULK3	VASH1	WNT16	YPEL3	ZKSCAN3	ZMPSTE24	ZNF277
GO_STRESS_INDUCED_PREMATURE_SENESCENCE	> A cellular senescence process associated with the dismantling of a cell as a response to environmental factors such as hydrogen peroxide or X-rays. [GOC:BHF]	ARNTL	CDKN1A	MAPK14	MAPKAPK5	PLA2R1	SIRT1	TP53	WNT16
REACTOME_CELLULAR_SENESCENCE	> Cellular Senescence	ACD	AGO1	AGO3	AGO4	AL096870.1	ANAPC1	ANAPC10	ANAPC11	ANAPC15	ANAPC16	ANAPC2	ANAPC4	ANAPC5	ANAPC7	ASF1A	ATM	BMI1	CABIN1	CBX2	CBX4	CBX6	CBX8	CCNA1	CCNA2	CCNE1	CCNE2	CDC16	CDC23	CDC26	CDC27	CDK2	CDK4	CDK6	CDKN1A	CDKN1B	CDKN2A	CDKN2B	CDKN2C	CDKN2D	CEBPB	CXCL8	E2F1	E2F2	E2F3	EED	EHMT1	EHMT2	EP400	ERF	ETS1	ETS2	EZH2	FOS	FZR1	H1F0	H2AFB1	H2AFJ	H2AFV	H2AFX	H2AFZ	H2BFS	H3F3A	H3F3B	HIRA	HIST1H1A	HIST1H1B	HIST1H1C	HIST1H1D	HIST1H1E	HIST1H2AB	HIST1H2AC	HIST1H2AD	HIST1H2AE	HIST1H2AJ	HIST1H2BA	HIST1H2BB	HIST1H2BC	HIST1H2BD	HIST1H2BE	HIST1H2BF	HIST1H2BG	HIST1H2BH	HIST1H2BI	HIST1H2BJ	HIST1H2BK	HIST1H2BL	HIST1H2BM	HIST1H2BN	HIST1H2BO	HIST1H3A	HIST1H3D	HIST1H3E	HIST1H3F	HIST1H3G	HIST1H3H	HIST1H3I	HIST1H3J	HIST1H4A	HIST1H4B	HIST1H4C	HIST1H4D	HIST1H4E	HIST1H4F	HIST1H4H	HIST1H4I	HIST1H4J	HIST1H4K	HIST1H4L	HIST2H2AA3	HIST2H2AA4	HIST2H2AC	HIST2H2BE	HIST2H3A	HIST2H3C	HIST2H3D	HIST2H4A	HIST2H4B	HIST3H2BB	HIST3H3	HIST4H4	HMGA1	HMGA2	ID1	IFNB1	IGFBP7	IL1A	IL6	JUN	KAT5	KDM6B	LMNB1	MAP2K3	MAP2K4	MAP2K6	MAP2K7	MAP3K5	MAP4K4	MAPK1	MAPK10	MAPK11	MAPK14	MAPK3	MAPK7	MAPK8	MAPK9	MAPKAPK2	MAPKAPK3	MAPKAPK5	MDM2	MDM4	MINK1	MIR24-1	MIR24-2	MOV10	MRE11	NBN	NFKB1	PHC1	PHC2	PHC3	POT1	RAD50	RB1	RBBP4	RBBP7	RELA	RING1	RNF2	RPS27A	RPS6KA1	RPS6KA2	RPS6KA3	SCMH1	SP1	STAT3	SUZ12	TERF1	TERF2	TERF2IP	TFDP1	TFDP2	TNIK	TNRC6A	TNRC6B	TNRC6C	TP53	TXN	UBA52	UBB	UBC	UBE2C	UBE2D1	UBE2E1	UBN1
REACTOME_ONCOGENE_INDUCED_SENESCENCE	> Oncogene Induced Senescence	AGO1	AGO3	AGO4	CDK4	CDK6	CDKN2A	CDKN2B	CDKN2C	CDKN2D	E2F1	E2F2	E2F3	ERF	ETS1	ETS2	ID1	MAPK1	MAPK3	MDM2	MDM4	MIR24-1	MIR24-2	MOV10	RB1	RPS27A	SP1	TFDP1	TFDP2	TNRC6A	TNRC6B	TNRC6C	TP53	UBA52	UBB	UBC
