This repository includes essential scripts for producing final figures embedded in the following manuscript:
This repository includes all the essential scripts for producing the final main and supplementary figures embedded in the following manuscript:
**Costa Verdera, et al.,** _AAV vectors trigger DNA damage response-dependent pro-inflammatory signalling in human iPSC-derived CNS models and mouse brain_
**Costa Verdera, et al.,** _AAV vectors trigger DNA damage response-dependent pro-inflammatory signalling in human iPSC-derived CNS models and mouse brain_
PubMed: 40251179\
**PubMed:** 40251179\
DOI: 10.1038/s41467-025-58778-3\
**DOI:** 10.1038/s41467-025-58778-3\
GEO: GSE253824
**GEO:** GSE253824
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The repository is divided in five folders, 1 bulk RNAseq analysis, 3 scRNAseq analyses and 1 snRNAseq analysis.
The repository is divided in five folders: _1 bulk RNAseq analysis, 3 scRNAseq analyses and 1 snRNAseq analysis._
Below a brief description of the bulk and scRNAseq workflows adopted in this work.
Below is a brief description of the bulk and scRNAseq workflows adopted in this work:
**Bulk RNAseq** analysis was performed using a standard pipeline that includes the follwing steps:
**Bulk RNAseq** analysis was performed using a standard pipeline that includes the follwing steps:
1. Quality control by [FastQC](https://www.bioinformatics.babraham.ac.uk/projects/fastqc/)
1. Quality control by [FastQC](https://www.bioinformatics.babraham.ac.uk/projects/fastqc/)