REACTOME_OXIDATIVE_STRESS_INDUCED_SENESCENCE	> Oxidative Stress Induced Senescence	AGO1	AGO3	AGO4	BMI1	CBX2	CBX4	CBX6	CBX8	CDK4	CDK6	CDKN2A	CDKN2B	CDKN2C	CDKN2D	E2F1	E2F2	E2F3	EED	EZH2	FOS	H2AFB1	H2AFJ	H2AFV	H2AFX	H2AFZ	H2BFS	H3F3A	H3F3B	HIST1H2AB	HIST1H2AC	HIST1H2AD	HIST1H2AE	HIST1H2AJ	HIST1H2BA	HIST1H2BB	HIST1H2BC	HIST1H2BD	HIST1H2BE	HIST1H2BF	HIST1H2BG	HIST1H2BH	HIST1H2BI	HIST1H2BJ	HIST1H2BK	HIST1H2BL	HIST1H2BM	HIST1H2BN	HIST1H2BO	HIST1H3A	HIST1H3D	HIST1H3E	HIST1H3F	HIST1H3G	HIST1H3H	HIST1H3I	HIST1H3J	HIST1H4A	HIST1H4B	HIST1H4C	HIST1H4D	HIST1H4E	HIST1H4F	HIST1H4H	HIST1H4I	HIST1H4J	HIST1H4K	HIST1H4L	HIST2H2AA3	HIST2H2AA4	HIST2H2AC	HIST2H2BE	HIST2H3A	HIST2H3C	HIST2H3D	HIST2H4A	HIST2H4B	HIST3H2BB	HIST4H4	IFNB1	JUN	KDM6B	MAP2K3	MAP2K4	MAP2K6	MAP2K7	MAP3K5	MAP4K4	MAPK1	MAPK10	MAPK11	MAPK14	MAPK3	MAPK8	MAPK9	MAPKAPK2	MAPKAPK3	MAPKAPK5	MDM2	MDM4	MINK1	MIR24-1	MIR24-2	MOV10	PHC1	PHC2	PHC3	RBBP4	RBBP7	RING1	RNF2	RPS27A	SCMH1	SUZ12	TFDP1	TFDP2	TNIK	TNRC6A	TNRC6B	TNRC6C	TP53	TXN	UBA52	UBB	UBC
GO_CELL_AGING	> An aging process that has as participant a cell after a cell has stopped dividing. Cell aging may occur when a cell has temporarily stopped dividing through cell cycle arrest (GO:0007050) or when a cell has permanently stopped dividing, in which case it is undergoing cellular senescence (GO:0090398). May precede cell death (GO:0008219) and succeed cell maturation (GO:0048469). [GOC:PO_curators]	ABL1	AKT3	ARG2	ARNTL	ATM	ATR	BCL2	BCL2L12	BCL6	BGLAP	BMPR1A	BRCA2	C2orf40	CALR	CDK1	CDK6	CDKN1A	CDKN2A	CDKN2B	CGAS	CHEK1	CHEK2	CTC1	DNAJA3	EEF1E1	ENG	ERCC1	FBXO5	FOXM1	FZR1	H2AFX	HLA-G	HMGA1	HMGA2	HRAS	ICAM1	ID2	ILK	ING2	KAT6A	KIR2DL4	KRAS	LIMS1	LMNA	MAGEA2	MAGEA2B	MAP2K1	MAP3K3	MAPK14	MAPKAPK5	MARCH5	MIF	MIR10A	MIR146A	MIR17	MIR188	MIR20B	MIR21	MIR217	MIR22	MIR34A	MIR543	MIR590	MME	MNT	MORC3	MTOR	NAMPT	NEK4	NEK6	NOX4	NPM1	NSMCE2	NUAK1	NUP62	OPA1	PAWR	PDCD4	PLA2R1	PLK2	PML	PNPT1	PRELP	PRKCD	PRKDC	PRMT6	PTEN	RBL1	ROMO1	RSL1D1	RWDD1	SERPINE1	SIRT1	SLC30A10	SMC5	SMC6	SOD1	SRF	TBX2	TBX3	TERC	TERF2	TERT	TP53	TP63	TWIST1	ULK3	VASH1	WNT1	WNT16	WRN	YPEL3	ZKSCAN3	ZMIZ1	ZMPSTE24	ZNF277
Reactome_Cellular_Senescence	Reactome_Cellular_Senescence	CDKN1A	CDKN2A	CDKN2B	CEBPB	EED	ETS2	EZH2	IGFBP7	IL1A	IL6	IL8	KDM6B	MAP4K4	MINK1	MIR24-1	MIR24-2	SUZ12	TNIK
Reactome_Cellular_responses_to_stress	Reactome_Cellular_responses_to_stress	CA9	CDKN1A	CDKN2A	CDKN2B	CEBPB	COL4A6	CRYBA4	DEDD2	DNAJB1	DNAJB6	EED	EPO	ETS2	EZH2	FKBP4	GML	HIGD1A	HSBP1	HSBP2	HSPA1A	HSPA1B	HSPA1L	HSPA6	HSPH1	IGFBP7	IL1A	IL6	IL8	KDM6B	MAP4K4	MINK1	MIR24-1	MIR24-2	MRPL18	RLN1	SERPINH1	SUZ12	TNFRSF21	TNIK	UBB	VEGFA
Reactome_Oxidative_Stress_Induced_Senescence	Reactome_Oxidative_Stress_Induced_Senescence	CDKN2A	EED	EZH2	KDM6B	MAP4K4	MINK1	MIR24-1	MIR24-2	SUZ12	TNIK
KEGG_SENESCENCE	KEGG_SENESCENCE	AKT1	AKT2	AKT3	ATM	ATR	BTRC	CACNA1D	CALM1	CALM2	CALM3	CALML3	CALML4	CALML5	CALML6	CAPN1	CAPN2	CCNA1	CCNA2	CCNB1	CCNB2	CCNB3	CCND1	CCND2	CCND3	CCNE1	CCNE2	CDC25A	CDK1	CDK2	CDK4	CDK6	CDKN1A	CDKN2CDKN2B	CHEK1	CHEK2	CXCL8	E2F1	E2F2	E2F3	E2F4	E2F5	EIF4EBP1	ETS1	FBXW11	FOXM1	FOXO1	FOXO3	GADD45A	GADD45B	GADD45G	GATA4	HIPK1	HIPK2	HIPK3	HIPK4	HLA-A	HLA-B	HLA-C	HLA-E	HLA-F	HLA-G	HRAS	HUS1	IGFBPIL1A	IL6	ITPR1	ITPR2	ITPR3	KIR2DL1	KIR2DL2	KIR2DL3	KIR2DL4	KIR2DL5A	KRAS	LIN37	LIN52	LIN54	LIN9	MAP2K1	MAP2K2	MAP2K3	MAP2K6	MAPK1	MAPK11	MAPK12	MAPK13	MAPK14	MAPK3	MAPKAPK2	MCU	MDM2	MRAS	MRE11	MTOR	MYBL2	MYC	NBN	NFATC1	NFATC2	NFATC3	NFATC4	NFKB1	NRAS	PIK3CA	PIK3CB	PIK3CD	PIK3R1	PIK3R2	PIK3R3	PPID	PPP1CA	PPP1CB	PPP1CC	PPP3CA	PPP3CB	PPP3CC	PPP3R1	PPP3R2	PTEN	RAD1	RAD50	RAD9A	RAD9B	RAF1	RASSF5	RB1	RBBP4RBL1	RBL2	RELA	RHEB	RRAS	RRAS2	SERPINE1	SIRT1	SLC25A31	SLC25A4	SLC25A5	SLC25A6	SMAD2	SMAD3	SQSTM1	TGFB1	TGFB2	TGFB3	TGFBR1	TGFBR2	TP53	TRAF3IP2	TRPM7	TRPV4	TSC1	TSC2	VDAC1	VDAC2	VDAC3	ZFP36L1	ZFP36L2
Senescence_Demaria	Senescence_Demaria	PLK3	SPATA6	NFIA	TAF13	GSTM4	KCTD3	MEIS1	TMEM87B	GBE1	STAG1	SCOC	ICE1	RAI14	GDNF	P4HA2	PDLIM4	B4GALT7	TSPAN13	ZNHIT1	SMO	CNTLN	CHMP5	FAM214B	USP6NL	TRDMT1	ASCC1	TOLLIP	CCND1	RHNO1	C2CD5	ARID2	DGKA	PDS5B	UFM1	BCL2L2	SUSD6	KLC1	ADPGK	CREBBP	NOL3	ACADVL	EFNB3	SLC16A3	ZBTB7A	DDA1	ARHGAP35	ZC3H4	PCIF1	POFUT2	PATZ1	DYNLT3	SPIN4	PLXNA3	SLC10A3	MT-CYB